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Sappanone A

Product Name
Sappanone A
CAS No.
102067-84-5
Chemical Name
Sappanone A
Synonyms
Sappanone A;3-(3,4-Dihydroxybenzylidene)-7-hydroxychroman-4-one;(E)-7-hydroxy-3-[(3,4-dihydroxyphenyl)methylene]-chroman-4-one;3-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-
CBNumber
CB63037515
Molecular Formula
C16H12O5
Formula Weight
284.26
MOL File
102067-84-5.mol
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Sappanone A Property

Boiling point:
605.5±55.0 °C(Predicted)
Density 
1.521±0.06 g/cm3(Predicted)
solubility 
DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 0.25 mg/ml
form 
A solid
pka
7.20±0.20(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23205
Product name
Sappanone A
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
23205
Product name
Sappanone A
Purity
≥98%
Packaging
5mg
Price
$134
Updated
2024/03/01
Cayman Chemical
Product number
23205
Product name
Sappanone A
Purity
≥98%
Packaging
10mg
Price
$252
Updated
2024/03/01
Cayman Chemical
Product number
23205
Product name
Sappanone A
Purity
≥98%
Packaging
25mg
Price
$550
Updated
2024/03/01
Cayman Chemical
Product number
23205
Product name
SappanoneA
Purity
≥98%
Packaging
50mg
Price
$792
Updated
2021/12/16
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Sappanone A Chemical Properties,Usage,Production

Description

Sappanone A is a homoisoflavonoid with diverse biological activities that has been isolated from the aerial parts of C. pulcherrima, the heartwood of C. sappan, and the stems of H. campechianum. In vitro, sappanone A inhibits 76.2, 59.2, 37.4, and 35.4% of FGFR1, KDR, c-Met, and c-Kit kinase activity, respectively, when used at a concentration of 10 μM. It also inhibits influenza viral neuraminidase (NA) with IC50 values of 0.7, 1.1, and 1 μM for H1N1, H3N2, and H9N2 influenza viral NAs, respectively. Sappanone A has antibacterial activity against Gram-positive B. subtilis, B. sphaericus, and S. aureus as well as Gram-negative K. aerogenes and C. violaceum. It also inhibits the growth of A. niger and C. albicans fungi. Sapannone A inhibits LPS-induced inflammatory responses in vitro and in vivo, reducing nitric oxide (NO), interleukin-6 (IL-6), and prostaglandin E2 (PGE2; ) production in RAW264.7 cells as well as LPS-induced mortality in mice. It also attenuates airway inflammation and mucus hypersecretion via activation of the Nrf2 signaling pathway in a mouse model of ovalbumin-induced asthma.

Uses

Sappanone A is a natural product flavonoid with some antioxidant properties that can be isolated from C. sappan.

Biological Activity

Sappanone A is a homoisoflavanone which exhibits anti-inflammatory effects via modulation of Nrf2 and NF-κB. Sappanone can attenuate allergic airway inflammation in Ovalbumin-induced asthma.

Sappanone A Preparation Products And Raw materials

Raw materials

Preparation Products

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Sappanone A Suppliers

Chengdu Senior Pharma Technology Co.Ltd.
Tel
+86-0838-2319818 +86-15982001943
Email
seniorpharma@163.com
Country
China
ProdList
420
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7887
Advantage
56
Heliosense Biotechnologies,Inc
Tel
0592-5667290 18649641090
Fax
0592-5667261
Email
info@heliosense.com
Country
China
ProdList
98
Advantage
58
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7057
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
Shanghai ChengShao Biological Technology Co., Ltd.
Tel
021-61847300 13341622919
Fax
021-61847300
Email
shcss01@163.com
Country
China
ProdList
4808
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62

102067-84-5, Sappanone ARelated Search:


  • Sappanone A
  • 3-[(3,4-Dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-4H-1-benzopyran-4-one
  • (E)-7-hydroxy-3-[(3,4-dihydroxyphenyl)methylene]-chroman-4-one
  • 3-(3,4-Dihydroxybenzylidene)-7-hydroxychroman-4-one
  • 4H-1-Benzopyran-4-one, 3-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydro-7-hydroxy-
  • 102067-84-5