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GSK2194069

Product Name
GSK2194069
CAS No.
1332331-08-4
Chemical Name
GSK2194069
Synonyms
GSK2194069;GSK2194069 >=97% (HPLC);GSK2194069 (GSK 2194069;4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one;(S)-4-(4-(benzofuran-5-yl)phenyl)-5-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one;3H-1,2,4-Triazol-3-one, 4-[4-(5-benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-
CBNumber
CB62715634
Molecular Formula
C25H24N4O3
Formula Weight
428.48
MOL File
1332331-08-4.mol
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GSK2194069 Property

Density 
1.44±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF:30.0(Max Conc. mg/mL);70.01(Max Conc. mM)
DMSO:54.28(Max Conc. mg/mL);126.68(Max Conc. mM)
Ethanol:4.91(Max Conc. mg/mL);11.46(Max Conc. mM)
form 
powder
pka
6.15±0.20(Predicted)
color 
white to light brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1259
Product name
GSK2194069
Purity
≥97% (HPLC)
Packaging
5MG
Price
$196
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1259
Product name
GSK2194069
Purity
≥97% (HPLC)
Packaging
25MG
Price
$787
Updated
2023/06/20
Cayman Chemical
Product number
20022
Product name
GSK2194069
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20022
Product name
GSK2194069
Purity
≥98%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
20022
Product name
GSK2194069
Purity
≥98%
Packaging
5mg
Price
$169
Updated
2024/03/01
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GSK2194069 Chemical Properties,Usage,Production

Uses

GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor.

Biochem/physiol Actions

GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC50 of 15 ± 0.5 nM.

storage

Store at +4°C

GSK2194069 Preparation Products And Raw materials

Raw materials

Preparation Products

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GSK2194069 Suppliers

China 43 United Kingdom 1 United States 10 Global 54
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5729
Advantage
77

1332331-08-4, GSK2194069Related Search:


  • GSK2194069
  • 4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
  • GSK2194069 (GSK 2194069
  • 3H-1,2,4-Triazol-3-one, 4-[4-(5-benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-
  • GSK2194069 >=97% (HPLC)
  • (S)-4-(4-(benzofuran-5-yl)phenyl)-5-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one
  • 1332331-08-4