Velpatasvir
- Product Name
- Velpatasvir
- CAS No.
- 1377049-84-7
- Chemical Name
- Velpatasvir
- Synonyms
- GS 5816;CS-2204;Vipatavir;Vipataivir;Velpatasvir;MFCD28411371;Velpatasvir API;GS 5816;GS-5816;Velpatasvir(PVP);Unifiram (DM-232)
- CBNumber
- CB62743053
- Molecular Formula
- C49H54N8O8
- Formula Weight
- 883
- MOL File
- 1377049-84-7.mol
Velpatasvir Property
- Melting point:
- >170oC (dec.)
- Density
- 1.314±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- solid
- pka
- 10.75±0.46(Predicted)
- color
- Pale yellow
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
N-Bromosuccinimide Price
- Product number
- 21280
- Product name
- Velpatasvir
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21280
- Product name
- Velpatasvir
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $86
- Updated
- 2024/03/01
- Product number
- 21280
- Product name
- Velpatasvir
- Purity
- ≥98%
- Packaging
- 100mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 21280
- Product name
- Velpatasvir
- Purity
- ≥98%
- Packaging
- 250mg
- Price
- $298
- Updated
- 2024/03/01
- Product number
- V116000
- Product name
- Velpatasvir
- Packaging
- 500mg
- Price
- $470
- Updated
- 2021/12/16
Velpatasvir Chemical Properties,Usage,Production
Description
Velpatasvir (1377049-84-7) is an extremely potent pan-genotypic hepatitis C virus (HCV) NS5A inhibitor.1 It is a component of Epclusa? and Vosevi?, two clinically useful medications with 98% and 97%, respectively, cure rates for HCV.? It displayed EC50’s for GTs 1-4, 6a ranging from 6-16 pM, GT5a at 75 pM, and GT6e at 130 pM. Velpatasvir also displayed an excellent barrier to viral resistance. It has been shown in silico, that velpatasvir binds to the SARS-CoV-2 spike protein and may be a potential therapeutic.2
Uses
Velpatasvir is a NS5A inhibitor in patients with hepatitis C (HCV) infection.
Definition
ChEBI: Velpatasvir is a complex organic heteropentacyclic compound that is a hepatitis C virus nonstructural protein 5A inhibitor used in combination with sofosbuvir (under the brand name Epclusa) for treatment of patients with chronic hepatitis C of all six major genotypes. It has a role as an antiviral drug and a hepatitis C virus nonstructural protein 5A inhibitor. It is an organic heteropentacyclic compound, a N-acylpyrrolidine, a L-valine derivative, a carbamate ester, a member of imidazoles, a ring assembly and an ether.
brand name
Epclusa, Sofosvel, Velpanat (all in combination with sofosbuvir)
References
Link et al. (2019), Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi? and Epclusa?; Bioorg. Med. Chem. Lett., 29 2415 Kadioglu et al. (2020), Identification of novel compounds against three targets of SARS CoV-2 coronavirus by combined virtual screening and supervised machine learning; Comput. Biol. Med. 133 104359
Velpatasvir Preparation Products And Raw materials
Raw materials
Preparation Products
Velpatasvir Suppliers
- Tel
- +1-800-259-7612
- Fax
- +1-800-259-7612
- info@musechem.com
- Country
- United States
- ProdList
- 4660
- Advantage
- 60
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32161
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- +1 (732)236-3202
- sales@cckinase.com
- Country
- United States
- ProdList
- 2738
- Advantage
- 58
- Tel
- 86-714-3992388
- overseasales1@yongstandards.com
- Country
- United States
- ProdList
- 14332
- Advantage
- 58
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19553
- Advantage
- 58
- Tel
- +16313385890
- info@protheragen-ing.com
- Country
- United States
- ProdList
- 3868
- Advantage
- 58
- Tel
- +1-+1(833)-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57505
- Advantage
- 58
- Tel
- support@targetmol.com
- Country
- United States
- ProdList
- 38631
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@focusbiomolecules.com
- Country
- United States
- ProdList
- 1284
- Advantage
- 58
- Tel
- --
- Fax
- --
- cayman@caymanchem.com
- Country
- United States
- ProdList
- 6213
- Advantage
- 81
- Tel
- --
- Fax
- --
- chemicals@usbio.net
- Country
- United States
- ProdList
- 6214
- Advantage
- 80
View Lastest Price from Velpatasvir manufacturers
- Product
- Velpatasvir 1377049-84-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 98%-102%
- Supply Ability
- 10 KGS
- Release date
- 2021-06-16
- Product
- Velpatasvir(PVP) 1377049-84-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 98% HPLC
- Supply Ability
- 100kg
- Release date
- 2023-08-14
- Product
- Velpatasvir 1377049-84-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- More Than 99%
- Supply Ability
- 100kg/Month
- Release date
- 2024-09-04