ChemicalBook > CAS DataBase List > 3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester

3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester

Product Name
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester
CAS No.
890190-22-4
Chemical Name
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester
Synonyms
WDR5-0103;WDR50103, >98%;WDR5(WDR5-0103);WD-Repeat Protein 5-0103;WDR5-0103, 10 mM in DMSO;WD-REPEAT PROTEIN 5-0103;WDR5 0103;WDR50103;Methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate;3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester;Benzoic acid, 3-[(3-methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)-, methyl ester
CBNumber
CB62695169
Molecular Formula
C21H25N3O4
Formula Weight
383.44
MOL File
890190-22-4.mol
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3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Property

Boiling point:
495.2±45.0 °C(Predicted)
Density 
1.223±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: soluble10mg/mL, clear
form 
powder
pka
12.96±0.70(Predicted)
color 
white to beige
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
13945
Product name
WDR5-0103
Purity
≥95%
Packaging
1mg
Price
$28
Updated
2026/04/30
Cayman Chemical
Product number
13945
Product name
WDR5-0103
Purity
≥95%
Packaging
5mg
Price
$90
Updated
2026/04/30
Cayman Chemical
Product number
13945
Product name
WDR5-0103
Purity
≥95%
Packaging
10mg
Price
$165
Updated
2026/04/30
Cayman Chemical
Product number
13945
Product name
WDR5-0103
Purity
≥95%
Packaging
25mg
Price
$345
Updated
2026/04/30
Cayman Chemical
Product number
13945
Product name
WDR5-0103
Purity
≥95%
Packaging
1mg
Price
$62
Updated
2024/03/01
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3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Chemical Properties,Usage,Production

Description

WD-repeat protein 5 (WDR5) is a scaffold protein commonly involved in the formation of nucleosome-modifying protein complexes with histones. For example, WDR5 is a component of a mixed-lineage leukemia (MLL) methyltransferase complex that targets histone 3. WDR5 can also be a component of histone acetyltransferase complexes and can directly bind methylated as well as unmodified histones. WDR5-0103 is a small molecule that binds a peptide-binding pocket on WDR5 (Kd = 450 nM), inhibiting the catalytic activity of the MLL core complex in vitro (IC50 = 39 μM).

Uses

3-[(3-Methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)benzoic Acid Methyl Ester is an small molecule inhibitor of WDR5, an essential componet of the human trithorax-like famliy of SET1 methyltransferase complexes that carry out trimethylation of histone 3 Lys4.

in vivo

WDR5-0103 (2.5 mg/kg; intraperitoneal injection; once a day; for 3 days) can reduce the level of H3K4me3, improve cognitive deficits and restore synaptic function in P301S transgenic Tau mice[3].
WDR5-0103 (2.5 mg/kg; intraperitoneal injection; three times) can reduce the level of H3K4me3 in the prefrontal cortex and improve cognitive function in 5xFAD mice[3].

Animal Model:P301S transgenic Tau mice (both male and female, 5-6 months old)[3]
Dosage:2.5 mg/kg (dissolved in DMSO and diluted with saline, DMSO concentration of working solution < 0.2%)
Administration:Intraperitoneal injection, once a day, for 3 days
Result:In behavioral tests, the discrimination ratio in the novel object recognition test and the spatial memory index in the Barnes maze test were significantly improved, indicating the amelioration of cognitive deficits.
Western blot analysis showed that the decreased levels of synaptic GluR1, NR1, and NR2A subunits were remarkably restored.
Animal Model:5xFAD mice (both male and female, 5-6 months old; transgenic mice carrying five familial AD mutations on human amyloid precursor protein and human presenilin 1, a model of Alzheimer's disease)[3]
Dosage:2.5 mg/kg (dissolved in DMSO and diluted with saline, DMSO concentration of working solution < 0.2%)
Administration:Intraperitoneal injection, three times
Result:Reduced the level of H3K4me3 in the prefrontal cortex of 5xFAD mice. In behavioral tests, the discrimination ratio in the novel object recognition test and the spatial memory index in the Barnes maze test were significantly improved, indicating the improvement of cognitive function.

storage

Store at +4°C

References

[1] VALENTINA MIGLIORI  Ernesto G  Marina Mapelli. On WD40 proteins: propelling our knowledge of transcriptional control[J]. Epigenetics, 2012, 7 8: 815-822. DOI: 10.4161/epi.21140
[2] ERNESTO GUCCIONE. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive[J]. Nature, 2007, 449 7164: 933-937. DOI: 10.1038/nature06166
[3] SEBASTIáN GUELMAN. The double-histone-acetyltransferase complex ATAC is essential for mammalian development.[J]. Molecular and Cellular Biology, 2009, 29 5: 1176-1188. DOI: 10.1128/mcb.01599-08
[4] GUILLERMO SENISTERRA. Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.[J]. Biochemical Journal, 2013, 449 1: 151-159. DOI: 10.1042/bj20121280
[5] TIM J WIGLE  Robert A C. Drugging the human methylome: an emerging modality for reversible control of aberrant gene transcription[J]. Current Opinion in Chemical Biology, 2013, 17 3: Pages 369-378. DOI: 10.1016/j.cbpa.2013.03.035

3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester Suppliers

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View Lastest Price from 3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester manufacturers

Career Henan Chemical Co
Product
3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester 890190-22-4
Price
US $0.10/g
Min. Order
1g
Purity
98%min
Supply Ability
10g,100g
Release date
2020-01-09

890190-22-4, 3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl EsterRelated Search:


  • 3-[(3-Methoxybenzoyl)aMino]-4-(4-Methyl-1-piperazinyl)benzoic Acid Methyl Ester
  • Methyl 3-(3-methoxybenzamido)-4-(4-methylpiperazin-1-yl)benzoate
  • WDR5-0103
  • WDR50103, >98%
  • WD-Repeat Protein 5-0103
  • WD-REPEAT PROTEIN 5-0103;WDR5 0103;WDR50103
  • Benzoic acid, 3-[(3-methoxybenzoyl)amino]-4-(4-methyl-1-piperazinyl)-, methyl ester
  • WDR5(WDR5-0103)
  • WDR5-0103, 10 mM in DMSO
  • 890190-22-4
  • Amines, Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals