Anti-TDP-43
- Product Name
- Anti-TDP-43
- Chemical Name
- Anti-TDP-43
- Synonyms
- Anti-TDP-43;Anti-TAR DNA binding protein;Anti-TARDBP (ab1) antibody produced in rabbit;Anti-TARDBP (ab2) antibody produced in rabbit
- CBNumber
- CB62903372
- Formula Weight
- 0
- MOL File
- Mol file
Anti-TDP-43 Property
- storage temp.
- -20°C
- form
- buffered aqueous solution
- biological source
- rabbit
Safety
- WGK Germany
- WGK 1
- Storage Class
- 10 - Combustible liquids
Anti-TDP-43 Chemical Properties,Usage,Production
Uses
Anti-TARDBP (AB1) polyclonal antibody is used to tag TAR DNA binding protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of TAR DNA binding protein in the repression of gene expression and regulation of pre-mRNA splicing and translation.
Biological Activity
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome th at produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator T at is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. TARDBP is a transcriptional repressor th at binds to chromosomally integrated TAR DNA and represses HIV-1 transcription.HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome th at produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator T at is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor th at binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Anti-TDP-43 Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-TDP-43 Suppliers
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