ChemicalBook > CAS DataBase List > Salcaprozate Sodium

Salcaprozate Sodium

Product Name
Salcaprozate Sodium
CAS No.
203787-91-1
Chemical Name
Salcaprozate Sodium
Synonyms
SNAC;sodium,8-[(2-hydroxybenzoyl)amino]octanoate;Salcaprozate Sodium (SNAC);sodium 8-(2-hydroxybenzamido)octanoate;Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, monosodium salt;E414;Salcaprozate sodium;SNAC reference standard;Chlorotoluron Impurity 3;2,5-Furandione,3-chlorodihydro-,(7R)-
CBNumber
CB62739113
Molecular Formula
C15H22NNaO4
Formula Weight
303.33
MOL File
203787-91-1.mol
More
Less

Salcaprozate Sodium Property

Melting point:
183 - 185°C
storage temp. 
Inert atmosphere,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
InChI
InChI=1S/C15H21NO4.Na.H/c17-13-9-6-5-8-12(13)15(20)16-11-7-3-1-2-4-10-14(18)19;;/h5-6,8-9,17H,1-4,7,10-11H2,(H,16,20)(H,18,19);;
InChIKey
OBKUJEVXEMKQMJ-UHFFFAOYSA-N
SMILES
C(C1C=CC=CC=1O)(=O)NCCCCCCCC(=O)O.[NaH]
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
S085600
Product name
SalcaprozateSodium
Packaging
25mg
Price
$90
Updated
2021/12/16
TRC
Product number
S085600
Product name
SalcaprozateSodium
Packaging
50mg
Price
$160
Updated
2021/12/16
TRC
Product number
S085600
Product name
SalcaprozateSodium
Packaging
250mg
Price
$770
Updated
2021/12/16
AK Scientific
Product number
3779AL
Product name
Salcaprozatesodium
Packaging
5g
Price
$799
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
98951
Product name
Salcaprozatesodium
Packaging
100mg
Price
$190
Updated
2021/12/16
More
Less

Salcaprozate Sodium Chemical Properties,Usage,Production

Description

Salcaprozate sodium (SNAC) is the sodium salt form of salcaprozate, an oral absorption promoter. Salcaprozate sodium may be used as a delivery agent to promote the oral absorption of certain macromolecules with poor bioavailability such as insulin and heparin.It is also used as an excipient in drug formulation as a chemical permeation enhancer (PE) to aid the oral absorption of macromolecules, peptides and proteins such as insulin (diabetes), heparin (heart attacks and angina) and cyanocobalamin (vitamin B12 deficiency and anaemia) which would otherwise have poor bioavailability. SNAC is considered to be safe for human consumption (GRAS) by the FDA.

Chemical Properties

It is a white to off-white crystalline powder, and its solubility in water is approximately 33 mg/mL.

Uses

Salcaprozate Sodium is a drug excipient or inactive ingredient in drug formulations.

Definition

Salcaprozate Sodium (SNAC) is a synthetic N-acetylated amino-acid derivative of salicylic acid. SNAC is a weak acid that display amphiphilicity and surface activity. It was discovered as part of a screen to identify carrier-based PEs that could “chaperone” poorly permeable payloads across the intestine. This compound is the most extensively tested carrier and the only PE approved in an oral formulation designed to improve oral BA, albeit with a small molecule, cyanocobalamin/SNAC. In other preclinical studies, it also improved intestinal permeation of peptides (salmon calcitonin (sCT) and insulin), along with poorly permeable small molecules (e.g., cromolyn). SNAC was tested in many formats: taste-masked liquids, tablets, and soft gelatin capsules. Similar to C10, SNAC can be blended with the active pharmaceutical ingredient (API) using conventional processes, which makes manufacturing uncoated oral tablet dosage forms economic and relatively easy to scale[1].

