ChemicalBook > CAS DataBase List > Proflavine hemisulfate

Proflavine hemisulfate

Product Name: Proflavine hemisulfate
CAS No.: 1811-28-5
Chemical Name: Proflavine hemisulfate
Synonyms: PROFLAVINE HEMISULPHATE;PROFLAVINE HEMISULFATE SALT;3,6-DIAMINOACRIDINIUM MONOHYDROGEN SULFATE;PROFLAVINE SULFATE;PROFLAVINE HEMISULFATE;Proflavin hemisulphate;PROFLAVINE HEMISULFATE;bis(acridine-3,6-diamine);3,6-DIAMINOACRIDINE SULFATE;2 8-DIAMINOACRIDINE SULFATE
CBNumber: CB6285832
Molecular Formula: C13H13N3O4S
Formula Weight: 307.32
MOL File: 1811-28-5.mol

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Proflavine hemisulfate Property

storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly, Heated), Water (Slightly, Heated)
form: powder
color: Orange to Amber to Dark red
PH: pH (1g/l, 25℃) : 4.0～8.0
Water Solubility: H2O: 10mg/mL
BRN: 3921806
Stability:: Hygroscopic
EPA Substance Registry System: 3,6-Acridinediamine, sulfate (2:1) (1811-28-5)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: AR9065100
F: 3-8-10-23
HS Code: 2918.19.9000
Toxicity: mouse,LD50,subcutaneous,200mg/kg (200mg/kg),Quarterly Journal of Pharmacy & Pharmacology. Vol. 10, Pg. 649, 1937.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P2508
Product name: Proflavine hemisulfate salt hydrate
Purity: powder
Packaging: 10g
Price: $71.91
Updated: 2025/07/31

Sigma-Aldrich

Product number: P2508
Product name: Proflavine hemisulfate salt hydrate
Purity: powder
Packaging: 1g
Price: $18.8
Updated: 2023/06/20

TCI Chemical

Product number: D0073
Product name: Proflavine Hemisulfate Hydrate
Purity: >97.0%(N)
Packaging: 5g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: D0073
Product name: Proflavine Hemisulfate Hydrate
Purity: >97.0%(N)
Packaging: 25g
Price: $117
Updated: 2025/07/31

Sigma-Aldrich

Product number: P2508
Product name: Proflavine hemisulfate salt hydrate
Purity: powder
Packaging: 25g
Price: $165
Updated: 2025/07/31

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Proflavine hemisulfate Chemical Properties,Usage,Production

Description

Proflavine Hemisulfate, the hemisulfate form of proflavin, is an acridine-derived fluorescent contrast agent and disinfectant used for cell imaging and antiseptic purposes. Following topical application, proflavin diffuses into cells and intercalates into DNA, leading to its accumulation in and staining of the nucleus. This allows visualization of the nucleus during fluorescence imaging. Such capability enables nuclear morphometry and facilitates the identification of cancer cells. Additionally, proflavin sulfate exerts antimicrobial effects through binding to bacterial DNA, which disrupts DNA synthesis and inhibits bacterial cell growth.

Chemical Properties

orange to brown crystalline powder

Uses

An Acridine derivative with limited antifungal activity

Uses

Proflavine Hemisulfate is used in preparation of Adenine and Adenine nucleotides via photochemical demethylation of methyladenines.

in vivo

The concentrations of Proflavine (20 mg/kg) in whole blood after intravenous injection decreased rapidly at the beginning and remained stable from around 30 min after dosing^[3].

Animal Model:	Adult male Sprague Dawley rats (weighing approximately 200 g)^[3]
Dosage:	20 mg/kg (Pharmacokinetic Analysis)
Administration:	Intravenous injection; 2, 4, 5, 10, 15, 20, 25, and 30 min after dosing
Result:	Concentration decreased rapidly from whole blood in the first 5 min after dosing, followed by a slower decrease.

Purification Methods

An aqueous solution, after treatment with charcoal, is concentrated, chilled overnight, filtered and the precipitate is rinsed with a little diethyl ether. The precipitate is dried in air, then overnight in a vacuum oven at 70o. [Beilstein 22 I 650, 22/11 V 323.]

Proflavine hemisulfate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Proflavine hemisulfate manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: Acridine-3,6-diamine hemisulfate 1811-28-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-09-18

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: Proflavine hemisulfate 1811-28-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-09-18

1811-28-5, Proflavine hemisulfateRelated Search:

3,6-DIAMINOACRIDINE HYDROCHLORIDE CI NO 46040 ACRIDINE ORANGE ACRIDINE ORANGE ACRIFLAVINE Basic Orange 14 NONYL ACRIDINE ORANGE CI 46025 PROFLAVINE Proflavine hemisulfate Acriflavine hydrochloride CORIPHOSPHINE O 2,8-BIS(DIMETHYLAMINO)-10-DODECYL-ACRIDINIUM BROMIDE PROFLAVINE HEMISULFATE,PROFLAVINE HEMISULFATE N-HYDRATE BENZOFLAVIN 3,6-DIAMINO-10-METHYLACRIDINIUM CHLORIDE POLY(PYROMELLITIC DIAHYDRIDE-ALT-PROFLAVINE HEMISULFATE) POLY(3,3',4,4'-BENZOPHENONETETRACARBOXYLIC DIANHYDRIDE-ALT-PROFLAVINE HEMISULFATE)

PROFLAVINE HEMISULFATE SALT HYDRATE(RG)

Proflavine hemisulfate salt dihydrate

3,6-acridinediamine,sulfate(2:1)

3,6-diamino-acridinsulfate(2:1)

PROFLAVINE SULFATE

PROFLAVINE HEMISULFATE

PROFLAVINE HEMISULFATE SALT

PROFLAVINE HEMISULPHATE

3,6-DIAMINOACRIDINE SULFATE

3,6-DIAMINOACRIDINIUM MONOHYDROGEN SULFATE

3,6-DIAMINOACRIDINE HEMISULFATE

3,6-DIAMINOACRIDINE HEMISULFATE SALT

3,6-DIAMINOACRIDINE HEMISULPHATE

2 8-DIAMINOACRIDINE SULFATE

3,6-Diaminoacridine hemisulfate, hydrate,98%

PROFLAVINE HEMISULFATE DIHYDRATE, FOR FL UORESCENCE

ProflavinrHemisulfateDihydrate(3,6-Diaminoacridi

proflavine hemisulfate salt hydrate

PROFLAVINE HEMISULFATE HYDRATE

Proflavine hydrate hemisulfate salt

3,6-Diaminoacridine monohydrochloride, Proflavine dihydrate hemisulfate salt

6-Diaminoacridine hemisulfate

Proflavine Hemisulfate Hydrate&gt

Proflavin hemisulphate

PROFLAVINE HEMISULPHATE DIHYDRATE Extra Pure

bis(acridine-3,6-diamine)

inhibit,channel,gated,Potassium Channel,blood,Proflavine Hemisulfate,KcsA,rectifier,Whole,inward,G protein,Autophagy,Inhibitor,Bacterial

PROFLAVINE HEMISULFATE

1811-28-5

2C13H11N3H2SO4

C13H11N305H2SO4xH2O

C26H24N6O4S

C13H11N3H2SO4

C13H11N305H2O4SH2O

C13H11N305H2SO4

C26H22N6H2SO4xH2O

C13H11N312H2O4S

2C13H11N3H2OH2O4S

Detection

Fluorescent Probes, Labels, Particles and Stains

Biochemicals and Reagents

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AMINE

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Biochemistry

Vitamin Derivatives

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