NPGB
- Product Name
- NPGB
- CAS No.
- 19135-17-2
- Chemical Name
- NPGB
- Synonyms
- NPGB;PNPGB;Nsc163801;P-NITROPHENYL P'-GUANIDINOBENZOATE HCL;4-NITROPHENYL 4-GUANIDINOBENZOATE &;4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE;p-nitrophenyl-p'-guanidinobenzoateHClcrystalline;4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE
- CBNumber
- CB6287205
- Molecular Formula
- C14H13ClN4O4
- Formula Weight
- 336.73
- MOL File
- 19135-17-2.mol
NPGB Property
- Melting point:
- 241-243 °C
- storage temp.
- -20°C
- form
- Solid
- color
- White to off-white
- BRN
- 8024554
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N8010
- Product name
- 4-Nitrophenyl 4-guanidinobenzoate hydrochloride
- Purity
- protease inhibitor and substrate
- Packaging
- 500mg
- Price
- $284
- Updated
- 2024/03/01
- Product number
- N8010
- Product name
- 4-Nitrophenyl 4-guanidinobenzoate hydrochloride
- Purity
- protease inhibitor and substrate
- Packaging
- 1g
- Price
- $506
- Updated
- 2024/03/01
- Product number
- CHM0114939
- Product name
- 4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 500MG
- Price
- $719.17
- Updated
- 2021/12/16
- Product number
- CHM0114939
- Product name
- 4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $999.36
- Updated
- 2021/12/16
NPGB Chemical Properties,Usage,Production
Uses
4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:
- as a substrate for trypsin for active site titration experiments
- for pre-treating of mosquito eggs in the interplasmid transposition assay
- as a component of isotonic buffer to moisten filter paper for mosquito embryo collection
General Description
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.
Biochem/physiol Actions
4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.
References
[1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:10.1016/j.bbapap.2017.12.002.
[2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:10.1111/j.1432-1033.1980.tb04829.x.
[3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:10.1016/j.peptides.2008.05.025.
[4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:10.1016/0022-1759(85)90305-9.
[5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:10.1021/jm00154a015.
NPGB Preparation Products And Raw materials
Raw materials
Preparation Products
NPGB Suppliers
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