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ML352

Product Name
ML352
CAS No.
1649450-12-3
Chemical Name
ML352
Synonyms
ML352;CS-1661;VU-0476201;VU-0476201;CS-1661;ML-352;4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]-N-{[3-(propan-2-yl)-1,2-oxazol-5-yl]methyl}benzamide;N-((3-Isopropylisoxazol-5-yl)methyl)-4-methoxy-3-((1-methylpiperidin-4-yl)oxy)benzamide , ML352;Benzamide, 4-methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]-
CBNumber
CB63040791
Molecular Formula
C21H29N3O4
Formula Weight
387.47
MOL File
1649450-12-3.mol
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ML352 Property

Boiling point:
538.1±50.0 °C(Predicted)
Density 
1.145±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO
form 
Powder
pka
13.03±0.46(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21878
Product name
ML-352
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
21878
Product name
ML-352
Purity
≥98%
Packaging
5mg
Price
$98
Updated
2024/03/01
Cayman Chemical
Product number
21878
Product name
ML-352
Purity
≥98%
Packaging
10mg
Price
$178
Updated
2024/03/01
TRC
Product number
M425350
Product name
ML352
Packaging
50mg
Price
$340
Updated
2021/12/16
ApexBio Technology
Product number
B5897
Product name
ML352
Packaging
10mg
Price
$201
Updated
2021/12/16
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ML352 Chemical Properties,Usage,Production

Uses

ML352 is a novel, noncompetitive inhibitor of the presynaptic choline transporter (1).

Biological Activity

the neurotransmitter acetylcholine (ach) plays a critical role in autonomic function, motor control, attention, learning, and memory, and reward. the high-affinity choline transporter (cht) is the ratelimiting determinant of ach synthesis, yet the transporter remains a largely undeveloped target for the detection and manipulation of synaptic cholinergic signaling. ml352 is a novel, noncompetitive inhibitor of the presynaptic choline transporter.

in vitro

at concentrations fully antagonized cht in transfected cells and nerve terminal preparations, ml352 exhibited no inhibition of acetylcholinesterase or cholineacetyltransferase and also lacked activity at dopamine, serotonin, and norepinephrine transporters, as well as many receptors and ion channels. ml352 exhibited noncompetitive choline uptake inhibition in intact cells and reduced the apparent density of hemicholinium-3 binding sites in membrane assays, indicating allosteric transporter interactions [1].

in vivo

dmpk studies revealed a high intravenous plasma clearance, a combination of the oral bioavailability and total brain concentrations indicate ml352 to be a suitable probe for studies of altered in vivo ach signaling and behavioral effects in rodents [2].

References

[1] ennis ea, wright j, retzlaff cl, mcmanus ob, lin z, huang x, wu m, li m, daniels js, lindsley cw, hopkins cr, blakely rd. identification and characterization of ml352: a novel, noncompetitive inhibitor of the presynaptic choline transporter. acs chem neurosci. 2015 mar 18;6(3):417-27.
[2] elizabeth ennis miss, jane wright, james tarr, charles locuson, corey hopkins, j daniels, craig lindsley and randy blakely. a novel approach to cholinergic signaling modulation: development and characterization of ml352, a novel, noncompetitive inhibitor of the presynaptic choline transporter. the faseb journal vol. 29 no. 1 supplement 932.6

ML352 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML352 Suppliers

Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
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China
ProdList
4566
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
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58
Jinan Yaoyan Pharmaceutical Co., Ltd.
Tel
Fax
-
Email
jnyaoyan@163.com
Country
China
ProdList
3069
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58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3253
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
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58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
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Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
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58
Changzhou Xuanye Technology Co., Ltd
Tel
15195022192
Email
279776773@qq.com
Country
China
ProdList
2011
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58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58

1649450-12-3, ML352Related Search:


  • ML352
  • CS-1661
  • VU-0476201
  • VU-0476201;CS-1661;ML-352
  • Benzamide, 4-methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]-
  • 4-methoxy-3-[(1-methylpiperidin-4-yl)oxy]-N-{[3-(propan-2-yl)-1,2-oxazol-5-yl]methyl}benzamide
  • N-((3-Isopropylisoxazol-5-yl)methyl)-4-methoxy-3-((1-methylpiperidin-4-yl)oxy)benzamide , ML352
  • 1649450-12-3