Velpatasvir intermediate

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Velpatasvir intermediate

Product Name: Velpatasvir intermediate
CAS No.: 1378391-45-7
Chemical Name: Velpatasvir intermediate
Synonyms: Velpatasvir R Isomer;intermediate for Velpatasvir;Boc Velpatasvir R Isomer (Imidazole);Velpatasvir S,S Isomer (Imidazole) Boc;Velpatasvir intermediate ISO 9001：2015 REACH;Tert-Butyl(2S,4S)-2-(4-(2-((2S,5S)-1-((methoxycarbonyl);tert-butyl (2S,4S)-2-(5-(2-((2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methyl;tert-butyl(2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,11-;(2S,4S)-2-[5-[1,11-Dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-meth;(2S,4S)-2-[5-[1,11-Dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4
CBNumber: CB62748922
Molecular Formula: C44H53N7O7
Formula Weight: 791.93
MOL File: 1378391-45-7.mol

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Velpatasvir intermediate Property

Boiling point:: 1045.8±65.0 °C(Predicted)
Density: 1.275±0.06 g/cm3(Predicted)
pka: 11.22±0.46(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B806955
Product name: (2S,4S)-tert-Butyl2-(5-(2-((2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidin-2-yl)-1,11-dihydroisochromeno[4'',3'':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate
Packaging: 250mg
Price: $50
Updated: 2021/12/16

TRC

Product number: B806955
Product name: (2S,4S)-tert-Butyl2-(5-(2-((2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidin-2-yl)-1,11-dihydroisochromeno[4'',3'':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate
Packaging: 1g
Price: $110
Updated: 2021/12/16

TRC

Product number: B806955
Product name: (2S,4S)-tert-Butyl2-(5-(2-((2S,5S)-1-((S)-2-((Methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidin-2-yl)-1,11-dihydroisochromeno[4'',3'':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate
Packaging: 5g
Price: $440
Updated: 2021/12/16

Crysdot

Product number: CD11269137
Product name: (2S,4S)-tert-Butyl2-(5-(2-((2S,5S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidin-2-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate
Purity: 97%
Packaging: 10g
Price: $650
Updated: 2021/12/16

Alichem

Product number: 1378391457
Product name: (2S,4S)-tert-Butyl2-(5-(2-((2S,5S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-5-methylpyrrolidin-2-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate
Packaging: 10g
Price: $663
Updated: 2021/12/16

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Velpatasvir intermediate Chemical Properties,Usage,Production

Uses

Velpatasvir S, R Isomer (Imidazole) BOC acts as a reagent in the preparation of peptide analog as antiviral agents, preparation of condensed pentacyclic imidazole derivatives as antiviral compounds.

Uses

Intermediates of Velpatasvir can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly for the synthesis of API Velpatasvir.

Synthesis

tot-Butyl (2S,4S)-2-[5-(2-{(2S,5S)-l-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}- l,ll-dihydroisochromeno[4',3':6,7]naphtho[l,2-d]imidazol-9-yl)-lH-imidazol-2-yl]-4- (methoxymethyl)pyrrolidine-l-carboxylate tert-Butyl (2S,4S)-2-[5-(2- {(2S,5S)-l-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2- yl} -l ,4,5,l l-tetrahydroisochromeno[4',3':6,7]naphtho[l,2-d]imidazol-9-yl)-lH-imidazol-2-yl]-4- (methoxymethyl)pyrrolidine-l-carboxylate (8.33 g, 1.049 mmol) was suspended in DCM and activated Mn02 (55.0 g, 630 mmol) was added in a single portion. After 13 h, MeOH (200 mL) was added and the slurry was filtered over celite. The filter cake was washed with MeOH (600 mL) and the filtrate was concentrated under reduced pressure. The crude material was purified by silica column chromatography (0% to 45% MeOH/EtOAc) to afford tert-butyl (2S,4S)-2-[5-(2- {(2S,5S)-l-[N- (methoxycarbonyl)-L-valyl] -5 -methylpyrrolidin-2-yl} -1,11- dihydroisochromeno[4',3':6,7]naphtho[l,2-d]imidazol-9-yl)-lH-imidazol-2-yl]-4- (methoxymethyl)pyrrolidine-l-carboxylate (4.85 g, 58%).

