(6-METHOXY-PYRIDIN-2-YL)-METHANOL
- Product Name
- (6-METHOXY-PYRIDIN-2-YL)-METHANOL
- CAS No.
- 63071-12-5
- Chemical Name
- (6-METHOXY-PYRIDIN-2-YL)-METHANOL
- Synonyms
- Zinc04352715;6-Methoxy-2-PyridineMethanol;(6-methoxy-2-pyridyl)methanol;2-Pyridinemethanol,6-methoxy-;(6-methoxy-2-pyridinyl)methanol;(6-METHOXY-PYRIDIN-2-YL)-METHANOL;6-Methoxy-2-(hydroxymethyl)pyridine
- CBNumber
- CB6291352
- Molecular Formula
- C7H9NO2
- Formula Weight
- 139.15
- MOL File
- 63071-12-5.mol
(6-METHOXY-PYRIDIN-2-YL)-METHANOL Property
- Boiling point:
- 72-73 °C(Press: 0.06 Torr)
- Density
- 1.155±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 13.22±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000358
- Product name
- (6-Methoxy-pyridin-2-yl)-methanol
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $463
- Updated
- 2023/01/07
- Product number
- M222805
- Product name
- (6-Methoxypyridin-2-yl)methanol
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- M222805
- Product name
- (6-Methoxypyridin-2-yl)methanol
- Packaging
- 250mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 023791
- Product name
- (6-Methoxy-pyridin-2-yl)-methanol
- Purity
- 97%
- Packaging
- 250mg
- Price
- $124
- Updated
- 2021/12/16
- Product number
- 023791
- Product name
- (6-Methoxy-pyridin-2-yl)-methanol
- Purity
- 97%
- Packaging
- 500g
- Price
- $191
- Updated
- 2021/12/16
(6-METHOXY-PYRIDIN-2-YL)-METHANOL Chemical Properties,Usage,Production
Synthesis
26256-72-4
63071-12-5
General procedure for the synthesis of 6-methoxy-2-pyridinemethanol from 6-methoxypyridine-2-carboxylic acid methyl ester: 6-methoxypyridine-2-carboxylic acid methyl ester (2 g, 11.96 mmol) was dissolved in anhydrous methanol (20 mL) and cooled down to 0 °C under nitrogen protection. Sodium borohydride (1.36 g, 35.89 mmol) was slowly added and the reaction system was kept stirred at 0 °C for 30 min. Subsequently, the reaction system was slowly warmed to room temperature and stirring was continued for 1 hour. After completion of the reaction, the reaction was quenched with water and the reaction mixture was concentrated on a rotary evaporator. The concentrated mixture was diluted with brine (100 mL) and then extracted with a mixture of dichloromethane and 2-propanol (2:1, 3 x 150 mL, by volume). The organic phases were combined, dried with magnesium sulfate, filtered, and concentrated on a rotary evaporator to give 6-methoxy-2-pyridinemethanol (500 mg, 30% yield) as an oily product. Mass spectrometry analysis showed [M+H]+ calculated value of 140.1 and measured value of 140.1.
References
[1] Patent: US2009/274632, 2009, A1
[2] Patent: US9247759, 2016, B2. Location in patent: Page/Page column 303
[3] Patent: US2016/376263, 2016, A1. Location in patent: Paragraph 0469; 0470
[4] Patent: WO2014/3483, 2014, A1. Location in patent: Page/Page column 34
[5] Patent: WO2011/79076, 2011, A1. Location in patent: Page/Page column 93
(6-METHOXY-PYRIDIN-2-YL)-METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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