Loxoribine
- Product Name
- Loxoribine
- CAS No.
- 121288-39-9
- Chemical Name
- Loxoribine
- Synonyms
- RWJ 21757;Loxoribine;7,8-Dihydro-8-oxo-7-allyl-guanosine;7-Allyl-7,8-dihydro-8-oxoguanosine 95%;7-ALLYL-7 8-DIHYDRO-8-OXOGUANOSINE 95;7,8-Dihydro-8-oxo-7-(2-propenyl)guanosine;Guanosine, 7,8-dihydro-8-oxo-7-(2-propenyl)-;7,8-dihydro-8-oxo-7-allyl-guanosine, Loxoribine;Guanosine, 7,8-dihydro-8-oxo-7-(2-propen-1-yl)-;7-Allyl-7,8-dihydro-8-oxoguanosine (Loxoribine)
- CBNumber
- CB7499469
- Molecular Formula
- C13H17N5O6
- Formula Weight
- 339.3
- MOL File
- 121288-39-9.mol
Loxoribine Property
- Melting point:
- 227-230 °C(lit.)
- Density
- 1.92±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- Soluble in DMSO (up to 25 mg/ml).
- form
- White to off-white solid.
- pka
- 10.29±0.20(Predicted)
- color
- White
- optical activity
- [α]21/D 32°, c = 1 in H2O
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety
- WGK Germany
- 3
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 496812
- Product name
- 7-Allyl-7,8-dihydro-8-oxoguanosine
- Purity
- 95%
- Packaging
- 50mg
- Price
- $82.4
- Updated
- 2024/03/01
- Product number
- 496812
- Product name
- 7-Allyl-7,8-dihydro-8-oxoguanosine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $192.4
- Updated
- 2024/03/01
- Product number
- 21186
- Product name
- Loxoribine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21186
- Product name
- Loxoribine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 21186
- Product name
- Loxoribine
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $86
- Updated
- 2024/03/01
Loxoribine Chemical Properties,Usage,Production
Description
Loxoribine is a guanosine derivative and an agonist of toll-like receptor 7 (TLR7). It is selective for TLR7 over other human TLRs in a cell-based reporter assay at 1 mM.. Loxoribine induces proliferation, increases the antibody response to sheep red blood cells, and activates natural killer cell activity against Yac-1 lymphoma cells in murine splenocyte cultures (EC50s = 10-50, 3-20, and 13-22 μM, respectively). Loxoribine (250 μM) increases production of IL-12, IL-23, IL-27, and IL-10 by human monocyte-derived dendritic cells (MoDCs). Loxoribine-treated MoDCs induce higher levels of IL-17 and IFN-γ secretion by co-cultured allogeneic CD4+ T cells compared to control MoDCs. Loxoribine (120 mg/kg) reduces the number of pulmonary metastases in the B16 mouse model of melanoma, an effect enhanced by co-administration of IL-2, and exhibits adjuvant activity in mice immunized with a B16 tumor vaccine.
Chemical Properties
White Solid
Uses
7-Allyl-7,8-dihydro-8-oxoguanosine (Loxoribine) is a small-molecule immunostimulant. Loxoribine is a toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine product ion. Loxoribine displays antitumor and antiviral activity in various animal models.
Uses
Loxoribine is a selective toll-like receptor 7 (TLR7) agonist that activates immune cells and increases cytokine production.
Uses
Small-molecule immunostimulants
Biological Activity
Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.
References
1) Heil?et al.?(2003),?The Tool-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily; Eur. J. Immunol.,?33?2987 2) Goodman?et al.?(1995),?A new approach to vaccine adjuvants. Immunopotentiation by intracellular T-helper-like signals transmitted by loxoribine;?Pharm. Biotechnol.,?6?581 3) Girart?et al.?(2007), Engagement of TLR3, TLR7 and NKG2D regulate IFN-gamma secretion but not NKG2D-mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12; J. Immunol.,?179?3472 4) Stewart?et al.?(2012),?Toll-like receptor 7 ligands inhibit influenza A infection in chickens; J. Interferon Cytokine Res,,?32?46 5) Wang?et al.?(2015),?The TLR7 agonist induces tumor regression both by promoting CD4-T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells; Oncotarget,?6?1779
Loxoribine Preparation Products And Raw materials
Raw materials
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