ChemicalBook > CAS DataBase List > Z-THR(TBU)-OH
Z-THR(TBU)-OH
- Product Name
- Z-THR(TBU)-OH
- CAS No.
- 16966-09-9
- Chemical Name
- Z-THR(TBU)-OH
- Synonyms
- Z-THR(TBU)-OH;Cbz-Thr(tBu)-OH;Cbz-L-Thr(tBu)-OH;Linaclotide Impurity 24;O-(tert-Butyl)-N-Cbz-L-threonine;N-((Benzyloxy)Carbonyl)-O-(Tert-Butyl)-L-Threonine, ≥98%;L-Threonine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-;(2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid;(2S,3R)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoicacid
- CBNumber
- CB62729569
- Molecular Formula
- C16H23NO5
- Formula Weight
- 309.36
- MOL File
- 16966-09-9.mol
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Z-THR(TBU)-OH Property
- Boiling point:
- 470.1±45.0 °C(Predicted)
- Density
- 1.152±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- Solid
- pka
- 3.51±0.10(Predicted)
- color
- White to off-white
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Biosynth Carbosynth
- Product number
- FB166469
- Product name
- (2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid
- Packaging
- 25g
- Price
- $65
- Updated
- 2021/12/16
Activate Scientific
- Product number
- AS48433-A
- Product name
- Cbz-O-tert-butyl-L-threonine
- Purity
- 97% ee
- Packaging
- 5G
- Price
- $67
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB166469
- Product name
- (2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid
- Packaging
- 50g
- Price
- $100
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB166469
- Product name
- (2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid
- Packaging
- 100g
- Price
- $160
- Updated
- 2021/12/16
AK Scientific
- Product number
- 5843CQ
- Product name
- (2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoicacid
- Packaging
- 50g
- Price
- $185
- Updated
- 2021/12/16
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Z-THR(TBU)-OH Chemical Properties,Usage,Production
Uses
N-((Benzyloxy)carbonyl)-O-(tert-butyl)-L-threonine is a threonine derivative[1].
Synthesis
52785-41-8
16966-09-9
The general procedure for the synthesis of (2S,3R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid from linaclotide impurity 23 was as follows: z-Thr(tBu)-OMe (169 g) was added to a 2 L beaker with 300 mL of acetone and 600 mL of 1,2-dichloroethane, and the pH was adjusted to 10-11 with 1 M sodium hydroxide solution. After completion of the reaction, the reaction was washed once with 500 mL of ether, 800 mL of ethyl acetate was added, and the pH was adjusted to 2-3 with aqueous citric acid solution.Subsequently, the reaction was washed with 300 mL of water, and then with 300 mL of saturated brine. The organic phase was dried over 100 g of anhydrous sodium sulfate, filtered and concentrated under reduced pressure. To the residue was added 500 mL of ether and dried to obtain Z-Thr(tBu)-OH (130 g) in granular form in 80.3% yield.
References
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368
Z-THR(TBU)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Z-THR(TBU)-OH manufacturers
Sichuan HongRi Pharma-Tech Co.,Ltd
- Product
- Cbz-L-Thr(tBu)-OH 16966-09-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-01-15
Career Henan Chemical Co
- Product
- Z-THR(TBU)-OH 16966-09-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-15
Career Henan Chemical Co
- Product
- Z-THR(TBU)-OH 16966-09-9
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-15