ChemicalBook > CAS DataBase List > 8-OXO-2'-DEOXYGUANOSINE

8-OXO-2'-DEOXYGUANOSINE

Product Name
8-OXO-2'-DEOXYGUANOSINE
CAS No.
88847-89-6
Chemical Name
8-OXO-2'-DEOXYGUANOSINE
Synonyms
8-hydroxydeoxyguanosine;8-Hydroxy-dG;-deoxyguanosine;8-Hydroxy-2'-dG;8-Oxodeoxyguanosine;2-Amino-9-((2R,4S,5R);-3H-purine-6,8(7H,9H);2'-Deoxy-8-oxoguanosine;8-OXO-2'-DEOXYGUANOSINE;8-oxo-2'-deoxyGuanosine
CBNumber
CB6269667
Molecular Formula
C10H13N5O5
Formula Weight
283.24
MOL File
88847-89-6.mol
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8-OXO-2'-DEOXYGUANOSINE Property

Melting point:
217-220°C
Density 
2.25±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO (up to 10 mg/ml).
form 
White to off-white solid.
pka
7.86±0.20(Predicted)
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
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Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
MF8782675
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H5653
Product name
8-Hydroxy-2′-deoxyguanosine
Purity
≥98% (TLC)
Packaging
1mg
Price
$90.5
Updated
2024/03/01
Sigma-Aldrich
Product number
H5653
Product name
8-Hydroxy-2′-deoxyguanosine
Purity
≥98% (TLC)
Packaging
5mg
Price
$312
Updated
2024/03/01
Cayman Chemical
Product number
89320
Product name
8-Hydroxy-2'-deoxyguanosine
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
89320
Product name
8-Hydroxy-2'-deoxyguanosine
Purity
≥98%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
89320
Product name
8-Hydroxy-2'-deoxyguanosine
Purity
≥98%
Packaging
10mg
Price
$363
Updated
2024/03/01
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8-OXO-2'-DEOXYGUANOSINE Chemical Properties,Usage,Production

Description

8-Oxo-2′-deoxyguanosine (88847-89-6) is a useful marker for DNA damage via a variety of oxidative processes.1?It is a critical biomarker for oxidative stress and carcinogenesis.2,3

Chemical Properties

White Crystalline Solid

Uses

A marker compound indicative of DNA damage associated with mutagenesis and carcinogenesis. Can induce differentiation of Friend murine erythroleukemia cells in vitro.

Uses

8-Hydroxy-2′-deoxyguanosine has been used:

  • as a standard to analyse the oxidative DNA damage in the placenta of normal and abnormal pregnancies by electrochemical detection
  • as a standard for high performance liquid chromatography (HPLC) with electrochemical detection (ECD) measurement
  • as a standard for HPLC and as a urinary marker of oxidative stress in order to assess the potential?antioxidant?activity of green coffee bean extract (GCBE) in vivo
  • as a standard for LC/MS/MS analysis

Definition

ChEBI: Guanosine substituted at the purine 8-position by a hydroxy group. It is used as a biomarker of oxidative DNA damage.

Biochem/physiol Actions

A marker compound typically indicative of DNA damage associated with mutagenesis and carcinogenesis

References

1) Beckman?et al. (1997),?Oxidative decay of DNA; J. Biol. Chem.,?272?19636 2) Andreoli?et al. (2010),?Quantitative determination of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile for healthy volunteers; Biomarkers,?15?221 3) Manini?et al. (2009),?Biomarkers of nucleic acid oxidation, polymorphism in, and expression of, hOGG1 gene in styrene-exposed workers; Toxicol. Lett.,?190?41

8-OXO-2'-DEOXYGUANOSINE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-OXO-2'-DEOXYGUANOSINE Suppliers

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View Lastest Price from 8-OXO-2'-DEOXYGUANOSINE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
8-OXO-2'-DEOXYGUANOSINE 88847-89-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26

88847-89-6, 8-OXO-2'-DEOXYGUANOSINERelated Search:

