TD-4208
- Product Name
- TD-4208
- CAS No.
- 864750-70-9
- Chemical Name
- TD-4208
- Synonyms
- Revefenacin;TD-4208;1-(2-(4-((4-carbamoylpiperidin-1-yl)methyl)-N-methylbenzamido)ethyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate;CPDD1221;REVENACIN;Refenaxin;GSK1160724;Lefennaxin;Rafenexine;Raffinazine
- CBNumber
- CB63054398
- Molecular Formula
- C35H43N5O4
- Formula Weight
- 597.75
- MOL File
- 864750-70-9.mol
TD-4208 Property
- Boiling point:
- 777.5±60.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : ≥ 125 mg/mL (209.12 mM)
- form
- Solid
- pka
- 13.34±0.70(Predicted)
- color
- White to off-white
- InChIKey
- FYDWDCIFZSGNBU-UHFFFAOYSA-N
- SMILES
- C(OC1CCN(CCN(C(=O)C2=CC=C(CN3CCC(C(N)=O)CC3)C=C2)C)CC1)(=O)NC1=CC=CC=C1C1=CC=CC=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 464649
- Product name
- Revefenacin
- Packaging
- 1mg
- Price
- $425
- Updated
- 2021/12/16
- Product number
- INB0005717
- Product name
- TD-4208
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.2
- Updated
- 2021/12/16
- Product number
- CS-7743
- Product name
- Revefenacin
- Purity
- 99.78%
- Packaging
- 2mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-7743
- Product name
- Revefenacin
- Purity
- 99.78%
- Packaging
- 5mg
- Price
- $192
- Updated
- 2021/12/16
- Product number
- CS-7743
- Product name
- Revefenacin
- Purity
- 99.78%
- Packaging
- 10mg
- Price
- $312
- Updated
- 2021/12/16
TD-4208 Chemical Properties,Usage,Production
Description
Revefenacin is a synthetic anticholinergic that is prescribed for the treatment of chronic obstructive pulmonary disease (COPD).
Uses
Revefenacin is used to treat chronic obstructive pulmonary disease (COPD), a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both. It is an anticholinergic drug that helps the muscles around the airways in the lungs stay relaxed to prevent symptoms such as wheezing, coughing, chest tightness, and shortness of breath.
Application
Revefenacin is an FDA-approved anticholinergic drug, a new tertiary amine biphenylcarbamate agent that also belongs to the long-acting muscarinic antagonist (LABA) family. It has the effect of relaxing the muscles around the airways of the lungs to make breathing easier. The structurally unstable tertiary amide produces a "soft drug" site, allowing rapid systemic clearance and minimising systemically mediated adverse effects. It can be used to treat symptoms such as wheezing, shortness of breath, cough and chest tightness in patients with chronic obstructive pulmonary disease (COPD: a group of diseases affecting the lungs and airways, including chronic bronchitis and emphysema).
brand name
Yupelri
Mechanism of action
Revefenacin is a long-acting cholinergic antagonist (LAMA) with high lung specificity. It works by binding to M3 muscarinic receptors on bronchial smooth muscle, inhibiting tracheal constriction caused by the release of acetylcholine from parasympathetic nerve terminals. It is clinically used for maintenance therapy in patients with chronic obstructive pulmonary disease (COPD).
Side effects
Common adverse reactions in clinical trials (1%-10%) were headache, nasopharyngitis, upper respiratory tract infection, back pain, bronchitis, dizziness, and hypertension.
TD-4208 Preparation Products And Raw materials
Raw materials
Preparation Products
TD-4208 Suppliers
- Tel
- 0523-86818997 18652728585
- sales@allyrise.com
- Country
- China
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- 2974
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- 60
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- 18951933883
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- QQ:1665798899
- leo.feng@liftpharm.com
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- China
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- 308
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- 58
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- 0531-88798968 18615218958
- yin3684895@126.com
- Country
- China
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- 182
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- 58
- Tel
- 18980796919; 18980796919
- 236656639@qq.com
- Country
- China
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- 58
- Tel
- 15633056635
- 2880679888@qq.com
- Country
- China
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- 2529
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- 58
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- 022-60189726 18812034280
- Fax
- 86-22-60979672
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- China
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- 143
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- 61
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
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- 2922
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- 55
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- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4861
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- 58
- Tel
- 025-57798810 18652991625;
- Fax
- 025-57019371
- sales@sunlidabio.com
- Country
- China
- ProdList
- 3239
- Advantage
- 55
- Tel
- 021-021-33632979 15002134094
- Fax
- 021-33632979
- marketing@targetmol.com
- Country
- China
- ProdList
- 8000
- Advantage
- 58
View Lastest Price from TD-4208 manufacturers
- Product
- Revefenacin 864750-70-9
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-06-05
- Product
- Revefenacin 864750-70-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-16
- Product
- Revefenacin 864750-70-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2025-02-19