BETA-HYDROXYISOVALERYLSHIKONIN

Product Name: BETA-HYDROXYISOVALERYLSHIKONIN
CAS No.: 7415-78-3
Chemical Name: BETA-HYDROXYISOVALERYLSHIKONIN
Synonyms: β-HIVS;Alkannin Impurity 1;β-Hydroxyisovalerylshikonin;β-hydroxylsovalerylshikonin;β-Hydroxyisovalerylshikonin;β-hydroxylsovalerylshikonin;BETA-HYDROXYISOVALERYSHIKONIN;Beta-Hydroxylsovalerylshikonin;BETA-HYDROXYISOVALERYLSHIKONIN;5,8-Dihydroxy-2-[(R)-1-[(3-hydroxy-3-methylbutanoyl)oxy]-4-methyl-3-pentenyl]-1,4-naphthalenedione
CBNumber: CB6304047
Molecular Formula: C21H24O7
Formula Weight: 388.41
MOL File: 7415-78-3.mol

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BETA-HYDROXYISOVALERYLSHIKONIN Property

Melting point:: 90-92 °C
Boiling point:: 616.9±55.0 °C(Predicted)
Density: 1.312±0.06 g/cm3(Predicted)
storage temp.: 4°C, protect from light
solubility: Soluble in DMSO
pka: 7.08±0.20(Predicted)
form: Solid
color: Brown to black
LogP: 2.424 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0032419
Product name: β-Hydroxyisovalerylshikonin
Purity: 99.83%
Packaging: 1mg
Price: $171
Updated: 2021/12/16

ChemScene

Product number: CS-0032419
Product name: β-Hydroxyisovalerylshikonin
Purity: 99.83%
Packaging: 5mg
Price: $514
Updated: 2021/12/16

Arctom

Product number: CFN93028
Product name: Beta-Hydroxyisovalerylshikonin
Purity: ≥98%
Packaging: 10mg
Price: $318
Updated: 2021/12/16

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BETA-HYDROXYISOVALERYLSHIKONIN Chemical Properties,Usage,Production

Uses

Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermum erythrorhizon, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells[1].

References

[1] Hashimoto S, et al. Beta-hydroxyisovalerylshikonin is a novel and potent inhibitor of protein tyrosine kinases. Jpn J Cancer Res. 2002 Aug;93(8):944-51. DOI:10.1111/j.1349-7006.2002.tb01341.x

BETA-HYDROXYISOVALERYLSHIKONIN Preparation Products And Raw materials

Raw materials

Preparation Products

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BETA-HYDROXYISOVALERYLSHIKONIN Suppliers

China 57 Japan 2 United States 3 USA 1 Global 63

Chengdu Biopurify Phytochemicals Ltd.

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7415-78-3, BETA-HYDROXYISOVALERYLSHIKONINRelated Search:

ISOBUTYRYLSHIKONIN Alkannin (BETA,BETA-DIMETHYLACRYL)SHIKONIN 3-(Acetyloxy)-3-methylbutanoic acid (1S)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-pentenyl ester BETA, BETA-DIMETHYLACRYLALKANNIN Dihydroechinofuran PLUMBAGIN BETA-HYDROXYISOVALERYLSHIKONIN Shikalkin Geroquinol ACETYLSHIKONIN DEOXYSHIKONIN 5,8-Dihydroxy-1,4-naphthoquinone Shikonin ISOVALERYLSHIKONIN

BETA-HYDROXYISOVALERYLSHIKONIN

BETA-HYDROXYISOVALERYSHIKONIN

3-Hydroxy-3-methylbutanoic acid (R)-1-[(1,4-dioxo-5,8-dihydroxy-1,4-dihydronaphthalene)-2-yl]-4-methyl-3-pentenyl ester

5,8-Dihydroxy-2-[(R)-1-[(3-hydroxy-3-methylbutanoyl)oxy]-4-methyl-3-pentenyl]-1,4-naphthalenedione

β-HIVS

β-Hydroxyisovalerylshikonin

Beta-Hydroxylsovalerylshikonin

β-hydroxylsovalerylshikonin

Alkannin Impurity 1

Butanoic acid, 3-hydroxy-3-methyl-, (1R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxo-2-naphthalenyl)-4-methyl-3-penten-1-yl ester

inhibit,Inhibitor,ErbB-1,BetaHydroxyisovalerylshikonin,β-Hydroxyisovalerylshikonin,EGFR,Src,Beta Hydroxyisovalerylshikonin,Epidermal growth factor receptor,HER1

(R)-1-(5,8-Dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-en-1-yl 3-hydroxy-3-methylbutanoate

β-Hydroxyisovalerylshikonin

β-hydroxylsovalerylshikonin

7415-78-3