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ABT-333

Product Name
ABT-333
CAS No.
1132935-63-7
Chemical Name
ABT-333
Synonyms
CS-2000;ABT-333;Dasabuvir;ABT333; ABT 333;ABT-333/Dasabuvir;Dasabuvir (ABT-333);Dasabuvir-13C 15N2 D3;N-{6-[5-(2,4-Dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-methoxy-3-(2-methyl-2-propanyl)phenyl]-2-naphthyl}methanesulfonamide;Methanesulfonamide, N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-;N-[6-[3-tert-Butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Dasabuvir (ABT-333)
CBNumber
CB62681991
Molecular Formula
C26H27N3O5S
Formula Weight
493.57
MOL File
1132935-63-7.mol
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ABT-333 Property

Melting point:
>192oC (dec.)
Density 
1.317±0.06 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly, Heated), DMSO (Slightly), Methanol (Slightly, Heated)
pka
8.52±0.30(Predicted)
form 
Solid
color 
Pale Brown to Light Brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18482
Product name
ABT-333
Purity
≥98%
Packaging
5mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18482
Product name
ABT-333
Purity
≥98%
Packaging
10mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
18482
Product name
ABT-333
Purity
≥98%
Packaging
25mg
Price
$172
Updated
2024/03/01
Cayman Chemical
Product number
18482
Product name
ABT-333
Purity
≥98%
Packaging
50mg
Price
$235
Updated
2024/03/01
TRC
Product number
D193550
Product name
Dasabuvir
Packaging
1mg
Price
$50
Updated
2021/12/16
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ABT-333 Chemical Properties,Usage,Production

Uses

Dasabuvir is an antiviral drug used in the treatment of chronic hepatitis C virus (HCV) infection.

Definition

ChEBI: A member of the class of pyrimidone, which is (as the monohydrate of its sodium salt) in combination with ombitasvir, paritaprevir and ritonavir (under the trade name Viekira Pak) for treatment of chronic hepatitis C virus genotype 1 infection as well as c rrhosis of the liver.

Clinical Use

Treatment of chronic hepatitis C infection

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: avoid concomitant use with clarithromycin and telithromycin; concentration possibly reduced by rifampicin - avoid.
Antidepressants: concentration possibly reduced by St John’s wort - avoid.
Antiepileptics: concentration reduced by carbamazepine - avoid; concentration possibly reduced by fosphenytoin, phenobarbital, phenytoin and primidone - avoid.
Antifungals: concentration of both drugs increased with ketoconazole and possibly itraconazole and posaconazole - avoid.
Diuretics: concentration of furosemide increased (reduce furosemide dose).
Immunosuppressants: increases concentration of ciclosporin (reduce ciclosporin dose by a fifth); everolimus (avoid); sirolimus and tacrolimus (reduce dose and use only if benefit outweighs risk - see SPC).
Lipid-regulating drugs: avoid with atorvastatin, gemfibrozil and simvastatin; concentration of rosuvastatin increased (reduce dose of rosuvastatin).
Oestrogens: avoid concomitant use with ethinylestradiol.

Metabolism

Dasabuvir is mainly metabolised by CYP2C8 and to a lesser extent by CYP3A. Seven metabolites were identified in plasma. The most abundant plasma metabolite was M1, which represented 21% of drugrelated radioactivity (AUC) in circulation following single dose; it is formed via oxidative metabolism predominantly by CYP2C8.
Following a 400 mg 14C-dasabuvir dose, approximately 94% of the radioactivity was recovered in faeces with limited radioactivity (approximately 2%) in urine. Unchanged dasabuvir accounted for 26.2% and M1 for 31.5% of the total dose in faeces. M1 is mainly cleared through direct biliary excretion with the contribution of UGT-mediated glucuronidation and, to a small extent, oxidative metabolism.

ABT-333 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABT-333 Suppliers

BSAZ Biotech Co.,Ltd.
Tel
0571-28111272 18505711187
Fax
0571 56260350
Email
peter@bsaz.com
Country
China
ProdList
36
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
ChemCell Biomedicine Co.,Ltd.
Tel
020-13556033878 2965585218 13556033878
Fax
0086-0757-85406358
Email
chemcell@hotmail.com
Country
China
ProdList
369
Advantage
52
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
meilunui@163.com
Country
China
ProdList
4727
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
Country
China
ProdList
7295
Advantage
60
Shanghai AQBioPharma Co., Ltd.
Tel
13764862135
Fax
51370935-8011
Email
yaoliang.ni@aqbiopharma.com.cn
Country
China
ProdList
2759
Advantage
58
Shanghai Synteam Biochem CO.,ltd
Tel
+86-021-58380978 +86-18017016373
Fax
021-58380978
Email
info@systeambc.com
Country
China
ProdList
942
Advantage
50
Shanghai Tombiopharma Chemical Co. Ltd.
Tel
13391076197
Email
tombiopharma@163.com
Country
China
ProdList
4987
Advantage
55
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View Lastest Price from ABT-333 manufacturers

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Dasabuvir 1132935-63-7
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-09-04
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Abt333 1132935-63-7
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-10-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
dasabuvir 1132935-63-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

1132935-63-7, ABT-333Related Search:


  • ABT-333
  • Dasabuvir (ABT-333)
  • N-[6-[3-tert-Butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl]naphthalen-2-yl]methanesulfonamide Dasabuvir (ABT-333)
  • Dasabuvir
  • ABT-333/Dasabuvir
  • N-{6-[5-(2,4-Dioxo-3,4-dihydro-1(2H)-pyrimidinyl)-2-methoxy-3-(2-methyl-2-propanyl)phenyl]-2-naphthyl}methanesulfonamide
  • CS-2000
  • ABT333; ABT 333
  • Methanesulfonamide, N-[6-[5-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-3-(1,1-dimethylethyl)-2-methoxyphenyl]-2-naphthalenyl]-
  • Dasabuvir-13C 15N2 D3
  • 1132935-63-7
  • 132935-63-7