Inauhzin

Product Name: Inauhzin
CAS No.: 309271-94-1
Chemical Name: Inauhzin
Synonyms: INZ;CS-1439;Inauhzin;Chlormax;Inauhzin(INZ);Inauhzin, >=98%;10-[1-Oxo-2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)butyl]-10H-phenothiazine;"1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one";2-(9H-[1,2,4]TRIAZINO[6,5-B]INDOL-3-YLTHIO)-1-(10H-PHENOTHIAZIN-10-YL)BUTAN-1-ONE;1-Butanone, 1-(10H-phenothiazin-10-yl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)-
CBNumber: CB62681971
Molecular Formula: C25H19N5OS2
Formula Weight: 469.58
MOL File: 309271-94-1.mol

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Inauhzin Property

Boiling point:: 773.6±70.0 °C(Predicted)
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥23.5 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
pka: 10.24±0.50(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19771
Product name: Inauhzin
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 19771
Product name: Inauhzin
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 19771
Product name: Inauhzin
Purity: ≥98%
Packaging: 10mg
Price: $184
Updated: 2024/03/01

TRC

Product number: P318090
Product name: 1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one(Inauhzin)
Packaging: 5mg
Price: $50
Updated: 2021/12/16

ApexBio Technology

Product number: B3272
Product name: Inauhzin
Packaging: 10mM(in 1mL DMSO)
Price: $110
Updated: 2021/12/16

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Inauhzin Chemical Properties,Usage,Production

Uses

Inauhzin acts as an inhibitor of SIRT1 activity, and also activates p53 resulting in a decrease in tumor growth.

Biological Activity

inauhzin is a small-molecule inhibitor of sirt1 with ic50 value of 0.7-2μm [1].inauhzin inhibits sirt1 deacetylation activity and subsequently activates the substrate of sirt1, p53, in a dose-dependent manner. it shows an induction of acetylation of p53 and histone h3 in the k382 and k9 residues, respectively. the inhibition of sirt1 is selective. it has no significant effect on sirt2, sirt3 or hdac8 in the fluor-de-lys fluorimetric assay. since it is an activator of p53, inauhzin inhibits cell growth in different p53-containing human cancer cells including h460, h1299, a549, ht29 and wi38. the ic50 values are 5.4μm, 51.9μm, 3.2μm, 33.9μm and 85.4μm, respectively. furthermore, inauhzin induces cell apoptosis through activating p53. in the xenograft tumours derived from h460 cells, inauhzin also significantly induces p53 activity and p53-dependent apoptosis at 2μm [1].

References

[1] zhang q, zeng sx, zhang y, zhang y, ding d, ye q, meroueh so, lu h. a small molecule inauhzin inhibits sirt1 activity and suppresses tumour growth through activation of p53. embo mol med. 2012 apr;4(4):298-312.

Inauhzin Preparation Products And Raw materials

Raw materials

Preparation Products

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Inauhzin Suppliers

Canada 1 China 78 India 2 United Kingdom 1 United States 13 Global 95

AdooQ BioScience, LLC

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Target molecule Corp.

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Musechem

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Email: info@musechem.com
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
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InvivoChem

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Cckinase, Inc.

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Aladdin Scientific

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ApexBio Technology

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Cayman Chemical Company

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MedChemExpress

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Combi-Blocks Inc.

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Matrix Scientific

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NE Scientific

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309271-94-1, InauhzinRelated Search:

Inauhzin, >=98%

2-((5H-[1,2,4]Triazino[5,6-b]indol-3-yl)thio)-1-(10H-phenothiazin-10-yl)butan-1-one

Inauhzin

1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one (Inauhzin)

2-(9H-[1,2,4]TRIAZINO[6,5-B]INDOL-3-YLTHIO)-1-(10H-PHENOTHIAZIN-10-YL)BUTAN-1-ONE

10-[1-Oxo-2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)butyl]-10H-phenothiazine

Inauhzin(INZ)

10-[1-Oxo-2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)butyl]-10H-phenothiazine Inauhzin(INZ)

Inauhzin 10-[1-Oxo-2-(2H-1,2,4-triazino[5,6-b]indol-3-ylthio)butyl]-10H-phenothiazine

<br>1-(10H-phenothiazin-10-yl)-2-(5H-[1,2,4]triazino[5,6-b]indol-3-ylsulfanyl)b utan-1-one

INZ

CS-1439

1-Butanone, 1-(10H-phenothiazin-10-yl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)-

Inauhzin 1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2- ylsulfanyl)-butan-1-one

"1-Phenothiazin-10-yl-2-(9H-1,3,4,9-tetraaza-fluoren-2-ylsufanyl)-butan-1-one"

Chlormax

309271-94-1

Inhibitors