GSK2194069
- Product Name
- GSK2194069
- CAS No.
- 1332331-08-4
- Chemical Name
- GSK2194069
- Synonyms
- GSK2194069;GSK2194069 >=97% (HPLC);GSK2194069 (GSK 2194069;4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one;(S)-4-(4-(benzofuran-5-yl)phenyl)-5-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-2,4-dihydro-3H-1,2,4-triazol-3-one;3H-1,2,4-Triazol-3-one, 4-[4-(5-benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-
- CBNumber
- CB62715634
- Molecular Formula
- C25H24N4O3
- Formula Weight
- 428.48
- MOL File
- 1332331-08-4.mol
GSK2194069 Property
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF:30.0(Max Conc. mg/mL);70.01(Max Conc. mM)
DMSO:54.28(Max Conc. mg/mL);126.68(Max Conc. mM)
Ethanol:4.91(Max Conc. mg/mL);11.46(Max Conc. mM) - form
- powder
- pka
- 6.15±0.20(Predicted)
- color
- white to light brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1259
- Product name
- GSK2194069
- Purity
- ≥97% (HPLC)
- Packaging
- 5MG
- Price
- $196
- Updated
- 2023/06/20
- Product number
- SML1259
- Product name
- GSK2194069
- Purity
- ≥97% (HPLC)
- Packaging
- 25MG
- Price
- $787
- Updated
- 2023/06/20
- Product number
- 20022
- Product name
- GSK2194069
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20022
- Product name
- GSK2194069
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 20022
- Product name
- GSK2194069
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $169
- Updated
- 2024/03/01
GSK2194069 Chemical Properties,Usage,Production
Uses
GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor.
Biochem/physiol Actions
GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC50 of 7.7 ± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC50 of 15 ± 0.5 nM.
storage
Store at +4°C
GSK2194069 Preparation Products And Raw materials
Raw materials
Preparation Products
GSK2194069 Suppliers
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
- Advantage
- 58
- Tel
- 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 9923
- Advantage
- 65
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4660
- Advantage
- 60
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 52924
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@advtechind.com
- Country
- United States
- ProdList
- 6075
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@apexbt.com
- Country
- United States
- ProdList
- 6251
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
- Tel
- --
- Fax
- --
- chemicals@usbio.net
- Country
- United States
- ProdList
- 6214
- Advantage
- 80