ChemicalBook > CAS DataBase List > Fmoc-3VVD-OH

Fmoc-3VVD-OH

Product Name
Fmoc-3VVD-OH
CAS No.
863971-44-2
Chemical Name
Fmoc-3VVD-OH
Synonyms
(5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid;FMOC-3AA-OH;Fmoc-3AA-orl;Fmoc-3vvd-OH;4-[(2-{2-[(9H;Tripeptide (MMAE-3);Fmoc-MeVal-Val-Dil-OH;Fmoc-Meval-val-dolaisoleucine-OH;Fmoc-3vvd-OH （Fmoc-MeVal-Val-Dil-OH）;Inhibitor,antibody-drug,ADC,FMOC3VVDOH,ADC Linkers,non-cleavable,inhibit,conjugates,Antibody-drug conjugates linkers,FMOC 3VVD OH
CBNumber
CB62715760
Molecular Formula
C36H51N3O7
Formula Weight
637.81
MOL File
863971-44-2.mol
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Fmoc-3VVD-OH Property

Boiling point:
793.0±60.0 °C(Predicted)
Density 
1.144±0.06 g/cm3(Predicted)
solubility 
DMSO: ≥ 37 mg/mL (58.01 mM)
pka
4.08±0.10(Predicted)
form 
Solid
color 
White to off-white
Water Solubility 
Water: < 0.1 mg/mL (insoluble)
InChIKey
JDMOCVJBADMSJP-FCUBIXSHSA-N
SMILES
C(NC(=O)[C@H](C(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C)(=O)[C@H](C(C)C)N([C@H]([C@H](OC)CC(O)=O)[C@@H](C)CC)C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-M2761
Product name
Fmoc-3VVD-OH
Purity
≥99.0%
Packaging
500mg
Price
$2500
Updated
2021/12/16
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Fmoc-3VVD-OH Chemical Properties,Usage,Production

Description

Fmoc-3vvd-OH, chemically known as (5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-methoxy-4,10-dimethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid, is an antibody-drug conjugate (ADC) linker. Fmoc-3vvd-OH is also an intermediate in the synthesis of MMAE. The Fmoc protecting group can be removed with a base (usually piperidine) to reveal the methylated N-terminus of the peptide.

Uses

Fmoc-3VVD-OH is a cleavable ADC linker for antibody-drug conjugate (ADC) synthesis.

Biological Activity

Fmoc-3VVD-OH is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

in vivo

ADCs consist of antibodies linked to ADC cytotoxins through ADC linkers.

target

Cleavable

Fmoc-3VVD-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-3VVD-OH Suppliers

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863971-44-2, Fmoc-3VVD-OHRelated Search:


  • (5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
  • Fmoc-3AA-orl
  • FMOC-3AA-OH
  • Fmoc-3vvd-OH
  • Tripeptide (MMAE-3)
  • Fmoc-Meval-val-dolaisoleucine-OH
  • (5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
  • L-Valinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-
  • N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-L- valinamide
  • (5S,8S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid
  • Fmoc-MeVal-Val-Dil-OH
  • Inhibitor,antibody-drug,ADC,FMOC3VVDOH,ADC Linkers,non-cleavable,inhibit,conjugates,Antibody-drug conjugates linkers,FMOC 3VVD OH
  • 4-[(2-{2-[(9H
  • Fmoc-3vvd-OH （Fmoc-MeVal-Val-Dil-OH）
  • 863971-44-2
  • ADCs Linkers
  • ADCs
  • ADC LINKER