ChemicalBook > CAS DataBase List > 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35

4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35

Product Name
4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35
CAS No.
1235403-62-9
Chemical Name
4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35
Synonyms
CS-2129;PF5089771;PF 05089771;Nav1.7-IN-1;PF-05089771 free base;PF 05089771;PF-05089771;PF05089771;Benzenesulfonamide, 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-;4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide;4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide;Na+ channels,diabetic,inhibit,Inhibitor,neuropathy,Sodium Channel,Na channels,TTX-R,PF 05089771,pain,tetrodotoxin
CBNumber
CB63038789
Molecular Formula
C18H12Cl2FN5O3S2
Formula Weight
500.35
MOL File
1235403-62-9.mol
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4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Property

Boiling point:
699.5±65.0 °C(Predicted)
Density 
1.673±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (>25 mg/ml)
form 
solid
pka
5.58±0.40(Predicted)
color 
White
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

HS Code 
2935909099
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5931
Product name
PF05089771
Purity
≥98%(HPLC)
Packaging
10
Price
$173
Updated
2021/12/16
Tocris
Product number
5931
Product name
PF05089771
Purity
≥98%(HPLC)
Packaging
50
Price
$724
Updated
2021/12/16
Apolloscientific
Product number
BISN0013
Product name
PF-05089771
Purity
98%
Packaging
10mg
Price
$740
Updated
2021/12/16
ChemScene
Product number
CS-4194
Product name
PF05089771
Purity
99.32%
Packaging
5mg
Price
$185
Updated
2021/12/16
ChemScene
Product number
CS-4194
Product name
PF05089771
Purity
99.32%
Packaging
25mg
Price
$395
Updated
2021/12/16
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4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Chemical Properties,Usage,Production

Description

PF-05089771 (1235403-62-9) is a potent and selective inhibitor of the voltage gated sodium channel 1.7 (Nav1.7).1,3? It is a state-dependent inhibitor with IC50 = 11 nM for the half-inactivated channels and IC50 ~ 10 μM for resting channels.1? Equipotent for human, monkey, dog, and mouse channels but 15x less potent for rat channels. Interacts equally with fast and slow inactivated Nav1.7 channels.2

References

Alexandrou et al. (2016), ?Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release; PLoS One, 11 e0152405 Theile et al. (2016), The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels; Mol. Pharmacol., 90 540 Swain et al. (2017), Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na(V)1.7; J. Med. Chem., 60 7029

4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Suppliers

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1235403-62-9, 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35Related Search:


  • 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35
  • Nav1.7-IN-1
  • PF 05089771
  • 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide
  • CS-2129
  • PF 05089771;PF-05089771;PF05089771
  • PF5089771
  • 4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide
  • PF-05089771 free base
  • Benzenesulfonamide, 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-
  • Na+ channels,diabetic,inhibit,Inhibitor,neuropathy,Sodium Channel,Na channels,TTX-R,PF 05089771,pain,tetrodotoxin
  • 1235403-62-9
  • 1235401-62-9
  • C18H12Cl2FN5O3S2
  • API