Side effects

Animal studies of Salcaprozate Sodium (SNAC) showed an associated mortality rate that was only evident at the 2000 mg/kg/day level, 20 per cent in males and 50 per cent in females; there was no clear cause of death. In the Wistar rat study, no mortality was observed at doses up to 1000 mg/kg/d. Clinicopathological parameters included slightly altered electrolyte levels and decreased globulin levels, and slightly higher liver and kidney weights, but no corresponding histopathological changes.Adverse effects of SNAC in Wistar rats were evident at levels up to 1000 mg/kg/d. The results of this study are summarised in the table below.

in vitro

SNAC (12.5-400 μg/mL; 24 h) has no toxicity to Caco-2 cells, and the survival percentage is above 90% when SNAC is 200 μg/mL.
SNAC (50 and 200 μg/mL) improves the apparent permeability coeffcient (Papp) of RA and SA-B by 2.14-fold and 3.68-fold compared with the Papp of SAs solution.

in vivo

SNAC improves the oral absorption of both R1 and SAs and enhances bioavailability in rats.
SNAC (2000 mg/kg/d; oral gavage for 13 weeks) related mortality is evident only at the 2000-mg/kg/d level, 20% among males and 50% among females; no clear cause of death is evident.
SNAC (100-1000 mg/kg/d; oral gavage for 13 weeks) induces no mortality in the Wistar rat study at doses up to 1000 mg/kg/d

Mode of action

The mode of action of Salcaprozate Sodium is controversial, and many scientists have explored its mechanism from various angles. Theory of oral semaglutide absorption, as advocated by Novo Nordisk. The optimum once-daily tablet consists of 14 mg of semaglutide co-formulated with 300 mg of SNAC. After digestion, the tablet erodes rapidly in the stomach, resulting in the release of a highly concentrated amount of SNAC that neutralizes the pH of gastric fluid in the immediate vicinity of the tablet to inactivate pepsin. SNAC is thought to induce semaglutide monomer production and increase gastric epithelial membrane fluidity, but without affecting tight junctions, thereby allowing transcellular passage of semaglutide into systemic circulation. Part of the role of SNAC seemed to be to convert semaglutide to a more permeable monomeric form and it seems to perform this better when formulated in a stomach-specific tablet[1].SNAC forms a conjugate base at the pH of the small intestinal lumen, so it can undergo complexation via hydrophobic ion pairing (HIP) with the conjugate acid of basic amino-acid side chains in macromolecules. However, HIP cannot fully account for Eligen-mediated hydrophobization of anionic payloads including heparin and cromolyn.

References

[1] Twarog C, et al. Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10). Pharmaceutics, 2019; 11: 78.
[2] SARINJ FATTAH . Salcaprozate sodium (SNAC) enhances permeability of octreotide across isolated rat and human intestinal epithelial mucosae in Ussing chambers[J]. European Journal of Pharmaceutical Sciences, 2020, 154: Article 105509. DOI:10.1016/j.ejps.2020.105509.
[3] M GARY I RILEY Ellen A P M Cristina Castelli. Subchronic oral toxicity of salcaprozate sodium (SNAC) in Sprague-Dawley and Wistar rats.[J]. International Journal of Toxicology, 2009, 28 4: 278-293. DOI:10.1177/1091581809337737.

Salcaprozate Sodium Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Salcaprozate Sodium Suppliers

