ChemicalBook > CAS DataBase List > 8-OXO-2'-DEOXYGUANOSINE

8-OXO-2'-DEOXYGUANOSINE

Product Name
8-OXO-2'-DEOXYGUANOSINE
CAS No.
88847-89-6
Chemical Name
8-OXO-2'-DEOXYGUANOSINE
Synonyms
8-hydroxydeoxyguanosine;8-Hydroxy-dG;-deoxyguanosine;8-Hydroxy-2'-dG;8-Oxodeoxyguanosine;2-Amino-9-((2R,4S,5R);-3H-purine-6,8(7H,9H);2'-Deoxy-8-oxoguanosine;8-oxo-2'-deoxyGuanosine;2’-Deoxy-8-oxoguanosine
CBNumber
CB6269667
Molecular Formula
C10H13N5O5
Formula Weight
283.24
MOL File
88847-89-6.mol
More
Less

8-OXO-2'-DEOXYGUANOSINE Property

Melting point:
217-220°C
Density 
2.25±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 10 mg/ml).
form 
White to off-white solid.
pka
7.86±0.20(Predicted)
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChI
InChI=1S/C10H13N5O5/c11-9-13-7-6(8(18)14-9)12-10(19)15(7)5-1-3(17)4(2-16)20-5/h3-5,16-17H,1-2H2,(H,12,19)(H3,11,13,14,18)/t3-,4+,5+/m0/s1
InChIKey
HCAJQHYUCKICQH-VPENINKCSA-N
SMILES
OC[C@H]1O[C@@H](N2C3=C(C(NC(=N3)N)=O)NC2=O)C[C@@H]1O
More
Less

Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
MF8782675
HS Code 
29349990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H5653
Product name
8-Hydroxy-2′-deoxyguanosine
Purity
≥98% (TLC)
Packaging
1mg
Price
$97.7
Updated
2025/07/31
Sigma-Aldrich
Product number
H5653
Product name
8-Hydroxy-2′-deoxyguanosine
Purity
≥98% (TLC)
Packaging
5mg
Price
$321
Updated
2025/07/31
Cayman Chemical
Product number
89320
Product name
8-Hydroxy-2'-deoxyguanosine
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
89320
Product name
8-Hydroxy-2'-deoxyguanosine
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
89320
Product name
8-Hydroxy-2'-deoxyguanosine
Purity
≥98%
Packaging
10mg
Price
$363
Updated
2024/03/01
More
Less

8-OXO-2'-DEOXYGUANOSINE Chemical Properties,Usage,Production

Description

8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1?It is a critical biomarker for oxidative stress and carcinogenesis.2,3

Chemical Properties

White Crystalline Solid

Uses

A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.

Uses

8-Hydroxy-2′-deoxyguanosine has been used:

  • as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
  • as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
  • as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential?antioxidant?activity of green coffee bean extract (GCBE) in vivo
  • as a standard for LC/MS/MS analysis

Definition

ChEBI: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.

Biochem/physiol Actions

A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis

References

[1] K B BECKMAN  B N A. Oxidative decay of DNA.[J]. The Journal of Biological Chemistry, 1997, 272 32: 19633-19636. DOI:10.1074/jbc.272.32.19633
[2] ROBERTA ANDREOLI. Quantitative determination of urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile in healthy volunteers.[J]. Biomarkers, 2010, 15 3: 221-231. DOI:10.3109/13547500903434501
[3] PAOLA MANINI . Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers[J]. Toxicology letters, 2009, 190 1: Pages 41-47. DOI:10.1016/j.toxlet.2009.06.862

