Cefodizime

Product Name: Cefodizime
CAS No.: 69739-16-8
Chemical Name: Cefodizime
Synonyms: FIR-221;Estrofan;Cefodizme;Cefodizim;CEFODIZIME;Cefodizime,CDZM;CefodizMe SodiuM;Sodium cefodizime;Cefodizime USP/EP/BP;CEFODIZIME FREE ACID
CBNumber: CB6299020
Molecular Formula: C20H20N6O7S4
Formula Weight: 584.67
MOL File: 69739-16-8.mol

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Cefodizime Property

Melting point:: >170°C (dec.)
alpha: D25 -55.9°
Density: 1.86±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: pK1 2.85; pK2 3.37; pK3 4.18(at 25℃)
color: White to Off-White
CAS DataBase Reference: 69739-16-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-42/43
Safety Statements: 22-26-36/37/39

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C242865
Product name: Cefodizime
Packaging: 25mg
Price: $50
Updated: 2021/12/16

TRC

Product number: C242865
Product name: Cefodizime
Packaging: 1g
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0028575
Product name: Cefodizime
Purity: ≥97.0%
Packaging: 50mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0028575
Product name: Cefodizime
Purity: ≥97.0%
Packaging: 100mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: K170
Product name: Cefodizime
Packaging: 25mg
Price: $38
Updated: 2021/12/16

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Cefodizime Chemical Properties,Usage,Production

Chemical Properties

Cefodizime Sodium is a white to light yellowish white crystalline powder. It has no odor or a slightly peculiar odor and has a bitter taste. It is highly soluble in water (around 270g/L) but only sparingly soluble in ethanol or ether.

Uses

Cefodizime is a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or treatment of surgical infections.

Definition

ChEBI: Cefodizime is a cephalosporin compound having 5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. It has a role as an antibacterial drug and an EC 1.14.18.1 (tyrosinase) inhibitor. It is a cephalosporin, a member of 1,3-thiazoles and an oxime O-ether.

Preparation

The synthesis of cefodizime involved the following steps:
Dissolve 6.1g of (2-mercapto-4-methylthiazol-5-yl) acetic acid in water and adjust the pH to 6.5 by adding 2 mol/L sodium hydroxide.
Heat the solution to 70°C and then add a solution of 12g of cefotaxime in 75ml of water with stirring.
Keep stirring the mixture at 70°C for 3 hours while maintaining the pH at 6.5 by adding 2 mol/L sodium hydroxide.
Cool the mixture to room temperature and acidify it to pH 2.8.
Filter the resulting precipitate and wash it with water.
Dry the precipitate under vacuum and in the presence of phosphorus pentoxide.
As a result, 10g of cefodizime is obtained.
Cefodizime, an aminothiazolylcephalosporin. V. Synthesis and structure-activity relationships in the cefodizime series. DOI: 10.7164/antibiotics.40.29

Cefodizime Preparation Products And Raw materials

Raw materials

2-Mercapto-4-methyl-5-thiazoleacetic acid Cefotaxime Ethyl acetate 2-Aminothiazole-4-acetic acid Cyclohexylurea 1-Hydroxybenzotriazole hydrate Dicyclohexylcarbodiimide Formamide

Preparation Products

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Cefodizime Suppliers

Canada 1 China 132 Europe 3 Germany 1 India 3 United Kingdom 6 United States 15 Global 161

Shanghai Norky Pharmaceutical Co., Ltd.

Tel: 021-021-61075308 15216782696
Fax: 021-61075308
Email: sales@norkysh.com
Country: China
ProdList: 65
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

LGM Pharma

Tel: 1-(800)-881-8210
Fax: 615-250-9817
Email: inquiries@lgmpharma.com
Country: United States
ProdList: 2123
Advantage: 70

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768850
Email: 1791901229@qq.com
Country: China
ProdList: 8843
Advantage: 52

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

BOC Sciences

Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 14055
Advantage: 65

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2871
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

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View Lastest Price from Cefodizime manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Cefodizime 69739-16-8
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-10-14

Hebei Weibang Biotechnology Co., Ltd

Product: Cefodizime 69739-16-8
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2021-11-11

Hebei Mojin Biotechnology Co., Ltd

Product: Cefodizime 69739-16-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-15

69739-16-8, CefodizimeRelated Search:

2-Mercapto-4-methyl-5-thiazoleacetic acid Oxygen Cefodizime sodium Ceftizoxime 4-METHYLTHIAZOLE-2-THIOL 2-Mercapto-4-methyl-1,3-thiazol-5-yl-acetic acid Ceftizoxime sodium Cefetamet hydrochloride Cefodizime 2-MERCAPTO-4-METHYL-5-HYDROXYETHYLTHIAZOLE 2-(2-AMINOTHIAZOL-4-YL)ETHYLAMINE 4-METHYL-5-THIAZOLEACETIC ACID 4,5-DIMETHYL-THIAZOLE-2-THIOL 4-Thiazoleacetamide 2-(2-AMINO-THIAZOL-4-YL)-ACETAMIDE 1,3-THIAZOL-5-YLACETIC ACID Desfuroyl Ceftiofur 2-MERCAPTO_4_METHYI_1,3-THIAZOL-5-YL-ACETIC ACID

Cefodizim

CEFODIZIME

Cefodizime,CDZM

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6R,7R)-

7-(α-(Z)-Methoxyimino-α-(2-aminothiazol-4-yl)acetamido)-3-((5-carboxymethyl-4-methylthiazol-2-yl)thiomethyl)-3-cephem-4-carboxylic acid

7-(((2-Amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-(((5-(carboxymethyl)-4-methyl-2-thiazolyl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid

FIR-221

Cefodizme

CefodizMe SodiuM

Sodium cefodizime

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(methoxyimino)acetyl]amino]-3-[[[5-(carboxymethyl)-4-methyl-2-thiazolyl]thio]methyl]-8-oxo-, (6R,7R)-

Cefodizime USP/EP/BP

CefodiziMe acid USP/EP/BP

CEFODIZIME FREE ACID

(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(methoxyimino)acetamido)-3-(((5-(carboxymethyl)-4-methylthiazol-2-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Estrofan

69739-16-8

C20H20N6O7S4

C20H19N6NaO7S4

Pharmaceutical intermediate