ChemicalBook > CAS DataBase List > Ceftezole

Ceftezole

Product Name
Ceftezole
CAS No.
26973-24-0
Chemical Name
Ceftezole
Synonyms
CTZ;CG-B 3Q;FR 10123;Celoslin;ceftezol;CEFTEZOLE;CEPHTEZOL;Ceftazole;NSC 102805;Ceftezole Acid
CBNumber
CB6277787
Molecular Formula
C13H12N8O4S3
Formula Weight
440.48
MOL File
26973-24-0.mol
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Ceftezole Property

Melting point:
155°C (dec.)
Density 
2.09
storage temp. 
Store at -20°C
solubility 
DMSO: 88 mg/mL (199.78 mM);;
pka
2.60±0.50(Predicted)
λmax
273nm(Phosphate buffer sol.)(lit.)
Merck 
14,1948
CAS DataBase Reference
26973-24-0(CAS DataBase Reference)
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Safety

Hazard Codes 
T+,N
Risk Statements 
21/22-26-50/53
Safety Statements 
28-36/37-45-61
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
716707
Product name
Cadmium zinc telluride
Purity
99.9999% trace metals basis
Packaging
5g
Price
$146
Updated
2023/01/07
TRC
Product number
C244315
Product name
Ceftezole
Packaging
10g
Price
$85
Updated
2021/12/16
AK Scientific
Product number
J11705
Product name
Ceftezole
Packaging
25mg
Price
$38
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC41103
Product name
Ceftezole
Packaging
2g
Price
$50
Updated
2021/12/16
Chem-Impex
Product number
38389
Product name
Ceftezole,98%(HPLC)
Purity
98%(HPLC)
Packaging
5G
Price
$72.8
Updated
2021/12/16
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Ceftezole Chemical Properties,Usage,Production

Originator

Ceftezole,Arocor Holdings Inc.

Uses

Ceftezole is a β-lactam, cephem antibiotic. It also exhibits potent α-glucosidase inhibitory activity and antidiabetic effect in streptozotocin-induced mouse.

Uses

A direct bandgap semiconductor, it is used in a variety of applications, including radiation detectors, photorefractive gratings, electro-optic modulators, solar cells, and terahertz generation and detection. The band gap varies from approximately 1.4 to 2.2 eV, depending on composition.

Definition

ChEBI: Ceftezole is a first-generation cephalosporin antibiotic having (1,3,4-thiadiazol-2-ylsulfanyl)methyl and [2-(1H-tetrazol-1-yl)acetamido side groups located at positions 3 and 7 respectively. It is a cephalosporin and a member of thiadiazoles.

Manufacturing Process

To a solution of 1 equivalent (eq.) of 1H-tetrazole-1-acetic acid and 1 eq. of triethylamine in 20 ml of tetrahydrofuran cooled to -20°C was added 1 eq. of pivaloyl chloride. After thirty-minute stirring of the mixture 20 ml of a chloroform solution containing 1 eq. of and 1 eq. of triethylamine was poured into the solution cooled at -10°C during a period of 30 minutes. The resulting mixed solution was stirred for 30 minutes at the same temperature, for 1 hour in an ice-water mixture and for 3 hours at room temperature. Removal of a solvent from the reaction mixture afforded an oily residue, which was dissolved into 15 ml of 10% sodium bicarbonate aqueous solution. The resulting aqueous layer was adjusted to pH 1.0-2.0 with 10% hydrochloric acid, washed with ether and extracted with ethyl acetate. The extract was washed with water, dried over sodium sulfate and concentrated under reduced pressure leaving a residue which was triturated with ethyl acetate to obtain 3- acetoxymethyl-8-oxo-7-(2-tetrazol-1-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid.
A solution of 1 eq. of sodium salt of 3-acetoxymethyl-8-oxo-7-(2-tetrazol-1- acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (it may be prepared with equivalent of sodium bicarbonate and above named acid) and 1 eq. of [1.3.4]-thiadiazole-2-thiol in 20 ml of phosphate buffer (pH 6.4) was stirred for 5.5 hours at 60°C. The reaction mixture was adjusted to pH 2.0 with 5% hydrochloric acid and treated with ethyl acetate to form a title compound - ceftezole.

Therapeutic Function

Antibiotic

General Description

Cadmium zinc telluride (Cd1-xZnxTe or CZT) can detect nuclear radiation hence, CZT with Zn concentrations between 0.1-0.2 may be used in the making of radiation detectors of X-ray and gamma-ray spectrometers.

Ceftezole Preparation Products And Raw materials

Raw materials

Preparation Products

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Ceftezole Suppliers

Americas 1 China 116 Europe 1 Germany 2 India 10 Japan 1 South Korea 1 United Kingdom 4 United States 16 Global 152
BOC Sciences
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1-631-485-4226; 16314854226
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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Protheragen-ING
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+16313385890
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Aladdin Scientific
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+1-+1(833)-552-7181
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sales@aladdinsci.com
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Waterstone Technology, LLC
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OChem Incorporation
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View Lastest Price from Ceftezole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Ceftezole 26973-24-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ceftezole 26973-24-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09
Shaanxi Dideu Medichem Co. Ltd
Product
Ceftezole 26973-24-0
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
300 MT
Release date
2020-05-23

26973-24-0, CeftezoleRelated Search:

Thioacetamide 2-Mercapto-5-methyl-1,3,4-thiadiazole 2,1,3-Benzothiadiazole Betaine Sodium thiosulfate ALTRENOGEST Thioacetic acid Glycine 2-Thiobarbituric acid Cefditoren pivoxil Cefazedone Cefoxitin CEFTEZOLE SODIUM Cefazolin sodium salt Cefazolin TETRAZOLE-1-ACETIC ACID CEFAZOLIN CEFTEZOLE 1H-TETRAZOLE Ceftezole Sodium Sterile

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  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-, (6R-trans)-
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 8-oxo-7-[2-(1H-tetrazol-1-yl)acetamido]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]- (8CI)
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  • (6r,7r)-8-oxo-7-[(1h-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
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  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-, (6R,7R)-
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  • NSC 102805
  • (6R,7R)-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-3-(1,3,4-thiadiazol-2-ylsulfanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 26973-24-0
  • C13H12N8O4S3