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1-(3-CHLOROPROPYL)-PYRROLIDINE

Product Name
1-(3-CHLOROPROPYL)-PYRROLIDINE
CAS No.
39743-20-9
Chemical Name
1-(3-CHLOROPROPYL)-PYRROLIDINE
Synonyms
Albb-007086;N-CHLOROPROPYL PYRROLIDINE;1-(3-CHLOROPROPYL)-PYRROLIDINE;Pyrrolidine,1-(3-chloropropyl)-;(3-Chloropropyl)pyrrolidine, HCl
CBNumber
CB6283924
Molecular Formula
C7H14ClN
Formula Weight
147.65
MOL File
39743-20-9.mol
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1-(3-CHLOROPROPYL)-PYRROLIDINE Property

Boiling point:
88-89 °C(Press: 22 Torr)
Density 
1.016±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
pka
10.10±0.20(Predicted)
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C7H14ClN/c8-4-3-7-9-5-1-2-6-9/h1-7H2
InChIKey
SPRTXTPFQKHSBG-UHFFFAOYSA-N
SMILES
N1(CCCCl)CCCC1
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Safety

HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C214565
Product name
1-(3-chloropropyl)pyrrolidine
Packaging
50mg
Price
$45
Updated
2021/12/16
TRC
Product number
C214565
Product name
1-(3-chloropropyl)pyrrolidine
Packaging
500mg
Price
$285
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC117862
Product name
1-(3-Chloropropyl)pyrrolidine hydrochloride
Packaging
50mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC117862
Product name
1-(3-Chloropropyl)pyrrolidine hydrochloride
Packaging
100mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC117862
Product name
1-(3-Chloropropyl)pyrrolidine hydrochloride
Packaging
250mg
Price
$160
Updated
2021/12/16
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1-(3-CHLOROPROPYL)-PYRROLIDINE Chemical Properties,Usage,Production

Synthesis

123-75-1

109-70-6

39743-20-9

Example 4 Synthesis of 1-(3-chloropropyl)pyrrolidine At 0°C, 186 g (1.18 mol) of 1-bromo-3-chloropropane was dissolved in 200 ml of ether and 2 equivalents of pyrrolidine were slowly added. After addition, the reaction mixture was gradually warmed to room temperature and stirred overnight. Upon completion of the reaction, the resulting white solid was removed by filtration. Ice-cold 10% hydrochloric acid solution was added to the filtrate and the ether layer was discarded after partitioning. The aqueous phase was alkalized with ice-cold 20% sodium hydroxide solution and subsequently extracted with ether. The organic phases were combined and dried over anhydrous sodium sulfate. The ether was evaporated under reduced pressure and the residue was distilled under reduced pressure at 95 °C/30 mmHg to give 91 g of the target product 1-(3-chloropropyl)pyrrolidine as a pale yellow liquid in 53% yield.

References

[1] Pharmazie, 1980, vol. 35, # 2, p. 69 - 72
[2] Patent: EP1593679, 2005, A1. Location in patent: Page/Page column 27
[3] Patent: US2005/245524, 2005, A1. Location in patent: Page/Page column 27
[4] European Journal of Medicinal Chemistry, 2014, vol. 89, p. 198 - 206
[5] Journal of the American Chemical Society, 1955, vol. 77, p. 2855,2857

1-(3-CHLOROPROPYL)-PYRROLIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-CHLOROPROPYL)-PYRROLIDINE Suppliers

China 76 Germany 1 India 2 Ireland 1 Ukraine 2 United Kingdom 3 United States 13 Global 98
Krain Pharmaceutical Technology CO.,Ltd
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39743-20-9, 1-(3-CHLOROPROPYL)-PYRROLIDINERelated Search:

(3-Chloropropyl)pyrrolidine Hydrochloride,1-(3-CHLOROPROPYL)-PYRROLIDINE HYDROCHLORIDE 1-(3-CHLOROPROPYL)-PYRROLIDINE 1-((S)-3-CHLORO 2-METHYLPROPIONYL)-L-PROLINE 1-(3-chloropropanoyl)pyrrolidine (R)-1-(3-chloropropyl)pyrrolidin-3-ol N-(2-Chloropropyl)pyrrolidine HCl N-(3-Chloropropyl)pyrrolidine maleate salt 1-(3-Chloropropyl)pyrrolidine maleate 1-(2-Chloropropyl)pyrrolidine 1-(3-chloropropyl)pyrrolidin-3-ol 1-(3-chloropropyl)pyrrolidin-2-one 5-CHLORO-6-((2-IMINOPYRROLIDIN-1-YL)METHYL)-5,6-DIHYDROPYRIMIDIN-4(3H)-ONE HYDROCHLORIDE 3,5-DIOXO-10-OXA-4-AZATRICYCLO[5.2.1.0(2,6)]DEC-8-EN-4-YL 3-CHLORO-2,2-DIMETHYLPROPANOATE 1-(3-CHLORO-3-PHENYLPROPYL)PYRROLIDINE HYDROCHLORIDE 1-(3-chloropropyl)pyrrolidine-2,5-dione (S)-1-(3-chloropropyl)pyrrolidin-3-ol 1-[(2,2-DICHLOROCYCLOPROPYL)METHYL]PYRROLIDINE

  • N-CHLOROPROPYL PYRROLIDINE
  • Pyrrolidine,1-(3-chloropropyl)-
  • Albb-007086
  • (3-Chloropropyl)pyrrolidine, HCl
  • 1-(3-CHLOROPROPYL)-PYRROLIDINE
  • 39743-20-9