2,6-DIMETHYL-4-CYANOPYRIDINE
- Product Name
- 2,6-DIMETHYL-4-CYANOPYRIDINE
- CAS No.
- 39965-81-6
- Chemical Name
- 2,6-DIMETHYL-4-CYANOPYRIDINE
- Synonyms
- EOS-61035;4-CYANO-2,6-LUTIDINE;2,6-DIMETHYL-4-CYANOPYRIDINE;4-Cyano-2,6-dimethylpyridine;2,6-Dimethylisonicotinonitrile;2,6-Dimethyl-4-pyridinecarbonitrile;2,6-Dimethylpyridine-4-carbonitrile;4-Pyridinecarbonitrile, 2,6-dimethyl-;2,6-dimethylisonicotinonitrile(SALTDATA: FREE);2,6-DIMETHYL-4-CYANOPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB6271088
- Molecular Formula
- C8H8N2
- Formula Weight
- 132.16
- MOL File
- 39965-81-6.mol
2,6-DIMETHYL-4-CYANOPYRIDINE Property
- Melting point:
- 80-82℃
- Boiling point:
- 229℃
- Density
- 1.05
- Flash point:
- 92℃
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 3.30±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CBR01586
- Product name
- 2,6-Dimethylisonicotinonitrile
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $356
- Updated
- 2025/07/31
- Product number
- FD54355
- Product name
- 2,6-Dimethyl-4-cyanopyridine
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FD54355
- Product name
- 2,6-Dimethyl-4-cyanopyridine
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD54355
- Product name
- 2,6-Dimethyl-4-cyanopyridine
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 3H37-1-U5
- Product name
- 2,6-Dimethylisonicotinonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $112
- Updated
- 2021/12/16
2,6-DIMETHYL-4-CYANOPYRIDINE Chemical Properties,Usage,Production
Uses
2,?6-?Dimethylisonicotinon?itrile is used in the synthetic preparation of 2-ethylthioisonicotinamide.
Synthesis
557-21-1
5093-70-9
39965-81-6
The general procedure for the synthesis of 2,6-dimethyl-4-cyanopyridine from zinc cyanide and 4-bromo-2,6-dimethylpyridine is as follows: Scheme 4, Step A: Zinc cyanide (3.82 g, 31.9 mmol) was added to a solution of DMF (40 mL) containing 4-bromo-2,6-dimethylpyridine (5.09 g, 26.5 mmol) under nitrogen protection. After degassing the stirred suspension by nitrogen bubbling for 15 min, tetrakis(triphenylphosphine)palladium(0) (1.54 g, 1.33 mmol) was added. The reaction mixture was heated at 120 °C for 5.5 h, subsequently cooled to room temperature and diluted with EtOAc (150 mL). The solids were removed by filtration through filter paper and the filter cake was washed with EtOAc (50 mL). The organic filtrate and washings were combined and washed sequentially with 15% aqueous NH3 (2 x 50 mL), water (50 mL) and saturated aqueous NaCl. The organic phase was dried with Na2SO4, filtered and concentrated under reduced pressure to give a light yellow solid. The crude product was purified by rapid chromatography on silica gel with a gradient ratio of hexane/ethyl acetate (9:1 to 1:1) as eluent. The purified chromatographic fractions were combined and concentrated under reduced pressure to give 2,6-dimethyl-4-cyanopyridine (2.79 g, 77% yield). 1H NMR (CDCl3): δ 2.61 (s, 6H), 7.21 (s, 2H).
References
[1] Patent: WO2017/27343, 2017, A1. Location in patent: Page/Page column 34; 35
[2] Patent: WO2017/27345, 2017, A1. Location in patent: Page/Page column 17; 34-35
[3] Journal of Organic Chemistry, 2017, vol. 82, # 13, p. 7040 - 7044
2,6-DIMETHYL-4-CYANOPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-DIMETHYL-4-CYANOPYRIDINE manufacturers
- Product
- 2,6-DIMETHYL-4-CYANOPYRIDINE 39965-81-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-25
- Product
- 2,6-DIMETHYL-4-CYANOPYRIDINE 39965-81-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg，5kg，100kg
- Release date
- 2019-08-06