ChemicalBook > CAS DataBase List > Centrinone

Centrinone

Product Name: Centrinone
CAS No.: 1798871-30-3
Chemical Name: Centrinone
Synonyms: LCR-263;Centrinone;Centrinone (LCR-263);Centrinone, 10 mM in DMSO;Centrinone (LCR-263) ，S7837;LCR 263,Polo-like Kinase (PLK),LCR263,Inhibitor,inhibit,Centrinone;2-((2-Fluoro-4-((2-fluoro-3-nitrobenzyl)sulfonyl)phenyl)thio)-5-methoxy-N-(5-methyl-1H-pyrazol;2-((2-Fluoro-4-((2-fluoro-3-nitrobenzyl)sulfonyl)phenyl)thio)-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-morpholinopyrimidin-4-amine;2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine;4-Pyrimidinamine, 2-[[2-fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-
CBNumber: CB63041394
Molecular Formula: C26H25F2N7O6S2
Formula Weight: 633.65
MOL File: 1798871-30-3.mol

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Centrinone Property

Melting point:: >187°C (dec.)
Boiling point:: 924.2±75.0 °C(Predicted)
Density: 1.59±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: Aqueous Base (Very Slightly), DMSO (Slightly)
form: Solid
pka: 13.65±0.10(Predicted)
color: Off-White to Pale Brown

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 5687
Product name: Centrinone
Purity: ≥98%(HPLC)
Packaging: 10
Price: $259
Updated: 2021/12/16

TRC

Product number: C256613
Product name: Centrinone
Packaging: 5mg
Price: $385
Updated: 2021/12/16

ChemScene

Product number: CS-4921
Product name: Centrinone
Purity: 98.57%
Packaging: 5mg
Price: $144
Updated: 2021/12/16

Crysdot

Product number: CD31002920
Product name: Centrinone
Purity: 98+%
Packaging: 5mg
Price: $101
Updated: 2021/12/16

Crysdot

Product number: CD31002920
Product name: Centrinone
Purity: 98+%
Packaging: 10mg
Price: $166
Updated: 2021/12/16

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Centrinone Chemical Properties,Usage,Production

Uses

Centrinone is a reversible inhibitor of Polo-like kinase 4 (Plk4), a serine-threonine protein kinase that initiates centriole assembly.

IC 50

PLK4: 0.16 nM (Ki); PLK4 (G95L): 68.57 nM (Ki); Aurora A: 171 nM (Ki); Aurora B: 436.76 nM (Ki)

storage

Store at -20°C

Centrinone Preparation Products And Raw materials

Raw materials

Preparation Products

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1798871-30-3, CentrinoneRelated Search:

Centrinone

2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-4-pyrimidinamine

2-((2-Fluoro-4-((2-fluoro-3-nitrobenzyl)sulfonyl)phenyl)thio)-5-methoxy-N-(5-methyl-1H-pyrazol

LCR-263

4-Pyrimidinamine, 2-[[2-fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(4-morpholinyl)-

Centrinone (LCR-263)

LCR 263,Polo-like Kinase (PLK),LCR263,Inhibitor,inhibit,Centrinone

2-((2-Fluoro-4-((2-fluoro-3-nitrobenzyl)sulfonyl)phenyl)thio)-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-morpholinopyrimidin-4-amine

Centrinone, 10 mM in DMSO

Centrinone (LCR-263) ，S7837

1798871-30-3

C26H25F2N7O6S2