1-Methyl-1H-pyrazol-3(2H)-one

Product Name: 1-Methyl-1H-pyrazol-3(2H)-one
CAS No.: 52867-35-3
Chemical Name: 1-Methyl-1H-pyrazol-3(2H)-one
Synonyms: 1-Methyl-1,2-dihydro-3H-pyrazol-3-one;EOS-62072;1-Methyl-3-pyrazolone;1-Methylpyrazol-3(2H)-one;1-Methyl-1H-pyrazol-3(2H);1-methyl-3-hydroxypyrazole;3-Hydroxy-1-methylpyrazole;1-METHYL-1H-PYRAZOL-3-OL(WX900134);1-methyl-2,3-dihydro-1H-pyrazol-3-one;3H-Pyrazol-3-one, 1,2-dihydro-1-methyl-
CBNumber: CB62710376
Molecular Formula: C4H6N2O
Formula Weight: 98.1
MOL File: 52867-35-3.mol

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1-Methyl-1H-pyrazol-3(2H)-one Property

Melting point:: 124-128°C
Density: 1.146±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 8.98±0.70(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C4H6N2O/c1-6-3-2-4(7)5-6/h2-3H,1H3,(H,5,7)
InChIKey: WIISOYLZJJYTHT-UHFFFAOYSA-N
SMILES: N1(C)C=CC(=O)N1

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Safety

Hazard Codes: Xi
Risk Statements: 37/38-41
Safety Statements: 26-39
WGK Germany: 3
HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 777846
Product name: 3-Hydroxy-1-methyl-1H-pyrazole
Purity: 96%
Packaging: 1g
Price: $125.13
Updated: 2025/07/31

TRC

Product number: M336238
Product name: 1-Methyl-1H-pyrazol-3(2H)-one
Packaging: 2.5g
Price: $155
Updated: 2021/12/16

Ark Pharm

Product number: P000723451
Product name: 1-Methyl-1H-pyrazol-3(2H)-one
Purity: 98%
Packaging: 10g
Price: $200
Updated: 2021/12/16

Ark Pharm

Product number: P000723451
Product name: 1-Methyl-1H-pyrazol-3(2H)-one
Purity: 98%
Packaging: 25g
Price: $356
Updated: 2021/12/16

AK Scientific

Product number: 7479AB
Product name: 3-Hydroxy-1-methyl-1H-pyrazole
Packaging: 10g
Price: $369
Updated: 2021/12/16

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1-Methyl-1H-pyrazol-3(2H)-one Chemical Properties,Usage,Production

Synthesis

5788-17-0

52867-35-3

Example 7: General procedure for the synthesis of 1-methyl-1H-pyrazol-3(2H)-one from methyl 3-methoxyacrylate and monomethylhydrazine. In a 250 mL flask, 70 g of methanol and 60.5 g (0.46 mol) of 35% concentration of monomethylhydrazine aqueous solution were first added and the reaction temperature was kept at 25 °C. Subsequently, 47.8 g (0.40 mol) of methyl 3-methoxyacrylate was slowly added dropwise over 25 min. The pH of the reaction mixture was maintained at 12 by parallel dropwise addition of a 17% concentration of aqueous NaOH solution during the dropwise addition and during subsequent stirring for 6 h. A total of 97.5 g of NaOH solution was consumed for this process. The yield of the target product 1-methyl-1H-pyrazol-3(2H)-one was 75% when the reaction reached 100% conversion. The ratio of 3-hydroxy isomer to 5-hydroxy isomer in the product was ≥15:1.

References

[1] Patent: US6392058, 2002, B1

1-Methyl-1H-pyrazol-3(2H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Methyl-1H-pyrazol-3(2H)-one Suppliers

China 82 India 1 United States 6 Global 89

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
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Country: China
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Country: China
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Nantong MYBio-pharm. Co., Ltd.

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Cool Pharm, Ltd

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Sigma-Aldrich

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JW & Y Pharmlab Co., Ltd.

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Shanghai Send Pharmaceutical Technology Co., Ltd.

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52867-35-3, 1-Methyl-1H-pyrazol-3(2H)-oneRelated Search:

1-Methyl-1H-pyrazol-3(2H)

1-Methyl-1,2-dihydro-3H-pyrazol-3-one

1-Methyl-3-pyrazolone

3-Hydroxy-1-methylpyrazole

EOS-62072

1-METHYL-1H-PYRAZOL-3-OL(WX900134)

1-methyl-2,3-dihydro-1H-pyrazol-3-one

1-Methylpyrazol-3(2H)-one

3H-Pyrazol-3-one, 1,2-dihydro-1-methyl-

1-methyl-3-hydroxypyrazole

52867-35-3