Physical Form
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Lumateperone

Physical Form
Product Name
Lumateperone
CAS No.
313368-91-1
Chemical Name
Lumateperone
Synonyms
Lumateperone;ITI-722;Lumepperone;Lumiperidone;ITI-722 lumateperone;Lumateperone ITI-722;Lumateperone, 10 mM in DMSO;313368-91-1Lumateperone(ITI-007);1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3‘,4‘:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)butan-1-one;1-(4-Fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone
CBNumber
CB63032893
Molecular Formula
C24H28FN3O
Formula Weight
393.5
MOL File
313368-91-1.mol
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Lumateperone Property

Boiling point:
556.4±50.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
pka
9.10±0.20(Predicted)
form 
Oil
color 
Colorless to light yellow
InChIKey
HOIIHACBCFLJET-SFTDATJTSA-N
SMILES
C(C1=CC=C(F)C=C1)(=O)CCCN1C[C@@]2([H])C3=CC=CC4=C3N([C@@]2([H])CC1)CCN4C
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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Lumateperone Chemical Properties,Usage,Production

Physical Form

white solid

Description

Lumateperone is a novel antipsychotic agent with a unique mechanism of action with high 5-hydroxytryptamine 2A(5-HT2A) blocking activity. A Phase 2 study in treatment of insomnia revealed strong evidence of efficacy, with no impairment of next-day cognition.

Uses

Lumateperone was a drug developed for the treatment of schizophrenia. May have applications in bipolar depression.

Synthesis

Synthesis of Lumateperone

in vivo

Lumateperone (i.p., 1-10 mg/kg) promotes NMDA and AMPA-induced currents in a dopamine D1 receptor-dependent manner and increases the release of dopamine and glutamate in rat mPFC slices[2].

Animal Model:Adult male Sprague-Dawley rats[2]
Dosage:1-10 mg/kg
Administration:Intraperitoneal injection
Result:Inhibited avoidance response at concentrations of 1, 3 and 10 mg/kg after 20 minutes.
Promoted NMDA and AMPA-sensitive currents, also significantly increased dopamine and glutamate release at 10 mg/kg in mPFC cone cells of rat.

IC 50

D1 Receptor; D2 Receptor

storage

Store at 0-8℃

References

[1] Patent: US2004/220178, 2004, A1

Lumateperone Preparation Products And Raw materials

Raw materials

Preparation Products

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Lumateperone Suppliers

Australia 1 China 90 India 5 United States 3 Global 99
Taizhou Yuxin Biotechnology Co., Ltd.,
Tel
+86-0576--88902229 +86-13968687450
Email
yuxin@yuxchem.com
Country
China
ProdList
265
Advantage
58
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-02136680027 15800370750
Email
1706640024@qq.com
Country
China
ProdList
570
Advantage
56
Jinan Sanyuan Chemical Co. LTD
Tel
0531-58582194; 18615587029
Fax
0531-58585914
Email
1660423085@qq.com
Country
China
ProdList
391
Advantage
58
Hangzhou Chemtrue Bio-Tech Co.,Ltd.
Tel
0571-86828652 18857119830
Fax
0571-83522824
Email
sales@chemtrue-bio.com
Country
China
ProdList
252
Advantage
58
Chengdu Aupone Pharmaceutical Co.,Ltd.
Tel
18980796919
Email
236656639@qq.com
Country
China
ProdList
30
Advantage
58
Shandong Fuchuang Pharmaceutical Technology Co. , Ltd.
Tel
18663705731
Email
fcpharm2006@126.com
Country
China
ProdList
205
Advantage
58
S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-4000505016 13380397412
Fax
0755 28094224
Email
3001272453@qq.com
Country
China
ProdList
5158
Advantage
50
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9510
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18333
Advantage
56
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9637
Advantage
58
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View Lastest Price from Lumateperone manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Lumateperone 313368-91-1
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
5g
Release date
2025-03-26
shandong perfect biotechnology co.ltd
Product
Lumateperone 313368-91-1
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
100g
Release date
2023-08-01
Chengdu Aupone Pharmaceutical Co.Ltd.
Product
Lumateperone 313368-91-1
Price
US $0.00/gram
Min. Order
10gram
Purity
99.99
Supply Ability
10Tons
Release date
2024-03-18

313368-91-1, LumateperoneRelated Search:


  • ITI-722
  • Lumateperone
  • ITI-722 lumateperone
  • 1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H-pyrido[3‘,4‘:4,5]pyrrolo[1,2,3-de]quinoxalin-8-yl)butan-1-one
  • 313368-91-1Lumateperone(ITI-007)
  • 1-Butanone, 1-(4-fluorophenyl)-4-[(6bR,10aS)-2,3,6b,9,10,10a-hexahydro-3-methyl-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-
  • 1-(4-fluorophenyl)-4-((6bR,10aS)-3-methyl-2,3,6b,7,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(9H)-yl)butan-1-one
  • 1-(4-Fluorophenyl)-4-[(6bR,10aS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7H)-yl]-1-butanone
  • presynaptic D2 receptor,dopamine D1 receptor,Serotonin Receptor,postsynaptic D2 receptor,Dopamine Receptor,5-HT2A,schizophrenia,ITI 007,Lumateperone,inhibit,Inhibitor,5-HT Receptor,5-hydroxytryptamine Receptor
  • Lumateperone ITI-722
  • Lumepperone
  • Lumateperone, 10 mM in DMSO
  • Lumiperidone
  • 1-(4-fluorophenyl)-4-((6br,10as)-3-methyl-2,3,6b,9,10,10a-hexahydro-1h-pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalin-8(7h)-yl)butan-1-one
  • 313368-91-1
  • C24H28FN3O
  • API