ChemicalBook > CAS DataBase List > CYCLOPENTOLATE HYDROCHLORIDE

CYCLOPENTOLATE HYDROCHLORIDE

Product Name: CYCLOPENTOLATE HYDROCHLORIDE
CAS No.: 5870-29-1
Chemical Name: CYCLOPENTOLATE HYDROCHLORIDE
Synonyms: Alnide;cyclogyl;Zyklolat;Mydplegic;5-Hydroxy-1;Ak-Pentolate;Cyclopentolate HCl USP;Cyclogyl hydrochloride;LABOTEST-BB LT00244824;CYCLOPENTOLATE HYDROCHLORIDE
CBNumber: CB6287038
Molecular Formula: C17H26ClNO3
Formula Weight: 327.85
MOL File: 5870-29-1.mol

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CYCLOPENTOLATE HYDROCHLORIDE Property

Melting point:: 137-141°
storage temp.: Inert atmosphere,Room Temperature
solubility: Very soluble in water, freely soluble in ethanol (96 per cent). It shows polymorphism (5.9).
form: Solid
color: White to Off-White
InChI: InChI=1S/C17H25NO3.ClH/c1-18(2)12-13-21-16(19)15(14-8-4-3-5-9-14)17(20)10-6-7-11-17;/h3-5,8-9,15,20H,6-7,10-13H2,1-2H3;1H
InChIKey: RHKZVMUBMXGOLL-UHFFFAOYSA-N
SMILES: C1(O)(CCCC1)C(C(=O)OCCN(C)C)C1C=CC=CC=1.Cl

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Safety

WGK Germany: 2
RTECS: GY2450000
HS Code: 2922190900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0001088
Product name: Cyclopentolate for system suitability
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 20 mg
Price: $225
Updated: 2025/07/31

Sigma-Aldrich

Product number: C3245000
Product name: Cyclopentolate hydrochloride
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 80 mg
Price: $159
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1156000
Product name: Cyclopentolate hydrochloride
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 300mg
Price: $419
Updated: 2025/07/31

Cayman Chemical

Product number: 23944
Product name: Cyclopentolate (hydrochloride)
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 23944
Product name: Cyclopentolate (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $78
Updated: 2024/03/01

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CYCLOPENTOLATE HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Cyclopentolate is an antagonist of muscarinic acetylcholine receptors (K_is = 1.62, 27.5, and 2.63 nM for M₁, M₂, and M₃ receptors, respectively). It inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (K_bs = 7.9, 15.8, and 12.5 nM, respectively). Formulations containing cyclopentolate have been used to induce pupil dilation and to prevent the eye from accommodating for near vision.

Chemical Properties

White Solid

Originator

Cyclogyl,Schieffelin,US,1953

Uses

Mydriatic;Cholinergic receptor antagonist

Uses

antiviral

Uses

antitussive

Uses

A mydriatic

Definition

ChEBI: Cyclopentolate hydrochloride is the hydrochloride salt of cyclopentolate. It is used to produce mydriasis (excessive dilation of the pupil) and cycloplegia (paralysis of the ciliary muscle of the eye) for opthalmic diagnostic procedures. It acts more quickly than atropine and has a shorter duration of action. It has a role as a mydriatic agent, a parasympatholytic, a diagnostic agent and a muscarinic antagonist. It contains a cyclopentolate.

Manufacturing Process

To a well stirred suspension of 9 g of sodium phenyl acetate and 2.4 g of magnesium turnings in 25 cc of anhydrous ether, a solution of 9.4 cc of isopropyl bromide in 50 cc of anhydrous ether are added. The mixture is refluxed for one hour (during which time propane is evolved) and then 5 cc of cyclopentanone in 25 cc of anhydrous ether are added dropwise. The mixture is then refluxed for one hour and poured over ice water containing some hydrochloric acid. The ether solution is separated and extracted with 200 cc of 5% sodium hydroxide. The alkaline solution on acidification gives the free acid which is filtered off, dried in a desiccator and recrystallized from a mixture of ethylene dichloride and petroleum ether.
The product is 2-phenyl-2-(1-hydroxycyclopentyl)ethanoic acid, melting at 95° to 97°C. Of this product, 4.5 g in 30 cc of dry isopropyl alcohol are refluxed for 16 hours with 2.5 g of β-chloroethyl dimethyl amine. The solution is cooled and filtered clear from the solid by-product. The solvent is removed under reduced pressure on the steam bath and the residue is washed with anhydrous ether. It is dissolved in ethyl acetate from which it crystallizes. It is the hydrochloride of β-(dimethylamino)ethyl ester of 2-phenyl-2-(1- hydroxycyclopentyl) ethanoic acid, melting at 134° to 136°C.

brand name

Akpentolate (Akorn); Cyclogyl (Alcon); Pentolair (Bausch & Lomb); Pentolair (Pharmafair).

Therapeutic Function

Anticholinergic (ophthalmic)

General Description

Cyclopentolatehydrochloride, 2-dimethylaminoethyl 1-hydroxy- -phenylcyclopentaneacetatehydrochloride (Cyclogyl), is a crystalline,white, odorless solid that is very soluble in water,easily soluble in alcohol, and only slightly soluble in ether.A 1% solution has a pH of 5.0 to 5.4.
Cyclopentolate hydrochloride has one half of the antispasmodicactivity of atropine and is nonirritating when instilledrepeatedly into the eye. If not neutralized after the refractionstudies, its effect dissipates within 24 hours. Neutralizationwith a few drops of pilocarpine nitrate solution, 1% to 2%,often results in complete recovery in 6 hours. It is supplied asa ready-made ophthalmic solution in concentrations of either0.5% or 2%.

