ChemicalBook > CAS DataBase List > GDC-0994

GDC-0994

Product Name
GDC-0994
CAS No.
1453848-26-4
Chemical Name
GDC-0994
Synonyms
CS-1841;GDC-0994;RG-7842);EOS-60648;Ravoxertinib;GDC-0994;RAVOXERTINIB;RAVOXERTINIB (GDC-0994);GDC 0994;GDC-0994;GDC0994;GDC-0994 (RAVOXERTINIB, RG7842);1-(1S)-1-(3-Fluoro-4-chlorophenyl)-2-hydroxyethyl-4-2-(1-methyl-1H-pyrazol-5-yl)aminopyrimidin-4-yl-2(1H)-pyridinone
CBNumber
CB62716237
Molecular Formula
C21H18ClFN6O2
Formula Weight
440.86
MOL File
1453848-26-4.mol
More
Less

GDC-0994 Property

Boiling point:
734.6±70.0 °C(Predicted)
Density 
1.45±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≥44.1 mg/mL in DMSO; insoluble in H2O; ≥19.2 mg/mL in EtOH
form 
solid
pka
14.03±0.10(Predicted)
color 
White to yellow
More
Less

Safety

HS Code 
2933998090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
5mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
21107
Product name
GDC-0994
Purity
≥98%
Packaging
10mg
Price
$426
Updated
2024/03/01
TRC
Product number
G299910
Product name
GDC-0994
Packaging
2.5mg
Price
$1105
Updated
2021/12/16
More
Less

GDC-0994 Chemical Properties,Usage,Production

Description

GDC-0994 is a potent and selective ERK1 and ERK2 inhibitor with IC50 values of 6.1 and 4.1 nM, respectively. It inhibits ERK-dependent p90RSK serine 380 phosphorylation in PMA-stimulated HepG2 cells with an IC50 value of 12 nM. GDC-0994 inhibited growth of HCT116 human colorectal cancer xenograft tumors by 49%, 57%, and 80% at 30, 60, and 100 mg/kg, respectively, when administered orally once daily for 21 days.

Uses

GDC-0994 is a potent and orally available ERK12 inhibitor shown to prevent ERK-dependant tumor cell proliferation and survival.

References

[1]. robarge k, schwarz j, blake j, et al. abstract ddt02-03: discovery of gdc-0994, a potent and selective erk1/2 inhibitor in early clinical development. aacr annual meeting, 2014, san diego, ca.

GDC-0994 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

GDC-0994 Suppliers

China 94 India 1 United States 15 Global 110
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
More
Less

View Lastest Price from GDC-0994 manufacturers

Career Henan Chemical Co
Product
GDC-0994 1453848-26-4
Price
US $2.00/KG
Min. Order
1g
Purity
98%min
Supply Ability
ask
Release date
2020-01-08

1453848-26-4, GDC-0994Related Search:


  • GDC-0994
  • (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one GDC-0994
  • (S)-1-(1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one
  • 1-[(1S)-1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-2(1H)-pyridinone
  • Ravoxertinib
  • EOS-60648
  • GDC 0994;GDC-0994;GDC0994
  • CS-1841
  • GDC-0994;RAVOXERTINIB
  • RAVOXERTINIB (GDC-0994)
  • 2(1H)-Pyridinone, 1-[(1S)-1-(4-chloro-3-fluorophenyl)-2-hydroxyethyl]-4-[2-[(1-methyl-1H-pyrazol-5-yl)amino]-4-pyrimidinyl]-
  • RG-7842)
  • 1-(1S)-1-(3-Fluoro-4-chlorophenyl)-2-hydroxyethyl-4-2-(1-methyl-1H-pyrazol-5-yl)aminopyrimidin-4-yl-2(1H)-pyridinone
  • GDC-0994 (RAVOXERTINIB, RG7842)
  • 1453848-26-4
  • C21H18ClFN6O2
  • Inhibitors