2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-

Product Name: 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-
CAS No.: 21416-87-5
Chemical Name: 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-
Synonyms: ICRF;Razoxin;ICRF-159;Razoxane;ICRF-187;Zinecard;ICI-59118;Eucardion;NSC-169780;NSC-129943
CBNumber: CB6281980
Molecular Formula: C11H16N4O4
Formula Weight: 268.27
MOL File: 21416-87-5.mol

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2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Property

Melting point:: 233.5°C
Boiling point:: 411.43°C (rough estimate)
Density: 1.2576 (rough estimate)
refractive index: 1.6081 (estimate)
storage temp.: Refrigerator
solubility: DMSO (Slightly)
form: Solid
color: White

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Hazard and Precautionary Statements (GHS)

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2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Chemical Properties,Usage,Production

Chemical Properties

White or almost white or light beige crystal or crystalline powder, odorless, slightly bitter taste. Soluble in hot water, insoluble in water or ethanol. Melting point 233-234℃(decomposition), melting point 237-239℃. (+)-configuration (Dexrazoxane): [24584-09-6]. Crystallized from aqueous methanol-ether, melting point 193 °C. [α]D+11.35° (C=5, dimethylformamide). Solubility (mg/ml): 10-12 (water), 35-43 (0.1 mol/L hydrochloric acid), 25-34 (0.1 mol/L sodium hydroxide), 6.7-10 (10% ethanol), 1 (methanol), 7.1-10 [water-dimethylformamide (1:1)], 9.7-14.5 [0.1 mol/L citrate buffer (Ph 4) ], 8.7 to 13 [0.1 mol/L boric acid buffer (Ph 9)].

Uses

Razoxane is an inhibitor of Topo II.

Definition

ChEBI: Razoxane is a N-alkylpiperazine.

Safety Profile

Suspected carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by intraperitoneal route. Experimental teratogenic and reproductive effects. Human systemic effects by ingestion: nausea, thrombocytopenia, leukopenia. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Preparation Products And Raw materials

Raw materials

1,2-Diaminopropane-N,N,N',N'-tetraacetic acid Formamide

Preparation Products

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2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Suppliers

China 11 Europe 2 Germany 1 India 2 United States 6 Global 22

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: 029-029-81024372 17792795018
Fax: 029-88380327
Email: 1027@dideu.com
Country: China
ProdList: 10003
Advantage: 58

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View Lastest Price from 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- manufacturers

Dideu Industries Group Limited

Product: 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- 21416-87-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2021-07-02

21416-87-5, 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-Related Search:

Dexrazoxane Pemetrexed Disodium (S)-(-)-1,2-Diaminopropane dihydrochloride Dexrazoxane hydrochloride 4-(2-AMINO-ETHYL)-PIPERAZIN-2-ONE 1,1'-ethylenedipiperazine 4,4-(2,3-BUTANEDIYL)-BIS(2,6-PIPERAZINEDIONE) ETHYLIMINUM 4-methylpiperazine-2,6-dione 1-(2-DIETHYLAMINOETHYL)PIPERAZINE 2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- Piperazine-2,6-dione

2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS-

(±)-1，2-Bis(3，5-diox-opiperazinyl)propane

Razoxane

ICRF

ICRF-159

Eucardion

ICI-59118

ICRF-187

NSC-129943

NSC-169780

PropylenediamineTetraacetylimide

Razoxin

Zinecard

(±)-4,4'-(1-Methyl-1,2-ethanediyl)bis(2,6-piperazinedione)

NCI-C-01627

rac-ICRF-159

(+-)-(3,5,3',5'-Tetraoxo)-1,2-dipiperazinopropane

.+-.-(3,5,3',5'-Tetraoxo)-1,2-dipiperazinopropane

2,6-Piperazinedione, 4,4'-propylenedi-

2,6-Piperazinedione, 4,4'-propylenedi-, (.+-.)-

2,6-Piperazinedione, 4,4'-propylenedi-, (+-)-

2,6-PIPERAZINEDIONE, 4,4'-(1-METHYL-1,2-ETHANEDIYL)BIS- USP/EP/BP

21416-87-5