4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35

Product Name: 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35
CAS No.: 1235403-62-9
Chemical Name: 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35
Synonyms: CS-2129;PF5089771;PF 05089771;Nav1.7-IN-1;PF-05089771 free base;PF 05089771;PF-05089771;PF05089771;Benzenesulfonamide, 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-;4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide;4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide;Na+ channels,diabetic,inhibit,Inhibitor,neuropathy,Sodium Channel,Na channels,TTX-R,PF 05089771,pain,tetrodotoxin
CBNumber: CB63038789
Molecular Formula: C18H12Cl2FN5O3S2
Formula Weight: 500.35
MOL File: 1235403-62-9.mol

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4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Property

Boiling point:: 699.5±65.0 °C(Predicted)
Density: 1.673±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (>25 mg/ml)
form: solid
pka: 5.58±0.40(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

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Safety

HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5931
Product name: PF05089771
Purity: ≥98%(HPLC)
Packaging: 10
Price: $173
Updated: 2021/12/16

Tocris

Product number: 5931
Product name: PF05089771
Purity: ≥98%(HPLC)
Packaging: 50
Price: $724
Updated: 2021/12/16

Apolloscientific

Product number: BISN0013
Product name: PF-05089771
Purity: 98%
Packaging: 10mg
Price: $740
Updated: 2021/12/16

ChemScene

Product number: CS-4194
Product name: PF05089771
Purity: 99.32%
Packaging: 5mg
Price: $185
Updated: 2021/12/16

ChemScene

Product number: CS-4194
Product name: PF05089771
Purity: 99.32%
Packaging: 25mg
Price: $395
Updated: 2021/12/16

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4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Chemical Properties,Usage,Production

Description

PF-05089771 (1235403-62-9) is a potent and selective inhibitor of the voltage gated sodium channel 1.7 (Nav1.7).1,3? It is a state-dependent inhibitor with IC50 = 11 nM for the half-inactivated channels and IC50 ~ 10 μM for resting channels.1? Equipotent for human, monkey, dog, and mouse channels but 15x less potent for rat channels. Interacts equally with fast and slow inactivated Nav1.7 channels.2

References

Alexandrou et al. (2016), ?Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release; PLoS One, 11 e0152405 Theile et al. (2016), The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels; Mol. Pharmacol., 90 540 Swain et al. (2017), Discovery of Clinical Candidate 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide (PF-05089771): Design and Optimization of Diaryl Ether Aryl Sulfonamides as Selective Inhibitors of Na(V)1.7; J. Med. Chem., 60 7029

4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35 Suppliers

China 49 India 1 United States 5 Global 55

Musechem

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InvivoChem

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TargetMol Chemicals Inc.

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ProdList: 19973
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1235403-62-9, 4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35Related Search:

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea methanesulfonate (1:1) Acalabrutinib Ibrutinib

4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide Molecular Weight: 500.35

Nav1.7-IN-1

PF 05089771

4-(2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy)-5-chloro-2-fluoro-N-(thiazol-4-yl)benzenesulfonamide

CS-2129

PF 05089771;PF-05089771;PF05089771

PF5089771

4-[2-(5-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide

PF-05089771 free base

Benzenesulfonamide, 4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-

Na+ channels,diabetic,inhibit,Inhibitor,neuropathy,Sodium Channel,Na channels,TTX-R,PF 05089771,pain,tetrodotoxin

1235403-62-9

1235401-62-9

C18H12Cl2FN5O3S2

API