Velpatasvir intermediate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Velpatasvir intermediate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Velpatasvir Intermediate 1378391-45-7
Price: US $0.00-0.00/KG
Min. Order: 10g
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2019-12-25

Shaanxi Dideu Medichem Co. Ltd

Product: Velpatasvir Intermediate 1378391-45-7
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 100 tons
Release date: 2020-01-14

Career Henan Chemical Co

Product: Velpatasvir intermediate 1378391-45-7
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

1378391-45-7, Velpatasvir intermediateRelated Search:

9-Bromo-3-(2-Bromo Acetyl)-10,11-Dihydro-5H-dibenzo(c,g) Chromen-8(9H)-one (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER Velpatasvir Velpatasvir intermediate Velpatasvir intermediate (R)-2-(methoxycarbonylamino)-2-phenylacetic acid Velpatasvir Co Povidone Velpatasvir intermediate (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid BOC-L-PYROGLUTAMIC ACID BENZYL ESTER Velpatasvir-A12

(2S,4S)-2-[5-[1,11-Dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl e

tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate (N-2 step)

intermediate for Velpatasvir

(2S,4S)-TERT-BUTYL 2-(5-(2-((2S,5S)-1-((S)-2-((METHOXYCARBONYL)AMINO)-3-METHYLBUTANOYL)-5-METHYLPYRROLIDIN-2-YL)-1,11-DIHYDROISOCHROMENO[4',3':6,7]NAPHTHO[1,2-D]IMIDAZOL-9-YL)-1H-IMIDAZOL-2-YL)-4-(METHOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE

(2S,4S)-2-[5-[1,11-Dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4

tert-butyl (2S,4S)-2-(5-(2-((2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methyl

Tert-Butyl(2S,4S)-2-(4-(2-((2S,5S)-1-((methoxy carbonyl)-L-valyl)-5-methyl pyrrolidin-2-yl)-1,11-dihydro isochro-meno[4,3:6,7]Naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidine-1-carboxylate

Tert-Butyl(2S,4S)-2-(4-(2-((2S,5S)-1-((methoxycarbonyl)

tert-butyl(2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrro

tert-butyl (2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl]-4-(methoxymethyl)pyrrolidine-1-carboxylate (or) Oxidized compound

(2S,4S)-2-[5-[1,11-Dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-meth

1-Pyrrolidinecarboxylic acid, 2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-, 1,1-dimethylethyl ester, (2S,4S)-

Velpatasvir intermediate ISO 9001：2015 REACH

tert-butyl(2S,4S)-2-[5-(2-{(2S,5S)-1-[N-(methoxycarbonyl)-L-valyl]-5-methylpyrrolidin-2-yl}-1,11-

Velpatasvir R Isomer

Boc Velpatasvir R Isomer (Imidazole)

Velpatasvir S,S Isomer (Imidazole) Boc

Tert-butyl (2S,4S)-2-(5-(2-((2S,5S)-1-((methoxycarbonyl)-L-valyl-5-methylpyrrrolidin-2-yl)-1,11-dihydroisocgromeno[4’,3’:6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidin-1-carboxylate

tert - buty ](2S,4S)-2-(5-(2-((2S,5S)-1-(( methoxycarbonyl )- L - valyl )-5- methylpyrrolidin -2- yl )-1,11- dihydroisochromeno [4,3':6,7] naphtho [1,2- d ] imidazol -9- yl )-1H- imidazol -2- yl )-4-( methoxymethyl ) pyrrolidin e -1- carboxylate

2S, 4S) -2- [5- [1,11-dihydro-2- [(2S, 5S) -1- [(2S) -2- [(methoxycarbonyl) amino] -3-methyl-1-oxobutyl] -5-methyl-2-pyrrolidine] [2] benzopyrano [4 ', 3': 6,7] naphtho [1,2-D] imidazole-9-yl] -1H-imidazo-2-yl] -4- (methoxymethyl) -1-pyrrolidine carboxylate tert butyl ester

(2S,4S)-2-[5-[1,11-Dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzoChemicalbookpyrano[4',3':6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinecarboxylicacid1,1-dimethylethyle

(2S,4S)-TERT-BUTYL2-(5-(2-((2S,5S)-1-((S)-2-((METHOXYCARBONYL)AMINO)-3-METHYLBUTANOYL)-5-METHYLPYRROLIDIN-2-YL)-1,11-DIHYDROISOCHROMENO[4',3':6,7]NAPHTHO[1,2-D]IMIDAZOL-9-YL)-1H-IMIDAZOL-2-YL)-4-(METHOXYMETHYL)PYRROLIDINE-1-CARBOXYLATE

1378391-45-7