Clinical Use

Cyclopentolate Hydrochloride is used only for its effects on the eye, where it acts asa parasympatholytic. When placed in the eye, it quickly producescycloplegia and mydriasis. Its primary field of usefulnessis in refraction studies. Cyclopentolate hydrochloridecan be used, however, as a mydriatic in the management ofiritis, iridocyclitis, keratitis, and choroiditis. Although itdoes not seem to affect intraocular tension significantly, it isbest to be very cautious with patients with high intraocularpressure and with elderly patients with possible unrecognizedglaucomatous changes.

References

[1] S LAZARENO F F R N J Buckley. Characterization of muscarinic M4 binding sites in rabbit lung, chicken heart, and NG108-15 cells.[J]. Molecular Pharmacology, 1990, 38 6: 805-815.
[2] H ISHIKAWA P N P L DeSantis. Selectivity of muscarinic agonists including (+/-)-aceclidine and antimuscarinics on the human intraocular muscles.[J]. Journal of Ocular Pharmacology and Therapeutics, 1998, 14 4: 363-373. DOI: 10.1089/jop.1998.14.363

CYCLOPENTOLATE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CYCLOPENTOLATE HYDROCHLORIDE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Cyclopentolate Hydrochloride 5870-29-1
Price: US $2.00/KG
Min. Order: 120g
Purity: 99%
Supply Ability: 30kg
Release date: 2021-12-09

5870-29-1, CYCLOPENTOLATE HYDROCHLORIDERelated Search:

Olopatadine hydrochloride Cyclopentaneacetic acid, 2-(dimethylamino)ethyl ester, hydrochloride CYCLOPENTYLACETIC ACID 3-HYDROXY-3-METHYLHEXANOIC ACID CYCLOPENTOLATE DL-TROPIC ACID CYCLOPENTOLATE HYDROCHLORIDE 3-METHYL-2-PHENYLVALERIC ACID alpha,alpha-diethylphenethyl alcohol ALPHA-PHENYLCYCLOPENTANEACETIC ACID ETHYL (S)-3-HYDROXYHEXANOATE

2-(dimethylamino)ethyl1-hydroxy-alpha-phenylcyclopentaneacetatehydrochlorid

alpha-(1-hydroxycyclopentyl)-benzeneaceticaci2-(dimethylamino)ethylest

2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate hydrochloride

2-dimethylaminoethyl 2-(1-hydroxycyclopentyl)-2-phenyl-ethanoate hydrochloride

Cyclopentolate Hydrochloride (300 mg)

2-DIMETHYLAMINOETHYL 1-HYDROXY-ALPHA-PHENYLCYCLOPENTANEACETATE HYDROCHLORIDE

Cyclopentolate HCl USP

Benzeneacetic acid, a-(1-hydroxycyclopentyl)-,2-(diMethylaMino)ethyl ester, hydrochloride (1:1)

-2-phenylacetate hydrochloride

ethyl 2-(1-hydroxycyclopentyl)

N,N-Dimethylaminoethyl-a-(1-Hydroxycyclopentyl)phenylacetate hydrochloride

beta-dimethylaminoethyl(1-hydroxycyclopentyl)phenylacetatehydrochloride

cyclogyl

cyclopentaneaceticacid,1-hydroxy-alpha-phenyl-,2-(dimethylamino)ethylester,

2-dimethylaminoethyl 1-hydroxy-α-phenylcyclopentaneacetate

CYCLOPENTOLATEHYDROCHLORIDE,USP

2-(Dimethylamino)ethyl 1-hydroxy-α-phenylcyclopentaneacetate hydrochloride

Ak-Pentolate

Alnide

Cyclopentaneacetic acid, 1-hydroxy-a-phenyl-, 2-(dimethylamino)ethyl ester hydrochloride (8CI)

Mydplegic

Zyklolat

β-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate hydrochloride

Cyclogyl hydrochloride

2-(1-hydroxycyclopentyl)-2-phenyl-acetic acid 2-dimethylaminoethyl ester hydrochloride

2-(2-(1-hydroxycyclopentyl)-2-phenylacetoxy)ethyldimethylammonium chloride

1-Hydroxy-α-phenylcyclopentane acetic acid, 2-[dimethylamino] ethyl ester hydrochloride

LABOTEST-BB LT00244824

CYCLOPENTOLATE HYDROCHLORIDE

Cyclopentolate for system suitability CRS

Cyclopentolate hydrochloride CRS

2-(Dimethylamino)ethyl (2RS)-(1-hydroxycyclopentyl)-(phenyl)acetate hydrochloride

Cyclopentolate hydrochloride EP Impurity C

Cyclopentolate HydrochlorideQ: What is Cyclopentolate Hydrochloride Q: What is the CAS Number of Cyclopentolate Hydrochloride Q: What is the storage condition of Cyclopentolate Hydrochloride Q: What are the applications of Cyclopentolate Hydrochloride

Cyclopentolate Hydrochloride (1156000)

5-Hydroxy-1

Cyclopentodeester (hydrochloride)

Cyclopentolate Hydrochloride, 10 mM in DMSO

Cyclopentolate hydrochloride【BP380】

5870-29-1

C17H25NO3HCl

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