Nanjing Gold Pharmaceutical Technology Co. Ltd.
Tel
028-025-84209270 15380463325
Fax
025-84209270
Email
wgp@nanjing-pharmaceutical.com
Country
China
ProdList
67
Advantage
55
Anhui Beirui Pharmaceutical Technology Co., Ltd
Tel
0551-68665055 18130089676
Email
ahbrchem@163.com
Country
China
ProdList
18
Advantage
58
Beijing Zhongshuo Pharmaceutical Technology Development Co., Ltd
Tel
010-53679529 13801208576
Fax
010-64215766
Email
sales.2@chinazhongshuo.com
Country
China
ProdList
99
Advantage
65
Shanghai Synmedia Chemical Co., Ltd.
Tel
021-38681880 13817889927
Fax
0213390-8196
Email
sales@synmedia-chem.com
Country
China
ProdList
249
Advantage
58
Hefei TianRui Pharmaceutical Chemistry Co., Ltd.
Tel
0551-68933033 13956024211
Fax
0551-68935833
Email
trchem@163.com
Country
China
ProdList
88
Advantage
58
Chengdu Pukang Biotechnology Co., Ltd
Tel
028-82550498 19102685862
Fax
086-28-82550468
Email
sales@pu-kang.com
Country
China
ProdList
485
Advantage
58
Gansu HaoTian Chemical Technology Co., Ltd.
Tel
0943-6900332 17789447501
Fax
0931-8238232
Email
zhuanxiajiang@haotianpharm.com
Country
China
ProdList
194
Advantage
55
Xiamen Work-For-World Medcine Co., Ltd
Tel
15921822462; 15921822462
Email
keqingyong@wfwmed.com
Country
China
ProdList
122
Advantage
58
Changzhou jinhan pharmaceutical technology co., LTD
Tel
13917833665
Email
lyg@world-goldpharma.com
Country
China
ProdList
151
Advantage
58
Luofu Pharmaceutical Technology (Jiaxing) Co., Ltd
Tel
17521736884
Email
wei.wu@luofupharm.com
Country
China
ProdList
129
Advantage
58
Abydos Scientific
Tel
025-84767922 18936879710
Email
sales@abydoscientific.com
Country
China
ProdList
1009
Advantage
58
Beijing Huikang Boyuan Chemical Tech Co., Ltd
Tel
010-68862197 13810598707
Fax
010-68882204
Email
sales@huikangchem.com
Country
China
ProdList
103
Advantage
61
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2866
Advantage
58
Shanghai Hope Chem Co., Ltd.,
Tel
+21-18501659228 18501659228
Fax
sales@hope-chem.com
Email
info@hope-chem.com
Country
China
ProdList
479
Advantage
55
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4940
Advantage
60
Synthetics China Co.,Ltd
Tel
0512-65218020; 18261037325
Email
ivy.shen@pharmsyn.com
Country
China
ProdList
101
Advantage
60
Tianjin Yao Technology Development Co., Ltd.
Tel
022-18902014291 18902014291
Fax
022-66211080
Email
byswxsb01@163.com
Country
China
ProdList
98
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9458
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
Shenzhen HwaGen Pharmaceutical Co.,Ltd
Tel
18927339850
Fax
0752-5319394
Email
xiaodong.shi@rafflespt.com
Country
China
ProdList
237
Advantage
58
Nanjing Sunlida Biological Technology Co., Ltd.
Tel
025-57798810
Fax
025-57019371
Email
sales@sunlidabio.com
Country
China
ProdList
3239
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Hangzhou Read Chemical Co., Ltd
Tel
15306818081 15306818081
Fax
0571-87234255
Email
sales@hzread.com
Country
China
ProdList
61
Advantage
58
Suzhou Sino Rare Chemical Co., Ltd.
Tel
0512-62857507
Fax
+86-512-62857507
Email
sales@sinorarechem.com
Country
China
ProdList
965
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Porse Fine Chemical Co.,LTD
Tel
20-66003216 18666003216
Fax
+86-20-28069063
Email
info@porsefinechemical.com
Country
China
ProdList
2353
Advantage
62
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9648
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5873
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939 15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
16166
Advantage
55
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11578
Advantage
59
Cool Pharm, Ltd
Tel
021-60455363 18019463053
Fax
50966098
Email
sales@coolpharm.com
Country
China
ProdList
12346
Advantage
58
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9958
Advantage
58
Nova(Shanghai) Pharmaceutical Co.,Ltd
Tel
21-58226973 18917146209
Fax
+86-21-51685790
Email
Joseph@novapharmas.com
Country
China
ProdList
467
Advantage
55
DoCheman Shanghai Co., Ltd.
Tel
+86-21-31664694 157 21077413
Fax
+86-21-31664694
Email
2956364593@qq.com
Country
China
ProdList
54
Advantage
50
DebyeTec.com Inc.
Tel
18086626237 18086626237
Fax
qq:2693528373
Email
sales@debyesci.com
Country
China
ProdList
2645
Advantage
56
Shanghai PharmaPartner Co., Ltd.
Tel
19983777532
Fax
-
Email
pharmabridge@163.com
Country
China
ProdList
623
Advantage
55
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6463
Advantage
55
INTERCHEMIE NANJING PHARMATECH CO., LTD
Tel
13656237714 13656237714
Fax
0512-65852853
Email
xiaokunfu@kyyykj.com
Country
China
ProdList
295
Advantage
55
Shanghai WeiNie Chemical Technology Co., Ltd.
Tel
15902145085
Fax
-
Email
657990292@qq.com
Country
China
ProdList
668
Advantage
50
Shanghai Brain Biotechnology Co., Ltd.
Tel
13564638271
Fax
021-68948280
Email
sales@brain-biot.com
Country
China
ProdList
2987
Advantage
55
Nanjing XiLang Chemical Products Co., Ltd.
Tel
18936048580
Email
chemxilang@163.com
Country
China
ProdList
3999
Advantage
58
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5010
Advantage
55
Wuxi Asia Peptide Biotechnology Limited Company
Tel
0510-83583050 13771062561
Fax
0510-83583039
Email
willsun@peptide-search.com
Country
China
ProdList
6716
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
9996
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
TIANJIN MINXIANG BIOMEDICAL INC.
Tel
022-59596766 13313219033 18222332696
Fax
86-22-88718329
Email
jinpeng@mxpharm.com
Country
China
ProdList
98
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Hubei Hongxin Ruiyu Fine Chemical Co., Ltd.
Tel
027-65526929 15102793023
Fax
027-65526669
Email
hbhxry@foxmail.com
Country
China
ProdList
2006
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
4028
Advantage
58
Hangzhou Molcore Biopharmatech Co.,Ltd
Tel
400-711-5280 86-571-81025280
Fax
86-571-85806285
Email
sales@molcore.com
Country
China
ProdList
9967
Advantage
58
More
Less

