CHLAMYDOCIN
- Product Name
- CHLAMYDOCIN
- CAS No.
- 53342-16-8
- Chemical Name
- CHLAMYDOCIN
- Synonyms
- SL-3440;CHLAMYDOCIN;Antibiotic SL-3440;2-Methylcyclo[Ala-L-Phe-D-Pro-6-[(S)-2-oxo-2-oxiranylethyl]-L-Nle-];Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl];Cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(aS,2S)-a-amino-h-oxo-2-oxiraneoctanoyl]
- CBNumber
- CB6283843
- Molecular Formula
- C28H38N4O6
- Formula Weight
- 526.63
- MOL File
- 53342-16-8.mol
CHLAMYDOCIN Property
- Boiling point:
- 861.8±65.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble; Ethanol: soluble; Methanol: soluble
- form
- A solid
- pka
- 13.36±0.70(Predicted)
Safety
- HS Code
- 29419000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- 28468
- Product name
- Chlamydocin
- Packaging
- 1mg
- Price
- $396
- Updated
- 2024/03/01
- Product number
- C292200
- Product name
- Chlamydocin
- Packaging
- 10mg
- Price
- $1320
- Updated
- 2021/12/16
CHLAMYDOCIN Chemical Properties,Usage,Production
Description
Chlamydocin is a histone deacetylase (HDAC) inhibitor that was originally isolated from D. chlamydosporia and has anticancer properties. It is selective for HDAC1 over HDAC6 (IC50 = 0.15 and 1,100 nM, respectively). Chlamydocin increases acetylation of histone H3 and histone H4 in A2780 cells when used at concentrations ranging from 1 to 1,000 nM. It inhibits growth of A2780, Malme-3M, MCF-7, HT-29, and HeLa cancer cells (IC50s = 0.36, 45, 5.3, 4.3, and 14 nM, respectively). Chlamydocin increases lifespan by 10% in a P185 mouse allograft model when administered at doses ranging from 20 to 160 mg/kg.
Uses
Chlamydocin is a cyclic tetrapeptide and an irreversible histone deacetylase (HDAC) inhibitor.
CHLAMYDOCIN Preparation Products And Raw materials
Raw materials
Preparation Products
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