ChemicalBook > CAS DataBase List > 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid

Product Name
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
CAS No.
1572936-83-4
Chemical Name
2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
Synonyms
Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel;2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid;2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid;Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-
CBNumber
CB63049204
Molecular Formula
C18H14N2O5
Formula Weight
338.31
MOL File
1572936-83-4.mol
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2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Property

Boiling point:
553.1±50.0 °C(Predicted)
Density 
1.421±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml; Ethanol: slightly soluble
form 
A crystalline solid
pka
2.26±0.22(Predicted)
color 
Brown to dark brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21917
Product name
MONNA
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21917
Product name
MONNA
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
21917
Product name
MONNA
Purity
≥98%
Packaging
10mg
Price
$169
Updated
2024/03/01
Cayman Chemical
Product number
21917
Product name
MONNA
Purity
≥98%
Packaging
25mg
Price
$381
Updated
2024/03/01
TRC
Product number
M226500
Product name
2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoicAcid
Packaging
5mg
Price
$85
Updated
2021/12/16
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2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Chemical Properties,Usage,Production

Description

MONNA is a selective inhibitor of anoctamin-1 (ANO1; IC50 = 0.08 μM in Xenopus oocytes), a calcium-activated chloride channel (CaCC). It is selective for ANO1 over the chloride channels bestrophin-1, chloride channel protein 2, and cystic fibrosis transmembrane conductance regulator up to 10 μM. MONNA (10 μM) induces full vasorelaxation of preconstricted mouse isolated mesenteric arteries in the presence or absence of chloride. It also hyperpolarizes isolated rat mesenteric arteries under resting conditions.

Uses

2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid selectively inhibits the calcium-activated chloride channel, anoctamin-1. 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitrobenzoic Acid has potential applications for developing treatments for hypertension, cystic fibrosis, bronchitis, asthma, and hyperalgesia.

storage

Store at +4°C

2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid Suppliers

China 28 United Kingdom 2 United States 5 USA 1 Global 36
ZHIWE CHEMTECH CO LTD
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021-20221225 13917446399
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QQ:115820162
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sales@zhiwe.net
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China
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Nanjing Chemlin Chemical Co., Ltd
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025-83697070
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+86-25-83453306
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info@chemlin.com.cn
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China
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AN PharmaTech Co Ltd
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86(21)68097365
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sales@anpharma.net
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Pharmacodia (Beijing) Co.,Ltd
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+86-400-851-9921
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+86-10-82826195
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sales@pharmacodia.com
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China
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Shanghai EFE Biological Technology Co., Ltd.
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021-65675885 18964387627
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021-65675885
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China
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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Lynnchem
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Novachemistry
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44-20819178-90 02081917890
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(0)2080432064
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United Kingdom
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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DC Chemicals
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China
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1572936-83-4, 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acidRelated Search:


  • 2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
  • 2-((4-methoxynaphthalen-2-yl)amino)-5-nitrobenzoic acid
  • Benzoic acid, 2-[(4-methoxy-2-naphthalenyl)amino]-5-nitro-
  • Cl-Channels,inhibit,MONNA,Inhibitor,Chloride Channel
  • 1572936-83-4