8-OXO-2'-DEOXYGUANOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

8-OXO-2'-DEOXYGUANOSINE Suppliers

Canada 1 China 117 Germany 3 India 3 Switzerland 3 United Kingdom 4 United States 20 Global 151
Beijing Boorsen Biotechnology Co., Ltd
Tel
400-901-9800 18611424007
Email
cis@bioss.com.cn
Country
China
ProdList
9518
Advantage
58
Shanghai Kaisen Biotechnology Co., Ltd
Tel
17558870519
Email
3549952815@qq.com
Country
China
ProdList
2312
Advantage
58
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Wuhu Huaren Science and Technology Co., Ltd.
Tel
0553-5842013-801 18155347026
Fax
086-553-5843138
Email
jinhuaren@huarensh.com
Country
China
ProdList
255
Advantage
64
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4999
Advantage
60
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-6206333 13167063860
Fax
021-50323701
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
TianJin Alta Scientific Co., Ltd.
Tel
022-65378550-8551
Fax
+86-022-2532-9655
Email
contact@altascientific.com
Country
China
ProdList
2773
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
NINGBO INNO PHARMCHEM CO.,LTD.
Tel
86-574-27787657
Fax
86-574-27912196
Email
info@dearchem.com
Country
China
ProdList
4613
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Changzhou PBpharmaceutical R&D Co.,Ltd
Tel
086-0519-83990708 18915800124
Fax
0519-83990708
Email
info@pbpharm.com
Country
China
ProdList
487
Advantage
55
Chengdu Huachun Technology Co., Ltd
Tel
400-1166-196 15982826727
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
14603
Advantage
60
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Anhui kuer Bioengineering Co., Ltd
Tel
0551-65171243 13856024262
Email
kuer@kuerhuaxue.com
Country
China
ProdList
2992
Advantage
55
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9751
Advantage
58
Shanghai Zhen Li Biological Technology Co., Ltd
Tel
021-16621358918; 18516310516
Fax
13045646768
Email
zhenlipharma888@163.com
Country
China
ProdList
19035
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Maanshan geneyan biotech Co.,LTD
Tel
18913822354
Email
market@geneyan-bio.com
Country
China
ProdList
300
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
10063
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
Hefei Bomei Biotechnology Co., Ltd.
Tel
13739298932
Email
531626407@qq.com
Country
China
ProdList
3010
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
ROSEWA HOLDING GROUP CO.,LIMITED
Tel
+86-023-62871537
Email
sales@rosewachem.com
Country
China
ProdList
2803
Advantage
58
NewCan Biotech Limited
Tel
+86-0571-86912261 +8613735419629
Email
sales@newcanbio.com
Country
China
ProdList
9985
Advantage
58
Dideu Industries Group Limited
Tel
+86-29-89586680 +86-15129568250
Email
1026@dideu.com
Country
China
ProdList
20284
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Henan Weituxi Chemical Technology Co., Ltd.
Tel
0371-63284658 18135795563
Fax
QQ:2885349392
Email
2885349392@qq.com
Country
China
ProdList
9989
Advantage
58
Nanjing Baifuli Technology Co., Ltd.
Tel
+86-15335185688
Email
sales@unisyn.cn
Country
CHINA
ProdList
332
Advantage
58
Hubei xin bonus chemical co. LTD
Tel
86-13657291602
Fax
027-59338440
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
22963
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Hefei Stongbio Co.,Ltd.
Tel
15555170917
Email
sales@stongbio.com
Country
China
ProdList
509
Advantage
58
ShangHai Anpel Co, Ltd.
Tel
18501792038 18502138905
Email
shanpel@anpel.com.cn
Country
China
ProdList
9611
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 18679456698
Email
mingxinzhu@huidabiotech.com
Country
China
ProdList
2975
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
Advantage
58
Krain Pharmaceutical Technology CO.,Ltd
Tel
18252089365
Email
Krain_kerun@163.com
Country
China
ProdList
2507
Advantage
58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Fax
021-5161 3951
Email
sales2@sunwaypharm.com
Country
China
ProdList
44119
Advantage
58
Shanghai fantai biology science and technology co., ltd
Tel
15601885736
Email
2114786541@qq.com
Country
China
ProdList
206
Advantage
58
TCI (Shanghai) Chemical Trading Co., Ltd.
Tel
021-61109150
Fax
021-61105897
Email
sales@tcisct.com
Country
China
ProdList
29668
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Nanjing Yili Biotechnology Co., Ltd.
Tel
15380789538
Email
2885743537@qq.com
Country
China
ProdList
8205
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
15921930842 15921930842
Email
yh-wang@univ-bio.com
Country
China
ProdList
25004
Advantage
58
Jiangsu Synthgene Biotechnology Co.,Ltd.
Tel
15852554546
Email
starre@syngenebio.com
Country
China
ProdList
901
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-0571-89903882 15990081639
Email
sunshixuan@huidabiotech.com
Country
China
ProdList
3705
Advantage
58
More
Less

View Lastest Price from 8-OXO-2'-DEOXYGUANOSINE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
8-OXO-2'-DEOXYGUANOSINE 88847-89-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26

88847-89-6, 8-OXO-2'-DEOXYGUANOSINERelated Search:

