ChemicalBook > CAS DataBase List > 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt)

1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt)

Product Name: 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt)
CAS No.: 385437-57-0
Chemical Name: 1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt)
Synonyms: DSPE-PEG5000-BIO;DSPE-PEG1000-BIO;DSPE-PEG-2K-Biotin;DSPE-PEG(2000) Biotin;DSPE-MPEG-2000-Biotin;DSPE-PEG-Biotin (MW 2000);DSPE-PEG-Biotin/DSPE-PEG-BIO;Biotin-PEG-DSPE DSPE-PEG-Biotin;DSPE-PEG-Biotin (ammonium salt);DSPE-PEG-Biotin,CAS:385437-57-0
CBNumber: CB62720692
Molecular Formula: (C2H4O)nC54H101N4O12PS.Na
Formula Weight: 0
MOL File: 385437-57-0.mol

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1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt) Property

storage temp.: -20°C
solubility: Ethanol: Soluble: =10 mg/ml
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22723
Product name: DSPE-PEG-Biotin,MW2K
Packaging: 25mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: LIP0003161
Product name: 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE-N-[BIOTINYL(POLYETHYLENE GLYCOL)-2000]AMMONIUM SALT
Purity: 95.00%
Packaging: 5MG
Price: $501.83
Updated: 2021/12/16

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1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt) Chemical Properties,Usage,Production

Description

DSPE-PEG-Biotin, MW 2,000 is a biotin amphipilic material which forms micelles in an aqueous solution and binds selectively with streptavidin and avidin. This polymer is very promising nanocarriers for therapeutic drug delivery, imaging and molecular labeling.

Uses

DSPE-PEG-Biotin, MW 1000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
[2] ZHANG J, LUO Y, ZHAO X, et al. Co-delivery of doxorubicin and the traditional Chinese medicine quercetin using biotin–PEG2000–DSPE modified liposomes for the treatment of multidrug resistant breast cancer[J]. RSC Advances, 2016, 114: 113173-113184. DOI: 10.1039/c6ra24173e
[3] DONGHUA LIU. Tumor Specific Delivery and Therapy by Double-Targeted Nanostructured Lipid Carriers with Anti-VEGFR-2 Antibody[J]. Molecular Pharmaceutics, 2011, 8 6: 2291-2301. DOI: 10.1021/mp200402e
[4] JAKOB WALLNER. An approach for liposome immobilization using sterically stabilized micelles (SSMs) as a precursor for bio-layer interferometry-based interaction studies[J]. Colloids and Surfaces B: Biointerfaces, 2017, 154: Pages 186-194. DOI: 10.1016/j.colsurfb.2017.03.015

1,2-distearoyl-sn-glycero-3-phosphoethanolaMine-N-[biotinyl(polyethylene glycol)-2000] (aMMoniuM salt) Preparation Products And Raw materials

Raw materials

Preparation Products

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