2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

Product Name: 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
CAS No.: 192718-06-2
Chemical Name: 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione
Synonyms: C527;C527 >=98% (HPLC);2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione;2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione;Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-;Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit
CBNumber: CB62719612
Molecular Formula: C17H8FNO3
Formula Weight: 293.25
MOL File: 192718-06-2.mol

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2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Property

Boiling point:: 488.6±47.0 °C(Predicted)
Density: 1.433±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: soluble0.3mg/mL, clear (warmed)
pka: -4.21±0.20(Predicted)
form: powder
color: faint yellow to dark yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 46
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1008
Product name: C527
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $107
Updated: 2022/05/15

Cayman Chemical

Product number: 21771
Product name: C527
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 21771
Product name: C527
Purity: ≥98%
Packaging: 10mg
Price: $143
Updated: 2024/03/01

Cayman Chemical

Product number: 21771
Product name: C527
Purity: ≥98%
Packaging: 25mg
Price: $317
Updated: 2024/03/01

Cayman Chemical

Product number: 21771
Product name: C527
Purity: ≥98%
Packaging: 50mg
Price: $435
Updated: 2024/03/01

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2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Chemical Properties,Usage,Production

Biological Activity

C527 is a pan-DUB enzyme inhibitor with high activity against USP1/UAF1 complex with IC50 value of 0.88 μM.

in vitro

Pretreatment of USP1/UAF1 with C527 resulted in inhibition of its enzyme activity with an IC ₅₀ of 0.88±0.03 μM. C527 inhibits the DUB activity of the USP12/USP46 complex and other DUB enzymes in vitro . However, the IC ₅₀ of C527 for these DUB enzymes was higher in comparison with USP1/UAF1 complex. C527 has considerably less inhibitory effect on UCH-L1 and UCH-L3, a different subclass of DUB enzymes. C527 treatments causes an increase in the levels of Ub-FANCD2 and Ub-FANCI. Pretreatment of cells with the C527 causes an enhancement in the cytoxicity of mitomycin C and camptothecin. C527 treatments lead to an increase in ubiquitinated forms of FANCD2 and FANCI, cause a decrease in homologous recombination activity, and sensitize cells to DNA damaging agents.

target

0.88 μM (USP1)

2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione Suppliers

China 34 United Kingdom 2 United States 8 Global 44

Shanghai Boyle Chemical Co., Ltd.

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BOC Sciences

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Pharmacodia (Beijing) Co.,Ltd

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Lynnchem

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Novachemistry

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192718-06-2, 2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dioneRelated Search:

2-(4-Fluorophenyl)naphtho[2,3-d]oxazole-4,9-dione

2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione

C527

Naphth[2,3-d]oxazole-4,9-dione, 2-(4-fluorophenyl)-

C527 >=98% (HPLC)

Inhibitor,C 527,DUBs,C527,Deubiquitinase,C-527,inhibit

2-(4-Fluorophenyl)phtho[2,3-d]oxazole-4,9-dione

192718-06-2