8-OXO-2'-DEOXYGUANOSINE Loxoribine 8-Benzyloxyguanosine Guanine Purine 7-propyl-8-oxoguanosine 8-HYDROXYGUANOSINE 5'-O-(4,4'-DIMETHOXYTRITYL)-N2-ISOBUTYRYL-8-OXO-2'-DEOXYGUANOSINE, 3'-[(2-CYANOETHYL)-(N,N-DIISOPROPYL)]PHOSPHORAMIDITE 8-ALLYLOXY-3'-O-[(DIISOPROPYLAMINO)(2-CYANOETHOXY)PHOSPHINO]-5'-O-(4,4'-DIMETHOXYTRITYL)-N2-[(DIMETHYLAMINO)METHYLIDINE]-2'-DEOXYGUANOSINE 8-ALLYLOXY-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE 8-ALLYLOXY-2'-DEOXYGUANOSINE Tri-O-acetyl-8-(allyloxy)guanosine 5'-O-(DIMETHOXYTRITYL)-8-HYDROXY-N2-ISOBUTRYL-2'-DEOXYGUANOSINE 8-BENZYLOXY-N2-ISOBUTYRYL-2'-DEOXYGUANOSINE 8-HYDROXY-N2-ISOBUTRYL-2'-DEOXYGUANOSINE 8-ALLYLOXY-N2-(DMF)-2'-DEOXYGUANOSINE 8-Benzyloxy-2'-deoxy-D-guanosine 8-(Allyloxy)guanosine

  • 8-HYDROXY-2'-DEOXYGUANOSINE
  • 2'-Deoxy-8-oxoguanosine
  • 7,8-Dihydro-8-oxo-2'-deoxyguanosine
  • 8-Oxo-7,8-dihydro-2'-deoxyguanosine
  • 8-Oxo-7,8-dihydrodeoxyguanosine
  • 2'-Deoxy-8-oxo-D-guanosine
  • 8-Oxo-7,8-dihydro-2μ-deoxyguanosine, 8-Oxo-dG
  • 2'-Deoxy-8-hydroxyguanosine
  • 8-Oxodeoxyguanosine
  • 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
  • 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]-3,7-dihydropurine-6,8-quinone
  • 2-azanyl-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3,7-dihydropurine-6,8-dione
  • 8-Hydroxy-2′-deoxyguanosine,8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Oxo-dG
  • 8-Hydroxy-2'-deoxyguanosineDiscontinued See O850250
  • 2-AMino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-3H-purine-6,8(7H,9H)-dione
  • Guanosine,2'-deoxy-7,8-dihydro-8-oxo-
  • 7,8-dihydro-2’-deoxy-8-oxo-guanosin
  • 2-Amino-9-((2R,4S,5R)
  • -3H-purine-6,8(7H,9H)
  • 8-Oxo-2'-deoxyguanosine (8-Oxo-dG)
  • 7,8-dihydro-2’-deoxy-8-oxoguanosine
  • 8-hydroxydeoxyguanosine
  • 8-oxo-7-hydrodeoxyguanosine
  • 8-OXO-2'-DEOXYGUANOSINE
  • 8-Hydroxy-desoxyguanosine
  • Mouse 8-Hydroxy-desoxyguanosine elisa kit
  • 8-OXO-2'-DEOXYGUANOSINE USP/EP/BP
  • -deoxyguanosine
  • 8-Hydroxy-2'-dG
  • 8-Hydroxy-dG
  • 8-HYDROXY-2'-DEOXYGUANOSINE UNLABELED 25 UG/ML IN WATER
  • Inhibitor,8Hydroxy2'deoxyguanosine,inhibit,Endogenous Metabolite,8 Hydroxy 2' deoxyguanosine
  • *Carisoprodol Impurity 4 (Carisoprodol EP Impurity D)(Meprobamate)
  • Rabbit Anti-8-OHdG (DNA/RNA Damage) antibody
  • 2-amino-8-hydroxy-9-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one
  • 8-oxo-2'-deoxyGuanosine
  • 2'-Deoxy-7,8-dihydro-8-oxoguanosine
  • 2-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6,7,8,9-tetrahydro-3H-purine-6,8-dione
  • 88847-89-6
  • 8847-89-6
  • Bases & Related Reagents
  • Labeling and Diagnostics Reagents
  • Nucleotides
  • Heterocycles