PF 06465469 Discontinued See A191400

Product Name: PF 06465469 Discontinued See A191400
CAS No.: 1407966-77-1
Chemical Name: PF 06465469 Discontinued See A191400
Synonyms: PF 06465469;PF06465469,PF 06465469;PF 06465469 Discontinued See A191400;(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropyl-3-methylphenyl)benzamide;3-[4-amino-1-[(3R)-1-prop-2-enoyl-3-piperidyl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-3-methyl-phenyl)benzamide;(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-aMino-1H-pyrazolo[3,4-d]pyriMidin-3-yl]-N-(4-isopropyl-5-Methylphenyl)benzaMide;(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide;3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide;Benzamide, 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-
CBNumber: CB62694359
Molecular Formula: C30H33N7O2
Formula Weight: 523.63
MOL File: 1407966-77-1.mol

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PF 06465469 Discontinued See A191400 Property

Melting point:: 209-212°C
Boiling point:: 730.2±60.0 °C(Predicted)
Density: 1.30±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear
pka: 12.83±0.70(Predicted)
form: powder
color: white to beige

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0209
Product name: PF-06465469
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $128
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0209
Product name: PF-06465469
Purity: ≥97% (HPLC)
Packaging: 25mg
Price: $496
Updated: 2024/03/01

Tocris

Product number: 4710
Product name: PF06465469
Purity: ≥95%(HPLC)
Packaging: 10
Price: $300
Updated: 2021/12/16

Tocris

Product number: 4710
Product name: PF06465469
Purity: ≥95%(HPLC)
Packaging: 50
Price: $1208
Updated: 2021/12/16

TRC

Product number: A191400
Product name: (R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-5-methylphenyl)benzamide
Packaging: 2.5mg
Price: $385
Updated: 2021/12/16

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PF 06465469 Discontinued See A191400 Chemical Properties,Usage,Production

Chemical Properties

Beige Solid

Uses

PF 06465469 is a covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with nanomolar potency in a whole-blood assay.

Uses

(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-5-methylphenyl)benzamide is a potential covalent inhibitor of Interleukin-2 Inducible T Cell KInase (Itk). Itk is a member of the TEC-kinase family and is associated with the induction of T cell proliferation and drives cytokines through NFATc.

storage

Store at +4°C

PF 06465469 Discontinued See A191400 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 06465469 Discontinued See A191400 Suppliers

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1407966-77-1, PF 06465469 Discontinued See A191400Related Search:

PF 06465469 Discontinued See A191400

(R)-3-[1-(1-Acryloylpiperidin-3-yl)-4-aMino-1H-pyrazolo[3,4-d]pyriMidin-3-yl]-N-(4-isopropyl-5-Methylphenyl)benzaMide

PF 06465469

3-[4-Amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-benzamide

(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(3-methyl-4-(1-methylethyl))benzamide

Benzamide, 3-[4-amino-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-N-[3-methyl-4-(1-methylethyl)phenyl]-

PF06465469,PF 06465469

3-[4-amino-1-[(3R)-1-prop-2-enoyl-3-piperidyl]pyrazolo[3,4-d]pyrimidin-3-yl]-N-(4-isopropyl-3-methyl-phenyl)benzamide

(R)-3-(1-(1-Acryloylpiperidin-3-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4-isopropyl-3-methylphenyl)benzamide

1407966-77-1

Aromatics, Heterocycles, Inhibitors, Pfizer Compounds, Pharmaceuticals, Intermediates & Fine Chemicals

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals