ChemicalBook > CAS DataBase List > GDC-0994

GDC-0994

Product Name
GDC-0994
CAS No.
1453848-26-4
Chemical Name
GDC-0994
Synonyms
CS-1841;GDC-0994;RG-7842);EOS-60648;Ravoxertinib;GDC-0994;RAVOXERTINIB;RAVOXERTINIB (GDC-0994);GDC 0994;GDC-0994;GDC0994;GDC-0994 (RAVOXERTINIB, RG7842);1-(1S)-1-(3-Fluoro-4-chlorophenyl)-2-hydroxyethyl-4-2-(1-methyl-1H-pyrazol-5-yl)aminopyrimidin-4-yl-2(1H)-pyridinone
CBNumber
CB62716237
Molecular Formula
C21H18ClFN6O2
Formula Weight
440.86
MOL File
1453848-26-4.mol
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GDC-0994 Property

Boiling point:
734.6±70.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥44.1 mg/mL in DMSO; insoluble in H2O; ≥19.2 mg/mL in EtOH
form 
solid
pka
14.03±0.10(Predicted)
color 
White to yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
5mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
10mg
Price
$426
Updated
2024/03/01
TRC
Product number
G299910
Product name
GDC-0994
Packaging
2.5mg
Price
$1105
Updated
2021/12/16
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GDC-0994 Chemical Properties,Usage,Production

Description

GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively. It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.

Uses

GDC-0994 is a potent and orally available ERK12 inhibitor shown to prevent ERK-dependant tumor cell proliferation and survival.

References

[1]. robarge k, schwarz j, blake j, et al. abstract ddt02-03: discovery of gdc-0994, a potent and selective erk1/2 inhibitor in early clinical development. aacr annual meeting, 2014, san diego, ca.

GDC-0994 Preparation Products And Raw materials

Raw materials

Preparation Products

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GDC-0994 Suppliers

China 94 India 1 United States 15 Global 110
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View Lastest Price from GDC-0994 manufacturers

Career Henan Chemical Co
Product
GDC-0994 1453848-26-4
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

1453848-26-4, GDC-0994Related Search:


  • GDC-0994
  • (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one GDC-0994
  • (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
  • 1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-2(1H)-pyridinone
  • Ravoxertinib
  • EOS-60648
  • GDC 0994;GDC-0994;GDC0994
  • CS-1841
  • GDC-0994;RAVOXERTINIB
  • RAVOXERTINIB (GDC-0994)
  • 2(1H)-Pyridinone, 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-
  • RG-7842)
  • 1-(1S)-1-(3-Fluoro-4-chlorophenyl)-2-hydroxyethyl-4-2-(1-methyl-1H-pyrazol-5-yl)aminopyrimidin-4-yl-2(1H)-pyridinone
  • GDC-0994 (RAVOXERTINIB, RG7842)
  • 1453848-26-4
  • C21H18ClFN6O2
  • Inhibitors