2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
- Product Name
- 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
- CAS No.
- 1572936-83-4
- Chemical Name
- 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
- Synonyms
- Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel;2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid;2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid;Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-
- CBNumber
- CB63049204
- Molecular Formula
- C18H14N2O5
- Formula Weight
- 338.31
- MOL File
- 1572936-83-4.mol
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Property
- Boiling point:
- 553.1±50.0 °C(Predicted)
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble
- form
- A crystalline solid
- pka
- 2.26±0.22(Predicted)
N-Bromosuccinimide Price
- Product number
- 21917
- Product name
- MONNA
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21917
- Product name
- MONNA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 21917
- Product name
- MONNA
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $169
- Updated
- 2024/03/01
- Product number
- 21917
- Product name
- MONNA
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $381
- Updated
- 2024/03/01
- Product number
- M226500
- Product name
- 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoicAcid
- Packaging
- 5mg
- Price
- $85
- Updated
- 2021/12/16
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Chemical Properties,Usage,Production
Description
MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.
Uses
2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.
storage
Store at +4°C
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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