8-OXO-2'-DEOXYGUANOSINE Loxoribine 8-Benzyloxyguanosine Guanine Purine 7-propyl-8-oxoguanosine 8-HYDROXYGUANOSINE 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-8-OXO-2'-DEOXYGUANOSINE, 3'-[(2-CYANOETHYL)-(N,N-DIISOPROPYL)]PHOSPHORAMIDITE 8-ALLYLOXY-3'-O-[(DIISOPROPYLAMINO)(2-CYANOETHOXY)PHOSPHINO]-5'-O-(4,4'-DIMETHOXYTRITYL)-N2-[(DIMETHYLAMINO)METHYLIDINE]-2'-DEOXYGUANOSINE 8-ALLYLOXY-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE 8-ALLYLOXY-2'-DEOXYGUANOSINE Tri-O-acetyl-8-(allyloxy)guanosine 5'-O-(DIMETHOXYTRITYL)-8-HYDROXY-N2-ISOBUTRYL-2'-DEOXYGUANOSINE 8-BENZYLOXY-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE 8-HYDROXY-N2-ISOBUTRYL-2'-DEOXYGUANOSINE 8-ALLYLOXY-N2-(DMF)-2'-DEOXYGUANOSINE 8-Benzyloxy-2'-deoxy-D-guanosine 8-(Allyloxy)guanosine

  • 2'-Deoxy-8-oxoguanosine
  • 7,8-Dihydro-8-oxo-2'-deoxyguanosine
  • 8-Oxo-7,8-dihydro-2'-deoxyguanosine
  • 8-Oxo-7,8-dihydrodeoxyguanosine
  • 2'-Deoxy-8-oxo-D-guanosine
  • 8-Oxo-7,8-dihydro-2μ-deoxyguanosine, 8-Oxo-dG
  • 2'-Deoxy-8-hydroxyguanosine
  • 8-Oxodeoxyguanosine
  • 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
  • 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-3,7-dihydropurine-6,8-quinone
  • 2-azanyl-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
  • 8-Hydroxy-2′-deoxyguanosine,8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
  • 8-Hydroxy-2'-deoxyguanosineDiscontinued See O850250
  • 2-AMino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione
  • Guanosine,2'-deoxy-7,8-dihydro-8-oxo-
  • 7,8-dihydro-2’-deoxy-8-oxo-guanosin
  • 2-Amino-9-((2R,4S,5R)
  • -3H-purine-6,8(7H,9H)
  • 8-Oxo-2'-deoxyguanosine (8-Oxo-dG)
  • 7,8-dihydro-2’-deoxy-8-oxoguanosine
  • 8-hydroxydeoxyguanosine
  • 8-oxo-7-hydrodeoxyguanosine
  • 8-Hydroxy-desoxyguanosine
  • 8-OXO-2'-DEOXYGUANOSINE USP/EP/BP
  • -deoxyguanosine
  • 8-Hydroxy-2'-dG
  • 8-Hydroxy-dG
  • 8-HYDROXY-2'-DEOXYGUANOSINE UNLABELED 25 UG/ML IN WATER
  • Inhibitor,8Hydroxy2'deoxyguanosine,inhibit,Endogenous Metabolite,8 Hydroxy 2' deoxyguanosine
  • 2-amino-8-hydroxy-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
  • 8-oxo-2'-deoxyGuanosine
  • 2'-Deoxy-7,8-dihydro-8-oxoguanosine
  • 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,7,8,9-tetrahydro-3H-purine-6,8-dione
  • 8-Hydroxy-2'-deoxyguanosine
  • 2’-Deoxy-8-oxoguanosine
  • 8-Hydroxy-2'-deoxyguanosine (8-OHdG）
  • *Carisoprodol Impurity 4 (Carisoprodol EP Impurity D)(Meprobamate)
  • Rabbit Anti-8-OHdG (DNA/RNA Damage) antibody
  • 8-Hydroxy-2''-deoxyguanosine, Oxidative stress biomarker
  • 8-Hydroxy-2''-deoxyguanosine
  • 8-Hydroxy-2''-deoxyguanosine, 10 mM in DMSO
  • Mouse 8-Hydroxy-desoxyguanosine elisa kit
  • 8-Hydroxy-2＇-deoxyguanosine
  • 8-Oxo-2’-deoxyguanosine
  • 8-Hydroxy-2'-deoxyguanosine - [H70903]
  • 88847-89-6
  • 8847-89-6
  • Bases & Related Reagents
  • Labeling and Diagnostics Reagents
  • Nucleotides
  • Heterocycles