View Lastest Price from Salcaprozate Sodium manufacturers

Hebei Longbang Technology Co., Ltd
Product
sodium,8-[(2-hydroxybenzoyl)amino]octanoate 203787-91-1
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-05-11
HebeiShuoshengImportandExportco.,Ltd
Product
Salcaprozate Sodium 203787-91-1
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-08
WUHAN FORTUNA CHEMICAL CO., LTD
Product
sodium,8-[(2-hydroxybenzoyl)amino]octanoate 203787-91-1
Price
US $0.00-0.00/g
Min. Order
1g
Purity
99.5%
Supply Ability
100kg/month
Release date
2024-06-17

203787-91-1, Salcaprozate SodiumRelated Search:


  • sodium,8-[(2-hydroxybenzoyl)amino]octanoate
  • sodium 8-(2-hydroxybenzamido)octanoate
  • Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, monosodium salt
  • SNAC
  • SNAC,sodium 8-[(2-hydroxybenzoyl)amino]octanoate
  • Salcaprozate sodium
  • Salcaprozate Sodium (SNAC)
  • SODIUM 8-(2-HYDROXYBENZAMIDO)OCTANOATE (SNAC)
  • Octanoic acid, 8-[(2-hydroxybenzoyl)amino]-, sodium salt
  • 2,5-Furandione,3-chlorodihydro-,(7R)-
  • N-[8-(2-Hydroxybenzoyl)amino]caprylic acid, disodium salt
  • Sodium 8- (2-hydroxybenzamido) caprylate
  • Sodium N-[8-(2-hydroxybenzoyl) amino ] octanoate
  • E414
  • SNAC reference standard
  • Chlorotoluron Impurity 3
  • 203787-91-1
  • 203787-19-1
  • NaC15H20NO4
  • C15H20NNaO4
  • API
  • SNAC
  • pharmaceutical
  • 203787-91-1
  • APIs