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Z-THR(TBU)-OH

Product Name
Z-THR(TBU)-OH
CAS No.
16966-09-9
Chemical Name
Z-THR(TBU)-OH
Synonyms
Z-THR(TBU)-OH;Cbz-Thr(tBu)-OH;Cbz-L-Thr(tBu)-OH;Linaclotide Impurity 24;O-(tert-Butyl)-N-Cbz-L-threonine;N-((Benzyloxy)Carbonyl)-O-(Tert-Butyl)-L-Threonine, ≥98%;L-Threonine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-;(2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid;(2S,3R)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoicacid
CBNumber
CB62729569
Molecular Formula
C16H23NO5
Formula Weight
309.36
MOL File
16966-09-9.mol
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Z-THR(TBU)-OH Property

Boiling point:
470.1±45.0 °C(Predicted)
Density 
1.152±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
form 
Solid
pka
3.51±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB166469
Product name
(2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid
Packaging
25g
Price
$65
Updated
2021/12/16
Activate Scientific
Product number
AS48433-A
Product name
Cbz-O-tert-butyl-L-threonine
Purity
97% ee
Packaging
5G
Price
$67
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB166469
Product name
(2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid
Packaging
50g
Price
$100
Updated
2021/12/16
AK Scientific
Product number
5843CQ
Product name
(2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoicacid
Packaging
50g
Price
$185
Updated
2021/12/16
Activate Scientific
Product number
AS48433-A
Product name
Cbz-O-tert-butyl-L-threonine
Purity
97% ee
Packaging
25g
Price
$224
Updated
2021/12/16
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Z-THR(TBU)-OH Chemical Properties,Usage,Production

Uses

N-((Benzyloxy)carbonyl)-O-(tert-butyl)-L-threonine is a threonine derivative[1].

Synthesis

52785-41-8

16966-09-9

The general procedure for the synthesis of (2S,3R)-2-(((benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid from linaclotide impurity 23 was as follows: z-Thr(tBu)-OMe (169 g) was added to a 2 L beaker with 300 mL of acetone and 600 mL of 1,2-dichloroethane, and the pH was adjusted to 10-11 with 1 M sodium hydroxide solution. After completion of the reaction, the reaction was washed once with 500 mL of ether, 800 mL of ethyl acetate was added, and the pH was adjusted to 2-3 with aqueous citric acid solution.Subsequently, the reaction was washed with 300 mL of water, and then with 300 mL of saturated brine. The organic phase was dried over 100 g of anhydrous sodium sulfate, filtered and concentrated under reduced pressure. To the residue was added 500 mL of ether and dried to obtain Z-Thr(tBu)-OH (130 g) in granular form in 80.3% yield.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

Z-THR(TBU)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Z-THR(TBU)-OH Suppliers

China 54 India 1 United Kingdom 1 United States 3 Global 59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
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China
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Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
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China
ProdList
39966
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Shanghai GL Peptide Ltd.
Tel
+86-21-61263340; 17609490614 13764994101
Fax
021-61263399
Email
fisherwang@glschina.com
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China
ProdList
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
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China
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Wuxi Asia Peptide Biotechnology Limited Company
Tel
0510-83583050 13771062561
Fax
0510-83583039
Email
willsun@peptide-search.com
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China
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Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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Nanjing Peptide Biotech Ltd.
Tel
025-58361106-805 15951641583
Fax
025-58361106-806
Email
zhao.xu@njpeptide.com
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China
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Chengdu Aminotp Pharmaceutical Technology Co.,Ltd.
Tel
028-85755578 18140172005
Fax
028-85755578
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sales@aminotp.com
Country
China
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298
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Sichuan jiayinglai technology CO.,LTD
Tel
028-028-88457210 18190964009
Fax
QQ3213375147
Email
3054240163@qq.com
Country
China
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Jiaxing Deyi Chemical Co., Ltd.
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86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8596
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View Lastest Price from Z-THR(TBU)-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Cbz-L-Thr(tBu)-OH 16966-09-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-01-15
Career Henan Chemical Co
Product
Z-THR(TBU)-OH 16966-09-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15
Career Henan Chemical Co
Product
Z-THR(TBU)-OH 16966-09-9
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2018-08-15

16966-09-9, Z-THR(TBU)-OHRelated Search:

Z-Thr(TBDMS)-OH Z-THR(TBU)-OH DCHA

  • Z-THR(TBU)-OH
  • N-((Benzyloxy)Carbonyl)-O-(Tert-Butyl)-L-Threonine, ≥98%
  • L-Threonine, O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-
  • Cbz-Thr(tBu)-OH
  • (2S,3R)-2-(((Benzyloxy)carbonyl)amino)-3-(tert-butoxy)butanoic acid
  • (2S,3R)-3-[(2-methylpropan-2-yl)oxy]-2-(phenylmethoxycarbonylamino)butanoicacid
  • O-(tert-Butyl)-N-Cbz-L-threonine
  • Cbz-L-Thr(tBu)-OH
  • Linaclotide Impurity 24
  • 16966-09-9