(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile
- Product Name
- (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile
- CAS No.
- 727382-14-1
- Chemical Name
- (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile
- Synonyms
- 2,4-Dichlorobenzyl Alcohol Impurity 38;(3S) -4-chloro-3- [(trimethylsilyl) oxy] nitrile;(S)-4-chloro-3-((trimethylsilyl)oxy)butanenitrile;(S)-4-Chloro-3-(trimethylsilanyloxy)butyronitrile;(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile;Butanenitrile, 4-chloro-3-[(trimethylsilyl)oxy]-, (3S)-
- CBNumber
- CB62694490
- Molecular Formula
- C7H14ClNOSi
- Formula Weight
- 191.73
- MOL File
- 727382-14-1.mol
(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile Property
- Boiling point:
- 233.8±20.0 °C(Predicted)
- Density
- 1.002±0.06 g/cm3(Predicted)
- form
- liquid
- color
- light yellow
- InChI
- InChI=1S/C7H14ClNOSi/c1-11(2,3)10-7(6-8)4-5-9/h7H,4,6H2,1-3H3/t7-/m0/s1
- InChIKey
- FLYSOKSACGLOAO-ZETCQYMHSA-N
- SMILES
- C(#N)C[C@H](O[Si](C)(C)C)CCl
N-Bromosuccinimide Price
- Product number
- C432720
- Product name
- (3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanenitrile
- Packaging
- 50mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- C432720
- Product name
- (3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanenitrile
- Packaging
- 500mg
- Price
- $1320
- Updated
- 2021/12/16
(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile Chemical Properties,Usage,Production
Description
(3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanenitrile, also known as (3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanenitrile, is a useful research compound. Its molecular formula is C7H14ClNOSi and its molecular weight is 191.73 g/mol. The purity is usually 95%.
Uses
(3S)-4-Chloro-3-[(trimethylsilyl)oxy]butanenitrile is used in the synthesis of statins or HMG-CoA reductase inhibitors.
Synthesis
The synthesis of (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile is as follows:
To a solution of (S)-4-chloro-3-hydroxy butanenitrile (52.5 g) in THF (150 mL) was added trimethyl silyl chloride (57.2 g) under inert atmosphere at 25 °C. The resulting reaction mixture was stirred for 10 min at 20°C. A solution of triethyl amine (53.4 g) in THF (100 mL) was added to above reaction mixture by maintaining reaction temperature below 40 °C. To the resulting reaction mixture catalytic amount of sodium iodide was added and stirred further for 5 h at 40°C. Reaction was monitored on GC as well TLC for complete conversion of starting material. After cooling to 0 °C, a 21% aqueous solution of sodium chloride (500 mL) was added and extracted with ethyl acetate (2 X 300 mL). Combined organic layer was dried with anhydrous sodium sulphate, filtered and concentrated under reduced pressure to obtain (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile as light brown liquid (84.0 g, 99%).
(3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile manufacturers
- Product
- (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile 727382-14-1
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-09-08
- Product
- (3S)-4-Chloro-3-[(triMethylsilyl)oxy]butanenitrile 727382-14-1
- Price
- US $10.00/KG
- Min. Order
- 100KG
- Purity
- 99%
- Supply Ability
- 100
- Release date
- 2020-12-11