(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

ChemicalBook > CAS DataBase List > (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Product Name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
CAS No.: 915095-86-2
Chemical Name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Synonyms: Englenet Impurity 16;Empagliflozin Impurity 48;2-chloro-4-fluoro-5-Iodobenzophenon;2-Chloro-4'-fluoro-5-iodobenzophenone;2-Chloro-4'-fluoro-5-iodobenzophenone;Empagliflozin Impurity 48 /Englenet Impurity 16;(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon;(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone;Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-
CBNumber: CB12651407
Molecular Formula: C13H7ClFIO
Formula Weight: 360.55
MOL File: 915095-86-2.mol

Less

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Property

Melting point:: 64-70℃
Boiling point:: 415℃
Density: 1.752
Flash point:: 205℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), Ethyl Acetate
form: Solid
color: Off-White
InChI: InChI=1S/C13H7ClFIO/c14-12-6-5-10(16)7-11(12)13(17)8-1-3-9(15)4-2-8/h1-7H
InChIKey: KNYGUQLVFSPVRI-UHFFFAOYSA-N
SMILES: C(C1=CC(I)=CC=C1Cl)(C1=CC=C(F)C=C1)=O

Less

Safety

Safety Statements: 24/25
HS Code: 29142990

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: C368575
Product name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Packaging: 2.5g
Price: $595
Updated: 2021/12/16

AK Scientific

Product number: 9597AF
Product name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Packaging: 100g
Price: $605
Updated: 2021/12/16

Apolloscientific

Product number: PC540099
Product name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Purity: 98%
Packaging: 100g
Price: $634
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 91537
Product name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Packaging: 1g
Price: $725
Updated: 2021/12/16

Apolloscientific

Product number: PC540099
Product name: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone
Purity: 98%
Packaging: 25g
Price: $224
Updated: 2021/12/16

Less

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Chemical Properties,Usage,Production

Uses

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone is a reagent in the synthesis of Empagliflozin (E521510); an inhibitor of SGLT-2.

Synthesis

5-Iodo-2-chlorobenzoic acid (20.0 g, 0.071 mol) was added to a solution of 2.0 M oxalyl chloride in dichloromethane (39 ml, 0.078 mol), stirred for suspension, and then 8 drops of DMF solution was added dropwise. The solution was clarified after the reaction was carried out for 3 hours. The solvent was spin-dried on a rotary evaporator, and then 15 ml of methylene chloride was added. After spin-drying, add 30 ml of dichloromethane, stir, cool to 0-5 ° C, add fluorobenzene (7. lg, 0.074 mol), add anhydrous aluminum trichloride (9.9 g, 0.074 mol) in batches, control The temperature is not more than 5 °C, after the completion of the addition, stirring is continued at 4 ° C for 1 h, the reaction is quenched on the ice-water mixture, the organic phase is separated, and the aqueous phase is extracted with dichloromethane. The phase was washed twice with 1 mol/L hydrochloric acid, once with water, and twice with 1 mol/L NaOH solution. The mixture was washed twice with saturated sodium chloride and dried over anhydrous sodium sulfate. Drain filtration, spin dry solvent to obtain oil after column chromatography, 20. 1g (78.6percent) of a white solid (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone was obtained.

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Suppliers

China 211 India 9 United Kingdom 1 United States 8 Global 229

Carbott PharmTech Inc.

Tel: 0535-6385396
Fax: +86 (535) 638-9971
Email: info@carbottpharm.com
Country: China
ProdList: 917
Advantage: 56

Suzhou Xiaoli Material Technology Co., Ltd.

Tel: 0512-87815088 18015562287
Fax: 0512-69233866
Email: xmwang@xiaolitech.com
Country: China
ProdList: 68
Advantage: 58

Chongqing Ensky Pharmaceutical Co.,Ltd.

Tel: 023-86815286 13983794297
Fax: +86-23-86815116
Email: sales@ensky-chemical.com
Country: China
ProdList: 91
Advantage: 58

HSDK（Nanjing）Pharma Tech Co.，Ltd.

