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NPGB

Product Name
NPGB
CAS No.
19135-17-2
Chemical Name
NPGB
Synonyms
NPGB;PNPGB;Nsc163801;P-NITROPHENYL P'-GUANIDINOBENZOATE HCL;4-NITROPHENYL 4-GUANIDINOBENZOATE &;4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE;p-nitrophenyl-p'-guanidinobenzoateHClcrystalline;4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE
CBNumber
CB6287205
Molecular Formula
C14H13ClN4O4
Formula Weight
336.73
MOL File
19135-17-2.mol
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NPGB Property

Melting point:
241-243 °C
storage temp. 
-20°C
form 
Solid
color 
White to off-white
BRN 
8024554
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
8-10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N8010
Product name
4-Nitrophenyl 4-guanidinobenzoate hydrochloride
Purity
protease inhibitor and substrate
Packaging
500mg
Price
$284
Updated
2024/03/01
Sigma-Aldrich
Product number
N8010
Product name
4-Nitrophenyl 4-guanidinobenzoate hydrochloride
Purity
protease inhibitor and substrate
Packaging
1g
Price
$506
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
CHM0114939
Product name
4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
Purity
95.00%
Packaging
500MG
Price
$719.17
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0114939
Product name
4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
Purity
95.00%
Packaging
1G
Price
$999.36
Updated
2021/12/16
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NPGB Chemical Properties,Usage,Production

Uses

4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:

  • as a substrate for trypsin for active site titration experiments
  • for pre-treating of mosquito eggs in the interplasmid transposition assay
  • as a component of isotonic buffer to moisten filter paper for mosquito embryo collection

General Description

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.

Biochem/physiol Actions

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.

References

[1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:10.1016/j.bbapap.2017.12.002.
[2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:10.1111/j.1432-1033.1980.tb04829.x.
[3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:10.1016/j.peptides.2008.05.025.
[4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:10.1016/0022-1759(85)90305-9.
[5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:10.1021/jm00154a015.

NPGB Preparation Products And Raw materials

Raw materials

Preparation Products

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NPGB Suppliers

Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Beijing Haite lesk Technology Co., Ltd
Tel
15210893940; 15116916250
Fax
QQ: 237008221
Email
chemistryliu@163.com
Country
China
ProdList
7326
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shaanxi Dideu Newmaterial Co., Ltd.
Tel
029-87576359 15353716720
Email
1039@dideu.com
Country
China
ProdList
10009
Advantage
58
Shanghai Yingxin laboratory equipment Co., Ltd
Tel
021-021-59178156 15300768757
Email
359382369@qq.com
Country
China
ProdList
10674
Advantage
58
Shanghai Guchen Biotechnology Co., LTD
Tel
021-34675735 19147740836
Email
1986399151@qq.com
Country
China
ProdList
9844
Advantage
58

19135-17-2, NPGBRelated Search:


  • 4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE
  • 4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
  • NPGB
  • PNPGB
  • P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE
  • P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE
  • P'-GUANIDINOBENZOIC ACID P-NITROPHENYL ESTER HYDROCHLORIDE
  • Nsc163801
  • 4-nitrophenyl 4-[(aminoiminomethyl)amino]benzoate monohydrochloride
  • P-NITROPHENYL P'-GUANIDINOBENZOATE HCL
  • 4-NITROPHENYL 4-GUANIDINOBENZOATE &
  • p-nitrophenyl-p'-guanidinobenzoateHClcrystalline
  • p-Nitrophenyl-p'-guanidinobenzoatehydrochloridecrystalline
  • Benzoic acid, 4-(aminoiminomethyl)amino-, 4-nitrophenyl ester, monohydrochloride
  • 4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB
  • 4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate
  • (4-nitrophenyl)4-(diaminomethylideneamino)benzoate,hydrochloride
  • 19135-17-2
  • C14H12N4O4HCl
  • Substrates by Enzyme
  • Chromogenic
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Substrates
  • Activity
  • BioChemical
  • Biochemicals and Reagents