OLIGOMYCIN B

Product Name: OLIGOMYCIN B
CAS No.: 11050-94-5
Chemical Name: OLIGOMYCIN B
Synonyms: OLIGOMYCIN B;28-Oxooligomycin A;Oligomycin A, 28-oxo-;OLIGOMYCIN B USP/EP/BP;OligoMycin B froM StreptoMyces;OLIGOMYCIN B, STREPTOMYCES DIASTATOCHROMOGENES;Oligomycin B fromStreptomyces diastatochromogenes;Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,3',9,13(4'H)-tetrone, 22-ethyl-5',6'-dihydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'S,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-
CBNumber: CB6300711
Molecular Formula: C45H72O12
Formula Weight: 805.05
MOL File: 11050-94-5.mol

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OLIGOMYCIN B Property

Melting point:: 160-161℃
Boiling point:: 911.4±65.0 °C(Predicted)
Density: 1.19 g/cm3
storage temp.: −20°C
solubility: ≤30mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide
pka: 12.52±0.70(Predicted)
form: White to off-white powder.
Merck: 13,6902

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Safety

Hazard Codes: Xn,T
Risk Statements: 20/21/22-68/20/21/22-22
Safety Statements: 36/37
RIDADR: 2811
WGK Germany: 3
RTECS: RK3330000
F: 3-10
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29419090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 11343
Product name: Oligomycin B
Purity: ≥95%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 11343
Product name: Oligomycin B
Purity: ≥95%
Packaging: 5mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 11343
Product name: Oligomycin B
Purity: ≥95%
Packaging: 10mg
Price: $216
Updated: 2024/03/01

TRC

Product number: O532975
Product name: OligomycinB
Packaging: 5mg
Price: $115
Updated: 2021/12/16

Usbiological

Product number: O6154-01
Product name: Oligomycin B
Packaging: 5mg
Price: $368
Updated: 2021/12/16

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OLIGOMYCIN B Chemical Properties,Usage,Production

Description

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin B is a nonselective inhibitor of the mitochondrial F₁F_O ATP synthase. Oligomycin B (1-10 μM) can reduce the rate of ATP depletion in myocardial ischemia and decrease calcium-induced calcium release oscillation frequency of rat sensory neurons.

Uses

Oligomycin B, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.

Uses

Oligomycin B is an antibiotic that acts as a nonselective inhibitor of ATP synthase.

in vitro

previous study found that oligomycin b and aurovertin b were able to inhibit both the synthase and the hydrolase function, which not only rendered them difficult to be experimentally used, but also precluded them from being therapeutics. aurovertin b bound between the subunits catalytic f1 domain of the f1f0 atpase, where it prevented the conformational changes required for the catalytic cycle of this enzyme, whereas oligomycin bound to the f0 domain and blocked proton flow [1].

in vivo

in a previous animal study, intracranial pressure measurements were performed in sd rats treated by intraperitoneal injection of vehicle, cyclosporine a, or oligomycin b. it was found that cerebral edema and mitochondrial impairment could be significantly worsened by treatment with oligomycin b, whereas a noticeable improvement could be observed in animals that received injections of cyclosporine a [2].

References

[1] g. j. grover and j. malm. pharmacological profile of the selective mitochondrial f1f0 atp hydrolase inhibitor bms-199264 in myocardial ischemia. cardiovasc.ther. 26, 287-296 (2008).
[2] vlodavsky e, palzur e, shehadeh m, soustiel jf. post-traumatic cytotoxic edema is directly related to mitochondrial function. j cereb blood flow metab. 2017 jan;37(1):166-177.

OLIGOMYCIN B Preparation Products And Raw materials

Raw materials

Preparation Products

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OLIGOMYCIN B Suppliers

China 81 Germany 2 Switzerland 1 United Kingdom 9 United States 17 Global 110

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View Lastest Price from OLIGOMYCIN B manufacturers

Career Henan Chemical Co

Product: OLIGOMYCINB 11050-94-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: kg/T
Release date: 2019-12-18

11050-94-5, OLIGOMYCIN BRelated Search:

2,6-HEPTANEDIONE TRANS-2-OCTENOIC ACID 8,10-DODECADIEN-1-OL OLIGOMYCIN B 3-Hydroxy-3-methyl-2-butanone 1,7-DIOXASPIRO[5.5]UNDECANE ISOOCTYL ACRYLATE N-OCTYL ACRYLATE 2-UNDECENOIC ACID METHYL 4-METHYL-2-PENTENOATE ETHYL TRANS-2-OCTENOATE Methyl trans-2-nonenoate 3,3-Dimethoxybutan-2-one N-HEPTYL ACRYLATE 2,4-DIMETHYL-3-HEPTANONE OLIGOMYCIN oligomycin D OLIGOMYCIN A

OLIGOMYCIN B

OLIGOMYCIN B, STREPTOMYCES DIASTATOCHROMOGENES

Oligomycin A, 28-oxo-

Oligomycin B fromStreptomyces diastatochromogenes

28-Oxooligomycin A

OligoMycin B froM StreptoMyces

Spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-triene-27,2'-[2H]pyran]-3,3',9,13(4'H)-tetrone, 22-ethyl-5',6'-dihydro-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-, (1R,2'S,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,28S,29R)-

OLIGOMYCIN B USP/EP/BP

11050-94-5

1105-94-5

C45H72O12

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