Tel: 15189849794
Email: xiaojin.wu@hsdk-pharmatech.cn
Country: China
ProdList: 25
Advantage: 58

EVERSHINE CHEMICAL CO., LIMITED

Tel: 0571-58120272 17185714011
Email: 3506894070@qq.com
Country: China
ProdList: 85
Advantage: 58

Beijing Stronger Science Co., Ltd.

Tel: 0531-88924771 15614660963
Email: elsa.hang@strongerscience.com
Country: China
ProdList: 10623
Advantage: 58

Beijing Huikang Boyuan Chemical Tech Co., Ltd

Tel: 010-68862197 13810598707
Fax: 010-68882204
Email: sales@huikangchem.com
Country: China
ProdList: 103
Advantage: 61

Beijing HwrkChemical Technology Co., Ltd

Tel: 010-89508211 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 8418
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Suzhou Zehou Biotechnology Co. , Ltd.

Tel: 0512-68716880 19984816880
Fax: 18075373931
Email: sales@growingchem.com
Country: China
ProdList: 192
Advantage: 64

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14103
Advantage: 59

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42958
Advantage: 64

China Langchem Inc.

Tel: 021-58956006 15800617331
Fax: 021-58956100
Email: sales4@langchem.com
Country: China
ProdList: 206
Advantage: 57

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 4554
Advantage: 62

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-4000505016 13380397412
Fax: 0755 28094224
Email: 3001272453@qq.com
Country: China
ProdList: 5047
Advantage: 50

Tianjin Branch Chong pharmaceutical intermediates Co., Ltd.

Tel: 022-60116533 13207668525
Fax: 022-60979672
Email: saleskc@scipharmacn.com
Country: China
ProdList: 683
Advantage: 58

Shanghai T&W Pharmaceutical Co., Ltd.

Tel: +86 21 61551611
Fax: +86 21 50676805
Country: China
ProdList: 9891
Advantage: 58

Emei shan Hongsheng Pharmaceutical Co., LTD

Tel: 0833-6186278 19162541913;
Fax: 0833-5590359
Email: sales@hongshengpharm.com
Country: China
ProdList: 109
Advantage: 60

HuBei ShengBaoLai Biological Technology Co., Ltd

Tel: 027-59105235 13007105135
Fax: 027-59105235
Email: sbl1120@163.com
Country: China
ProdList: 107
Advantage: 55

Taizhou Tongxin Bio-Tech Co., Ltd

Tel: 0523-18601685-898 18652728585
Email: sales@allyrise.com
Country: China
ProdList: 2778
Advantage: 60

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41462
Advantage: 60

Chongqing Carechem Co.,Ltd.

Tel: 18680818008/15802381793
Fax: 086-23-86109835
Email: cqudgh@126.com
Country: China
ProdList: 57
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18070
Advantage: 56

Hydragon Pharma Ltd

Tel: 021-50215258
Fax: 021-50215756
Email: market@hypharma.com
Country: China
ProdList: 321
Advantage: 58

Shanghai Kewel Chemical Co., Ltd.

Tel: 021-64609169 18901607656
Fax: 021-64609160
Email: greensnown@163.com
Country: China
ProdList: 9906
Advantage: 50

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Gansu HaoTian Chemical Technology Co., Ltd.

Tel: 0943-6900332 17789447501
Fax: 0931-8238232
Email: zhuanxiajiang@haotianpharm.com
Country: China
ProdList: 194
Advantage: 55

Watson Biotechnology Co.,Ltd

Tel: 027-59207879 1972026995 18140587686
Fax: QQ：1972026995
Email: sales@3600chem.com
Country: China
ProdList: 4661
Advantage: 55

Nanjing XiZe Biotechnology CO., Ltd.

Tel: 025-66023220 0086-15250997978
Fax: 025-58362220
Email: 1511893459@qq.com
Country: China
ProdList: 7850
Advantage: 55

Intelligence Pharm Science(Shanghai) Co., Ltd.

Tel: 021-57898186
Fax: 021-37699262
Country: China
ProdList: 449
Advantage: 55

Anqing CHICO Pharmaceutical Co., Ltd.

Tel: 13585175604
Fax: +86-25-52261140
Email: sales@chicopharm.com
Country: China
ProdList: 444
Advantage: 65

Nanjing Chempioneer Pharmaceutical Co., Ltd.

