4-Guanidinobenzoic acid hydrochloride
- Product Name
- 4-Guanidinobenzoic acid hydrochloride
- CAS No.
- 42823-46-1
- Chemical Name
- 4-Guanidinobenzoic acid hydrochloride
- Synonyms
- 4-g;TIMTEC-BB SBB003396;4-Guanidinobenzoic a;p-Guanidinobenzoic acid;Taletrectinib Impurity10;Nafamostat Impurity 9 HCl;Nafamostat Impurity 6 HCl;4-GUANIDINOBENZOIC ACID HCL;uanidinobenzoic Acid HydrochL;4-Guanidinobenzoic hydrochoride
- CBNumber
- CB3319514
- Molecular Formula
- C8H10ClN3O2
- Formula Weight
- 215.64
- MOL File
- 42823-46-1.mol
4-Guanidinobenzoic acid hydrochloride Property
- Melting point:
- 285 °C (dec.)(lit.)
- storage temp.
- 2-8°C
- solubility
- DMSO,(Slightly) Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- soluble
- BRN
- 3718032
- InChI
- InChI=1S/C8H9N3O2.ClH/c9-8(10)11-6-3-1-5(2-4-6)7(12)13;/h1-4H,(H,12,13)(H4,9,10,11);1H
- InChIKey
- YETFLAUJROGBMC-UHFFFAOYSA-N
- SMILES
- C1(NC(=N)N)=CC=C(C(=O)O)C=C1.Cl
- CAS DataBase Reference
- 42823-46-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 374962
- Product name
- 4-Guanidinobenzoic acid hydrochloride
- Purity
- 99%
- Packaging
- 5g
- Price
- $46.1
- Updated
- 2023/06/20
- Product number
- G0238
- Product name
- 4-Guanidinobenzoic Acid Hydrochloride
- Purity
- >97.0%(T)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- G0238
- Product name
- 4-Guanidinobenzoic Acid Hydrochloride
- Purity
- >97.0%(T)
- Packaging
- 25g
- Price
- $52
- Updated
- 2025/07/31
- Product number
- G9027
- Product name
- 4-Guanidinobenzoic Acid, Hydrochloride Salt
- Packaging
- 5g
- Price
- $403
- Updated
- 2021/12/16
- Product number
- G821300
- Product name
- 4-GuanidinobenzoicAcidHydrochlorideSalt
- Packaging
- 25g
- Price
- $65
- Updated
- 2021/12/16
4-Guanidinobenzoic acid hydrochloride Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Aminobenzoic acid derivatives for treatment of chronic inflammatory diseases
Uses
4-Guanidinobenzoic acid hydrochloride may be used in ELISA inhibition assay of mouse antiserum. It may be used in the synthesis of human acrosin inhibitor 4′-acetaminophenyl 4-guanidinobenzoate hydrochloride.2
General Description
4-Guanidinobenzoic acid hydrochloride is a guanidine derivative. Quality standard of 4-guanidinobenzoic acid hydrochloride has been investigated.
Synthesis
420-04-2
150-13-0
42823-46-1
1. To a stirred suspension of 4-aminobenzoic acid (50 g, 0.364 mol) in a concentrated hydrochloric acid/water (46 mL/283 mL) mixture was added cyanamide (35 g, 0.839 mol) at room temperature. 2. The reaction mixture was heated to reflux at 100°C for 6 hours. 3. After completion of the reaction, the mixture was allowed to stand at room temperature for 16 hours (without stirring). 4. The precipitated solid was collected by filtration and washed with cold water (100 mL). 5. Suspend the resulting solid in aqueous potassium carbonate (30 g K2CO3 dissolved in 400 mL of water) and stir for 30 minutes. 6. The solid was filtered again, washed with water (250 mL) and subsequently dried under vacuum to afford the intermediate Int-2A (35 g, 53% yield) as a white solid. 7. Acetyl chloride (35 mL, 490 mmol) was slowly added dropwise to a stirred methanol (350 mL) suspension of Int-2A (35 g, 195.5 mmol) at 0°C and protected by an inert atmosphere for 20 minutes. 8. After the dropwise addition, the reaction mixture was stirred at room temperature for 16 hours. 9. After confirming complete consumption of the raw material by thin layer chromatography (TLC), the reaction mixture was neutralized with solid sodium bicarbonate at 0 °C. 10. Excess sodium bicarbonate was removed by filtration and the filtrate was concentrated under vacuum to give the crude product. 11. The crude product was washed with ethyl acetate (100 mL) to afford the purified intermediate Int-2B (35 g, 92% yield) as a white solid.
References
[1] Patent: US2010/29638, 2010, A1. Location in patent: Page/Page column 62
[2] European Journal of Medicinal Chemistry, 1996, vol. 31, # 11, p. 895 - 899
4-Guanidinobenzoic acid hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Guanidinobenzoic acid hydrochloride manufacturers
- Product
- N-(4-Carboxyphenyl)guanidine hydrochloride 42823-46-1
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 100kg
- Release date
- 2025-09-08
- Product
- 4-Guanidinobenzoic acid hydrochloride 42823-46-1
- Price
- US $205.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 1000KG
- Release date
- 2021-06-04
- Product
- 4-Guanidinobenzoic acid hydrochloride 42823-46-1
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10MT
- Release date
- 2018-12-17