Loxoribine

Product Name: Loxoribine
CAS No.: 121288-39-9
Chemical Name: Loxoribine
Synonyms: RWJ 21757;Loxoribine;Loxoribine, 10 mM in DMSO;7,8-Dihydro-8-oxo-7-allyl-guanosine;7-Allyl-7,8-dihydro-8-oxoguanosine 95%;7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95;7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine;Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-;7,8-dihydro-8-oxo-7-allyl-guanosine, Loxoribine;Guanosine, 7,8-dihydro-8-oxo-7-(2-propen-1-yl)-
CBNumber: CB7499469
Molecular Formula: C13H17N5O6
Formula Weight: 339.3
MOL File: 121288-39-9.mol

More

Less

Loxoribine Property

Melting point:: 227-230 °C(lit.)
Density: 1.92±0.1 g/cm3(Predicted)
storage temp.: Desiccate at +4°C
solubility: Soluble in DMSO (up to 25 mg/ml).
form: White to off-white solid.
pka: 10.29±0.20(Predicted)
color: White
optical activity: [α]21/D 32°, c = 1 in H2O
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

More

Less

Safety

WGK Germany: 3
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 496812
Product name: 7-Allyl-7,8-dihydro-8-oxoguanosine
Purity: 95%
Packaging: 50mg
Price: $200.34
Updated: 2025/07/31

Sigma-Aldrich

Product number: 496812
Product name: 7-Allyl-7,8-dihydro-8-oxoguanosine
Purity: 95%
Packaging: 250mg
Price: $496
Updated: 2025/07/31

Cayman Chemical

Product number: 21186
Product name: Loxoribine
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21186
Product name: Loxoribine
Purity: ≥98%
Packaging: 10mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 21186
Product name: Loxoribine
Purity: ≥98%
Packaging: 25mg
Price: $86
Updated: 2024/03/01

More

Less

Loxoribine Chemical Properties,Usage,Production

Description

Loxoribine is a guanosine derivative and an agonist of toll-like receptor 7 (TLR7). It is selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM.. Loxoribine induces proliferation, increases the antibody response to sheep red blood cells, and activates natural killer cell activity against Yac-1 lymphoma cells in murine splenocyte cultures (EC₅₀s = 10-50, 3-20, and 13-22 μM, respectively). Loxoribine (250 μM) increases production of IL-12, IL-23, IL-27, and IL-10 by human monocyte-derived dendritic cells (MoDCs). Loxoribine-treated MoDCs induce higher levels of IL-17 and IFN-γ secretion by co-cultured allogeneic CD4⁺ T cells compared to control MoDCs. Loxoribine (120 mg/kg) reduces the number of pulmonary metastases in the B16 mouse model of melanoma, an effect enhanced by co-administration of IL-2, and exhibits adjuvant activity in mice immunized with a B16 tumor vaccine.

Chemical Properties

White Solid

Uses

7-Allyl-7,8-dihydro-8-oxoguanosine (Loxoribine) is a small-molecule immunostimulant. Loxoribine is a toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine product ion. Loxoribine displays antitumor and antiviral activity in various animal models.

Uses

Loxoribine is a selective toll-like receptor 7 (TLR7) agonist that activates immune cells and increases cytokine production.

Uses

Small-molecule immunostimulants

Biological Activity

Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.

in vivo

Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo^[3].

Animal Model:	8-12 weeks male CBA/J mice^[3]
Dosage:	2 mg
Administration:	Subcutaneous or intravenous injection
Result:	activates murine natural killer (NK) cells in vivo.

IC 50

TLR7

References

[1] FLORIAN HEIL. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily[J]. European Journal of Immunology, 2003, 33 11: 2987-2997. DOI:10.1002/eji.200324238
[2] GOODMAN M G. A new approach to vaccine adjuvants. Immunopotentiation by intracellular T-helper-like signals transmitted by loxoribine.[J]. Pharmaceutical biotechnology, 1995, 6: 581-609.
[3] MARÍA V GIRART. Engagement of TLR3, TLR7, and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12.[J]. Journal of immunology, 2007, 179 6: 3472-3479. DOI:10.4049/jimmunol.179.6.3472
[4] CAMERON R STEWART. Toll-like receptor 7 ligands inhibit influenza A infection in chickens.[J]. Journal of Interferon and Cytokine Research, 2012, 32 1: 46-51. DOI:10.1089/jir.2011.0036
[5] CHENCHEN WANG. The TLR7 agonist induces tumor regression both by promoting CD4⁺T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells.[J]. Oncotarget, 2015: 1779-1789. DOI:10.18632/oncotarget.2757

Loxoribine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Loxoribine Suppliers

Canada 1 China 73 Switzerland 1 United Kingdom 4 United States 15 Global 94

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

T&W GROUP

Tel: 021-61551611 13296011611
Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
ProdList: 9895
Advantage: 58

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Zhengzhou GranLen pharmaceutical Technology Co., Ltd.

Tel: 0371-85513397
Email: info@granlen.com
Country: China
ProdList: 497
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

121288-39-9, LoxoribineRelated Search:

Geldanamycin TYRPHOSTIN AG 1296 Imatinib mesylate 17-AAG 4,5-Diamino-6-hydroxypyrimidine 8-OXO-2'-DEOXYGUANOSINE 2,4-Diamino-5-(formylamino)-6-hydroxypyrimidine 2,4-Diamino-6-hydroxypyrimidine Loxoribine

7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95

Loxoribine

7-Allyl-2-amino-9-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7,9-dihydro-1H-purine-6,8-dione

7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine

RWJ 21757

Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-

7-Allyl-7,8-dihydro-8-oxoguanosine 95%

7,8-Dihydro-8-oxo-7-allyl-guanosine

7-Allyl-7,8-dihydro-8-oxoguanosine (Loxoribine)

Guanosine, 7,8-dihydro-8-oxo-7-(2-propen-1-yl)-

7,8-dihydro-8-oxo-7-allyl-guanosine, Loxoribine

7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95 USP/EP/BP

RWJ-21757,Loxoribine,natural,Toll-like Receptor (TLR),killer,cells,Influenza Virus,Inhibitor,cells,inhibit,TLR-7,MoDCs,RWJ21757

Loxoribine (RW-J-21757), Toll-like receptor 7 (TLR7) agonist

Loxoribine, 10 mM in DMSO

121288-39-9

Heterocyclic Compounds

Bases & Related Reagents

Heterocycles

Nucleotides

Nucleosides

Oligonucleotide Synthesis

Specialty Synthesis