2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
- Product Name
- 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
- CAS No.
- 1572936-83-4
- Chemical Name
- 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
- Synonyms
- MONNA, 10 mM in DMSO;Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel;2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid;2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid;Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-
- CBNumber
- CB63049204
- Molecular Formula
- C18H14N2O5
- Formula Weight
- 338.31
- MOL File
- 1572936-83-4.mol
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Property
- Boiling point:
- 553.1±50.0 °C(Predicted)
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble
- form
- A crystalline solid
- pka
- 2.26±0.22(Predicted)
- color
- Brown to dark brown
N-Bromosuccinimide Price
- Product number
- 21917
- Product name
- MONNA
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2026/04/30
- Product number
- 21917
- Product name
- MONNA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $128
- Updated
- 2026/04/30
- Product number
- 21917
- Product name
- MONNA
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $186
- Updated
- 2026/04/30
- Product number
- 21917
- Product name
- MONNA
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $420
- Updated
- 2026/04/30
- Product number
- 21917
- Product name
- MONNA
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Chemical Properties,Usage,Production
Description
MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.
Uses
2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.
storage
Store at +4°C
References
[1] SOO-JIN OH. MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1.[J]. ACS Applied Electronic Materials, 2013: 726-735. DOI: 10.1124/mol.113.087502
[2] D M B BOEDTKJER. New selective inhibitors of calcium-activated chloride channels – T16Ainh-A01, CaCCinh-A01 and MONNA – what do they inhibit[J]. British Journal of Pharmacology, 2015, 172 16: 4158-4172. DOI: 10.1111/bph.13201
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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