Tel: 18068075658
Fax: -
Email: sales@chempioneer.com
Country: China
ProdList: 1811
Advantage: 58

Zhengzhou Alfachem Co., Ltd.

Tel: 0371-53765687 18937137882
Fax: QQ:2885373884
Email: 2853979813@qq.com
Country: China
ProdList: 7977
Advantage: 55

Shanghai Rochi Pharmaceutical Co., Ltd.

Tel: 021-38751876 15000076078
Fax: 021-50275764
Email: Info@rochipharma.com
Country: China
ProdList: 568
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27313
Advantage: 60

BePharm Ltd

Tel: 400-685-9117
Fax: 021-51816740
Email: market@bepharm.com
Country: China
ProdList: 15081
Advantage: 60

Cangzhou Enke Pharma-tech Co., Ltd.

Tel: 0317-5296180 15533709196
Fax: 0317-5106596
Email: sale@enkepharma.com
Country: China
ProdList: 1896
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 6270
Advantage: 58

Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
Fax: 037155629727
Email: 2885676761@qq.com
Country: China
ProdList: 9995
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29785
Advantage: 68

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Nanjing KaiMubo Pharmaceutical Co., Ltd.

Tel: 025-66162170
Fax: 025-66162170
Country: China
ProdList: 7181
Advantage: 55

Henan Anky Chemical Technology Co., Ltd.

Tel: 17836913271
Fax: 0374-8348899
Email: 3224305243@qq.com
Country: China
ProdList: 2920
Advantage: 58

Porton Pharma Solutions Ltd.

Tel: 23-86083200-6540
Fax: 023860832006830
Email: jia.chen@portonpharma.com
Country: China
ProdList: 56
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718 +86-13336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29791
Advantage: 60

Aikon International Limited

Tel: 025-66113011 18112977050
Fax: (5)02557626880
Email: cb6@aikonchem.com
Country: China
ProdList: 15494
Advantage: 58

Conier Chem & Pharma Limited

Tel: 13368167990
Email: sales@conier.com
Country: China
ProdList: 2833
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17987
Advantage: 58

Less

View Lastest Price from (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone manufacturers

Suzhou Nordica Biopharma CO.,LTD

Product: 2-Chloro-4'-fluoro-5-iodobenzophenone 915095-86-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 5 tons
Release date: 2024-11-14

Hebei Yanxi Chemical Co., Ltd.

Product: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

Shanghai Joiny Pharmaceutical Co.,LTD

Product: (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone 915095-86-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 500k
Release date: 2023-09-08

915095-86-2, (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanoneRelated Search:

Acetoxy Empagliflozin Empagliflozin Impurity 23 Empagliflozin (R)-Isomer ((2R,3S,4R,5R,6S)-6-(4-chloro-3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)phenyl)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)Methyl acetate N/A Butanoic acid, 4-chloro-3-hydroxy-, (3S)- (4R,5R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl) phenyl)-5-((R)-1,2-dihydroxyethyl)tetrahydrofuran-3,4-diol (3R,4S,5S,6R)-2-(4-chloro-3-(4-(((S)-tetrahydrofuran-3-yl)oxy)benzyl)phenyl)-6-(hydroxyMethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol 4-CHLORO-2-FLUOROIODOBENZENE DIPHENYLENEIODONIUM CHLORIDE (S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone

Methanone, (2-chloro-5-iodophenyl)(4-fluorophenyl)-

(2-Chloro-5-iodobenyl)(4-fluorophenyl)methanone

Empagliflozin Impurity 48

Englenet Impurity 16

2-chloro-4-fluoro-5-Iodobenzophenon

(2-Chloro-5-iodophenyl)(4-fluorophenyl)methanon

2-Chloro-4'-fluoro-5-iodobenzophenone

(2-Chloro-5-iodine phenyl) 4-fluorophenyl) methylone

Empagliflozin Impurity 48 /Englenet Impurity 16

2-Chloro-4'-fluoro-5-iodobenzophenone

915095-86-2

945065-86-2

C13H7ClFIO