4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35

Product Name: 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35
CAS No.: 1235403-62-9
Chemical Name: 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35
Synonyms: CS-2129;PF5089771;PF 05089771;Nav1.7-IN-1;PF-05089771 free base;PF 05089771, 10 mM in DMSO;PF 05089771;PF-05089771;PF05089771;PF-05089771 free base (PF05089771 free base);Benzenesulfonamide, 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-;4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide
CBNumber: CB63038789
Molecular Formula: C18H12Cl2FN5O3S2
Formula Weight: 500.35
MOL File: 1235403-62-9.mol

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4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Property

Boiling point:: 699.5±65.0 °C(Predicted)
Density: 1.673±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
pka: 5.58±0.40(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 5931
Product name: PF05089771
Purity: ≥98%(HPLC)
Packaging: 10
Price: $173
Updated: 2021/12/16

Tocris

Product number: 5931
Product name: PF05089771
Purity: ≥98%(HPLC)
Packaging: 50
Price: $724
Updated: 2021/12/16

ChemScene

Product number: CS-4194
Product name: PF05089771
Purity: 99.32%
Packaging: 5mg
Price: $185
Updated: 2021/12/16

ChemScene

Product number: CS-4194
Product name: PF05089771
Purity: 99.32%
Packaging: 25mg
Price: $395
Updated: 2021/12/16

Apolloscientific

Product number: BISN0013
Product name: PF-05089771
Purity: 98%
Packaging: 5mg
Price: $508
Updated: 2021/12/16

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4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Chemical Properties,Usage,Production

Description

PF-05089771 (1235403-62-9) is a potent and selective inhibitor of the voltage gated sodium channel 1.7 (Nav1.7).1,3 It is a state-dependent inhibitor with IC50 = 11 nM for the half-inactivated channels and IC50 ~ 10 μM for resting channels.1 Equipotent for human, monkey, dog, and mouse channels but 15x less potent for rat channels. Interacts equally with fast and slow inactivated Nav1.7 channels.2

Uses

PF 05089771 is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor, with IC50 values of 11 nM, 12 nM, 13 nM, 171 nM and 8 nM for hNav1.7, cynNav1.7, dogNav1.7, ratNav1.7, and musNav1.7, respectively. PF 05089771 is under the study for pain and diabetic neuropathy[1][2].

IC 50

Nav1.7

References

[1] ARISTOS J ALEXANDROU. Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release.[J]. PLoS ONE, 2016, 11 1: e0152405. DOI:10.1371/journal.pone.0152405
[2] JONATHAN W THEILE M L C Matthew D Fuller. The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels.[J]. Molecular Pharmacology, 2016, 90 5: 540-548. DOI:10.1124/mol.116.105437
[3] NIGEL. A. SWAIN*. Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of NaV1.7[J]. Journal of Medicinal Chemistry, 2017, 60 16: 7029-7042. DOI:10.1021/acs.jmedchem.7b00598

4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Suppliers

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1235403-62-9, 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35Related Search:

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) Acalabrutinib Ibrutinib

4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35

Nav1.7-IN-1

PF 05089771

4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide

CS-2129

PF 05089771;PF-05089771;PF05089771

PF5089771

4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide

PF-05089771 free base

Benzenesulfonamide, 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-

Na+ channels,diabetic,inhibit,Inhibitor,neuropathy,Sodium Channel,Na channels,TTX-R,PF 05089771,pain,tetrodotoxin

PF 05089771, 10 mM in DMSO

PF-05089771 free base (PF05089771 free base)

1235403-62-9

1235401-62-9

C18H12Cl2FN5O3S2

API