NPGB

Product Name: NPGB
CAS No.: 19135-17-2
Chemical Name: NPGB
Synonyms: NPGB;PNPGB;Nsc163801;P-NITROPHENYL P'-GUANIDINOBENZOATE HCL;4-NITROPHENYL 4-GUANIDINOBENZOATE &;4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE;P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE;p-nitrophenyl-p'-guanidinobenzoateHClcrystalline;4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE
CBNumber: CB6287205
Molecular Formula: C14H13ClN4O4
Formula Weight: 336.73
MOL File: 19135-17-2.mol

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NPGB Property

Melting point:: 241-243 °C
storage temp.: -20°C
BRN: 8024554

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
F: 8-10

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N8010
Product name: 4-Nitrophenyl 4-guanidinobenzoate hydrochloride
Purity: protease inhibitor and substrate
Packaging: 500mg
Price: $284
Updated: 2024/03/01

Sigma-Aldrich

Product number: N8010
Product name: 4-Nitrophenyl 4-guanidinobenzoate hydrochloride
Purity: protease inhibitor and substrate
Packaging: 1g
Price: $506
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: CHM0114939
Product name: 4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
Purity: 95.00%
Packaging: 500MG
Price: $719.17
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0114939
Product name: 4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $999.36
Updated: 2021/12/16

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NPGB Chemical Properties,Usage,Production

Uses

4-Nitrophenyl 4-guanidinobenzoate hydrochloride has been used:

as a substrate for trypsin for active site titration experiments
for pre-treating of mosquito eggs in the interplasmid transposition assay
as a component of isotonic buffer to moisten filter paper for mosquito embryo collection

General Description

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) is a trypsin substrate. It is more water-soluble than 4-methylumbelliferyl 4-guanidinobenzoate and is preferred in spectrophotometric assay.

Biochem/physiol Actions

4-Nitrophenyl 4-guanidinobenzoate hydrochloride (pNPGB) inhibits phenoloxidase enzyme and delays embryo chorionic membrane hardening.

References

[1] BHUMI PATEL . L. donovani XPRT: Molecular characterization and evaluation of inhibitors[J]. Biochimica et biophysica acta. Proteins and proteomics, 2018, 1866 3: Pages 426-441. DOI:10.1016/j.bbapap.2017.12.002.
[2] FRANK S. STEVEN Margaret M G. Studies on the Molecular Mechanism of Mersalyl and 4-Aminophenylmercuric Acetate Re-activation of Trypsin-Thiol Complexes[J]. The FEBS journal, 1980, 109 2: 567-573. DOI:10.1111/j.1432-1033.1980.tb04829.x.
[3] YING-YING HE . Isolation, expression and characterization of a novel dual serine protease inhibitor, OH-TCI, from king cobra venom[J]. Peptides, 2008, 29 10: Pages 1692-1699. DOI:10.1016/j.peptides.2008.05.025.
[4] J.A. SCHIFFERLI G. S. A simple two-step procedure for the preparation of the first component of human complement (C1) in its native form[J]. Journal of immunological methods, 1985, 76 2: Pages 283-288. DOI:10.1016/0022-1759(85)90305-9.
[5] J. M. KAMINSKI. Synthesis and inhibition of human acrosin and trypsin and acute toxicity of aryl 4-guanidinobenzoates[J]. Journal of Medicinal Chemistry, 1986, 29 4: 514-519. DOI:10.1021/jm00154a015.

NPGB Preparation Products And Raw materials

Raw materials

Preparation Products

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NPGB Suppliers

China 7 Germany 1 Japan 1 South Korea 1 Switzerland 1 United States 3 Global 14

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Beijing Haite lesk Technology Co., Ltd

Tel: 15210893940; 15116916250
Fax: QQ: 237008221
Email: chemistryliu@163.com
Country: China
ProdList: 7327
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44941
Advantage: 58

Shaanxi Dideu Newmaterial Co., Ltd.

Tel: 029-63373950 15353716720
Email: 1052@dideu.com
Country: China
ProdList: 10008
Advantage: 58

Shanghai Yingxin laboratory equipment Co., Ltd

Tel: 021-021-59178156 15300768757
Email: 359382369@qq.com
Country: China
ProdList: 10679
Advantage: 58

Shanghai Guchen Biotechnology Co., LTD

Tel: 021-34675735 19147740836
Email: 1986399151@qq.com
Country: China
ProdList: 9849
Advantage: 58

19135-17-2, NPGBRelated Search:

1-phenylguanidine 4-(Methylamino)benzoic acid 4-AMINOBENZOIC ACID HCL 4-BENZYLOXYANILINE 4-Guanidinobenzoic acid hydrochloride METHYL 4-METHYLAMINOBENZOATE 1-BENZYLOXY-4-NITROBENZENE 4-NITROPHENYL BENZOATE 4-Benzyloxyaniline hydrochloride Phenyl benzoate PHENYL 4-AMINOBENZOATE N-P-TOLYL-GUANIDINE HYDROCHLORIDE P-PHENETIDINE HYDROCHLORIDE N-P-TOLYL-GUANIDINE NPGB METHYL 4-AMINOBENZOATE HYDROCHLORIDE 4-(PHENOXYMETHYL)ANILINE 4-nitrophenyl 4'-guanidinobenzoate

4-GUANIDINOBENZOIC ACID 4-NITROPHENYL-ESTER HYDROCHLORIDE

4-NITROPHENYL 4-GUANIDINOBENZOATE HYDROCHLORIDE

NPGB

PNPGB

P-NITROPHENYL P'-GUANIDINOBENZOATE HYDROCHLORIDE

P-NITROPHENYL-P-GUANIDINOBENZOATE HYDROCHLORIDE

P'-GUANIDINOBENZOIC ACID P-NITROPHENYL ESTER HYDROCHLORIDE

Nsc163801

4-nitrophenyl 4-[(aminoiminomethyl)amino]benzoate monohydrochloride

P-NITROPHENYL P'-GUANIDINOBENZOATE HCL

4-NITROPHENYL 4-GUANIDINOBENZOATE &

p-nitrophenyl-p'-guanidinobenzoateHClcrystalline

p-Nitrophenyl-p'-guanidinobenzoatehydrochloridecrystalline

Benzoic acid, 4-(aminoiminomethyl)amino-, 4-nitrophenyl ester, monohydrochloride

4-Guanidinobenzoic acid 4-nitrophenylester hydrochloride, NPGB, pNPGB

4-Nitrophenyl 4-guanidinobenzoate hydrochloride protease inhibitor and substrate

(4-nitrophenyl)4-(diaminomethylideneamino)benzoate,hydrochloride

19135-17-2

C14H12N4O4HCl

Substrates by Enzyme

Chromogenic

Enzymes, Inhibitors, and Substrates

Enzyme Substrates

Activity

BioChemical

Biochemicals and Reagents