ChemicalBook > CAS DataBase List > 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile

Product Name
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
CAS No.
1187595-85-2
Chemical Name
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
Synonyms
2-[1-(Ethylsulfonyl)-3-azetidinylidene]acetonitrile;Baricitinib-010;Baricitinib Intermediates;Baricitinib intermediate 2;[1-(ethylsulfonyl)azetidin-3-ylidene]acetonitrile;2-(1-ETHYLSULFONY)AZETIDIN-3-YLIDENE)ACETONITRILE;(1-Ethanesulfonyl-azetidin-3-ylidene)-acetonitrile;2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile;2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile;2-[1-(ethyl sulfonyl) -3-azacyclobutyl] acetonitrile
CBNumber
CB62715957
Molecular Formula
C7H10N2O2S
Formula Weight
186.23
MOL File
1187595-85-2.mol
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2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Property

Melting point:
67-69°C
Boiling point:
360.8±52.0 °C(Predicted)
Density 
1.33±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
-8.49±0.20(Predicted)
form 
Solid
color 
Off-White to Light Yellow
InChI
InChI=1S/C7H10N2O2S/c1-2-12(10,11)9-5-7(6-9)3-4-8/h3H,2,5-6H2,1H3
InChIKey
HQUIOHSYUKWGOM-UHFFFAOYSA-N
SMILES
C(#N)/C=C1\CN(S(CC)(=O)=O)C\1
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

TRC
Product number
E926540
Product name
2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile
Packaging
5g
Price
$275
Updated
2021/12/16
AK Scientific
Product number
3147AH
Product name
2-[1-(Ethanesulfonyl)azetidin-3-ylidene]acetonitrile
Packaging
25g
Price
$206
Updated
2021/12/16
Apolloscientific
Product number
OR921330
Product name
2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile
Purity
97%
Packaging
25g
Price
$243
Updated
2021/12/16
ChemScene
Product number
CS-M2446
Product name
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
Packaging
25g
Price
$75
Updated
2021/12/16
AK Scientific
Product number
J95359
Product name
2-[1-(Ethanesulfonyl)azetidin-3-ylidene]acetonitrile
Packaging
25g
Price
$160
Updated
2021/12/16
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2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Chemical Properties,Usage,Production

Uses

2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile is an intermediate in the synthesis of Baricitinib, a JAK 1 and 2 inhibitor used in the treatment of rheumatoid arthritis.

Synthesis

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile is synthesized by first treating azetidine-3-ol hydrochloride with an equimolar equivalent of an alkanesulfonyl chloride, preferably ethanesulfonyl chloride, to give l-ethylsulfonylazetidin-3-ol. Preferably, the reaction is performed in a biphasic solution comprising a mixture of an organic phase and a aqueous phase, preferably THF with an aqueous solution which is basic, while maintaining the solution at room temperature or a temperature slightly below room temperature, preferably 20 °C. The reaction is followed to completion using standard monitoring techniques. Typically, the reaction is complete within 1 to 5 hours. The organic layer is removed, preferably by distillation, and the aqueous layer is extracted with an appropriate solvent such as toluene, p-cymene, and CPME. Preferably the extraction solvent is toluene. Alternatively, the toluene extractions can be excluded if recrystallization of 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile is performed.

2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile manufacturers

Jinan Million Pharmaceutical Co., Ltd
Product
2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile 1187595-85-2
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-15
Nanjing Fred Technology Co., Ltd
Product
2-(1-(Ethylsulfonyl)azetidin-3-ylidene)acetonitrile 1187595-85-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-29
Shanghai Joiny Pharmaceutical Co.,LTD
Product
2-[1-(Ethylsulfonyl)-3-azetidinylidene]acetonitrile 1187595-85-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
200kg
Release date
2023-01-16

1187595-85-2, 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrileRelated Search:

Baricitinib 4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

  • 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
  • 2-[1-(Ethylsulfonyl)-3-azetidinylidene]acetonitrile
  • [1-(ethylsulfonyl)azetidin-3-ylidene]acetonitrile
  • 2-[1-(ethanesulfonyl)azetidin-3-ylidene]acetonitrile
  • Acetonitrile, 2-[1-(ethylsulfonyl)-3-azetidinylidene]-
  • (1-Ethanesulfonyl-azetidin-3-ylidene)-acetonitrile
  • Baricitinib intermediates 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile
  • 2-(1-ETHYLSULFONY)AZETIDIN-3-YLIDENE)ACETONITRILE
  • Baricitinib-010
  • 2-(1-(ethylsulfonyl)azetidin-3-ylidene)acetonitrile ISO 9001：2015 REACH
  • Baricitinib Intermediates
  • 2- [1- (Ethylsulfonyl) -3-azacyclobutyryl] acetonitrile
  • 2-[1-(ethyl sulfonyl) -3-azacyclobutyl] acetonitrile
  • Baricitinib intermediate 2
  • 1187595-85-2
  • 1187595-85-2