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(R)-1-benzyl-5-methyl-1,4-diazepane

Appearance
Product Name
(R)-1-benzyl-5-methyl-1,4-diazepane
CAS No.
1620097-06-4
Chemical Name
(R)-1-benzyl-5-methyl-1,4-diazepane
Synonyms
(R)-1-benzyl-5-methyl-1,4-diazepane;(5R)-1-benzyl-5-methyl-1,4-diazepane;Relebactam Impurity 4;Suvorexant Impurity 27;Suvorexant (MK-4305) intermediate;(R)-1-benzyl-5-methyl-1,4-diazepane(For export only);(5R)-Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine;(5S)-Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine;1H-1,4-Diazepine, hexahydro-5-methyl-1-(phenylmethyl)-, (5R)-;Suvorexant intermediate (5R)-Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine
CBNumber
CB63040519
Molecular Formula
C13H20N2
Formula Weight
204.31
MOL File
1620097-06-4.mol
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(R)-1-benzyl-5-methyl-1,4-diazepane Property

Boiling point:
296.1±28.0 °C(Predicted)
Density 
0.974±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
10.65±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
0340DJ
Product name
(R)-1-Benzyl-5-methyl-1,4-diazepane
Packaging
10g
Price
$456
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
APN0008416
Product name
1H-1,4-DIAZEPINE, HEXAHYDRO-5-METHYL-1-(PHENYLMETHYL)-, (5R)-
Purity
95.00%
Packaging
5MG
Price
$496.27
Updated
2021/12/16
AK Scientific
Product number
0340DJ
Product name
(R)-1-Benzyl-5-methyl-1,4-diazepane
Packaging
5g
Price
$304
Updated
2021/12/16
Chemenu
Product number
CM104875
Product name
(5R)-1-benzyl-5-methyl-1,4-diazepane
Purity
95+%
Packaging
10g
Price
$330
Updated
2021/12/16
Alichem
Product number
1620097064
Product name
(R)-1-Benzyl-5-methyl-1,4-diazepane
Packaging
5g
Price
$499.2
Updated
2021/12/16
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(R)-1-benzyl-5-methyl-1,4-diazepane Chemical Properties,Usage,Production

Appearance

White crystal

Uses

(5R)-1-Benzyl-5-methyl-1,4-diazepane is a synthetic substance with inhibitory activity on calcium channels. It has been shown to be useful for the treatment of epilepsy and other neurological disorders in animal models. 

Synthesis

The synthesis of (5R)-1-benzyl-5-methyl-1,4-diazepane was achieved by a two step process that involved the coupling of benzaldehyde and methyl vinyl ketone followed by the formation of an azide from methyl nitrite. This substance was purified using liquid chromatography and high performance liquid chromatography, which yielded a purity of 99%. A validation study confirmed that the impurities did not exceed 1% in concentration.

Preparation

(R)-4-benzyl-7-methyl-1,4-diazepan-2,5-dione(6 mmol)Was dissolved in 60 ml of dry THF, and 1.35 g of LiAlH4 (36 mmol) was added portionwise under ice-cooling, and stirred at 25℃ for 4 h.After cooling to -10 ℃, 1.5 ml of H20 was added and 1.5 ml of 15% NaOH, 4.5 ml of H20 and a portion of MgS04 were added, stirred for 1 h, suction filtered and dried to afford 1.2 g of an oil yield 97.56%。    

(R)-1-benzyl-5-methyl-1,4-diazepane Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-1-benzyl-5-methyl-1,4-diazepane Suppliers

China 53 India 3 United States 4 Global 60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
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United States
ProdList
63687
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Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
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Synthonix Inc
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United States
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6872
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Combi-Blocks Inc.
Tel
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Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
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View Lastest Price from (R)-1-benzyl-5-methyl-1,4-diazepane manufacturers

Jiangsu Guotai Guomian Trading Co. Ltd.
Product
(R)-1-benzyl-5-methyl-1,4-diazepane 1620097-06-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
In house standard
Supply Ability
1 ton
Release date
2023-02-06
Career Henan Chemical Co
Product
Suvorexantintermediate 1620097-06-4
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-09

1620097-06-4, (R)-1-benzyl-5-methyl-1,4-diazepaneRelated Search:

Suvorexant intermediate (R)-(7-Methyl-1,4-diazepan-1-yl)(5-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl)Methanone Suvorexant intermediate Suvorexant intermediate 1H-1,4-Diazepine-1-carboxylic acid, hexahydro-5-Methyl-, phenylMethyl ester, (5R)- 5-Methyl-2-(1H-1,2,3-triazol-1-yl)benzoic acid (R)-5-chloro-2-(5-Methyl-1,4-diazepan-1-yl)benzo[d]oxazole hydrochloride

  • (R)-1-benzyl-5-methyl-1,4-diazepane
  • (5R)-1-benzyl-5-methyl-1,4-diazepane
  • Suvorexant intermediate (5R)-Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine
  • Suvorexant (MK-4305) intermediate
  • (5R)-Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine
  • 1H-1,4-Diazepine, hexahydro-5-methyl-1-(phenylmethyl)-, (5R)-
  • (R)-1-benzyl-5-methyl-1,4-diazepane(For export only)
  • (5S)-Hexahydro-5-methyl-1-(phenylmethyl)-1H-1,4-diazepine
  • Relebactam Impurity 4
  • Suvorexant Impurity 27
  • 1620097-06-4