Fmoc-3VVD-OH

Product Name: Fmoc-3VVD-OH
CAS No.: 863971-44-2
Chemical Name: Fmoc-3VVD-OH
Synonyms: (5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid;FMOC-3AA-OH;Fmoc-3AA-orl;Fmoc-3vvd-OH;4-[(2-{2-[(9H;Tripeptide (MMAE-3);Fmoc-MeVal-Val-Dil-OH;Fmoc-Meval-val-dolaisoleucine-OH;Fmoc-3vvd-OH （Fmoc-MeVal-Val-Dil-OH）;Inhibitor,antibody-drug,ADC,FMOC3VVDOH,ADC Linkers,non-cleavable,inhibit,conjugates,Antibody-drug conjugates linkers,FMOC 3VVD OH
CBNumber: CB62715760
Molecular Formula: C36H51N3O7
Formula Weight: 637.81
MOL File: 863971-44-2.mol

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Fmoc-3VVD-OH Property

Boiling point:: 793.0±60.0 °C(Predicted)
Density: 1.144±0.06 g/cm3(Predicted)
solubility: DMSO: ≥ 37 mg/mL (58.01 mM)
pka: 4.08±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Water: < 0.1 mg/mL (insoluble)
InChIKey: JDMOCVJBADMSJP-FCUBIXSHSA-N
SMILES: C(NC(=O)[C@H](C(C)C)N(C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O)C)(=O)[C@H](C(C)C)N([C@H]([C@H](OC)CC(O)=O)[C@@H](C)CC)C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-M2761
Product name: Fmoc-3VVD-OH
Purity: ≥99.0%
Packaging: 500mg
Price: $2500
Updated: 2021/12/16

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Fmoc-3VVD-OH Chemical Properties,Usage,Production

Description

Fmoc-3vvd-OH, chemically known as (5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-methoxy-4,10-dimethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid, is an antibody-drug conjugate (ADC) linker. Fmoc-3vvd-OH is also an intermediate in the synthesis of MMAE. The Fmoc protecting group can be removed with a base (usually piperidine) to reveal the methylated N-terminus of the peptide.

Uses

Fmoc-3VVD-OH is a cleavable ADC linker for antibody-drug conjugate (ADC) synthesis.

Biological Activity

Fmoc-3VVD-OH is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

in vivo

ADCs consist of antibodies linked to ADC cytotoxins through ADC linkers.

target

Cleavable

Fmoc-3VVD-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-3VVD-OH Suppliers

China 79 United States 6 Global 85

SuZhou JianHua Pharmaceutical Co. Ltd

Tel: 13666392288
Email: jhyylcj@163.com
Country: China
ProdList: 64
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Chengdu Zen Sunda Bio-pharmaceutical Technology Co., Ltd.

Tel: 19981275275
Email: sales@zsdbiopharm.com
Country: China
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Shanghai Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: 021-58955996
Email: info@chemexpress.com
Country: China
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Jinan Chengquan Chemical Co., Ltd

Tel: 13616405505 13616405505
Email: zhulinsun1@126.com
Country: China
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Huadong Microbiology Co., Ltd.

Tel: 15858880160
Email: dingya@eastchinapharm.com
Country: China
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BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
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Shanghai Topbiochem Technology Co., Ltd

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Email: info@topbiochem.com
Country: China
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Tianjin Chempharmatech Co.,Ltd.

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Fax: qq1405432731
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Country: China
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Hygeia (Chengdu) pharmaceutical technique Co., Ltd

Tel: 028-84502008 13568869383
Fax: 028-66476329
Email: sales@hygeiapharm.com
Country: China
ProdList: 298
Advantage: 55

863971-44-2, Fmoc-3VVD-OHRelated Search:

(5S,9S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,9-diisopropyl-12-Methoxy-4,10-diMethyl-3,6,8-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid

Fmoc-3AA-orl

FMOC-3AA-OH

Fmoc-3vvd-OH

Tripeptide (MMAE-3)

Fmoc-Meval-val-dolaisoleucine-OH

(5S,8S,11S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid

L-Valinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-L-valyl-N-[(1S,2S)-1-[(1R)-2-carboxy-1-methoxyethyl]-2-methylbutyl]-N-methyl-L- valinamide

(5S,8S,12R)-11-((S)-sec-butyl)-1-(9H-fluoren-9-yl)-5,8-diisopropyl-12-methoxy-4,10-dimethyl-3,6,9-trioxo-2-oxa-4,7,10-triazatetradecan-14-oic acid

Fmoc-MeVal-Val-Dil-OH

Inhibitor,antibody-drug,ADC,FMOC3VVDOH,ADC Linkers,non-cleavable,inhibit,conjugates,Antibody-drug conjugates linkers,FMOC 3VVD OH

4-[(2-{2-[(9H

Fmoc-3vvd-OH （Fmoc-MeVal-Val-Dil-OH）

863971-44-2

ADCs Linkers

ADCs

ADC LINKER