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MFCD00167693

Product Name
MFCD00167693
CAS No.
199735-88-1
Chemical Name
MFCD00167693
Synonyms
HY-107999;MFCD00167693;CADD522 ，S0790;CADD522, 10 mM in DMSO;3-(N-(3,4-DICHLOROPHENYL)CARBAMOYL)-5-NORBORNENE-2-CARBOXYLIC ACID;3-[(3,4-dichlorophenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid;3-{[(3,4-dichlorophenyl)amino]carbonyl}bicyclo[2.2.1]hept-5-ene-2-carboxylic acid;Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 3-[[(3,4-dichlorophenyl)amino]carbonyl]-;inhibit,MDA-231,Inhibitor,Reactive Oxygen Species,CADD 522,MCF7,MDA-468,breast cancer,CADD522,T47D-RUNX2,CADD-522
CBNumber
CB63058321
Molecular Formula
C15H13Cl2NO3
Formula Weight
326.17
MOL File
199735-88-1.mol
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MFCD00167693 Property

Boiling point:
569.1±50.0 °C(Predicted)
Density 
1.529±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO:157.5(Max Conc. mg/mL);482.87(Max Conc. mM)
Ethanol:65.0(Max Conc. mg/mL);199.28(Max Conc. mM)
form 
A solid
pka
4.19±0.40(Predicted)
color 
White to off-white
InChI
1S/C15H13Cl2NO3/c16-10-4-3-9(6-11(10)17)18-14(19)12-7-1-2-8(5-7)13(12)15(20)21/h1-4,6-8,12-13H,5H2,(H,18,19)(H,20,21)
InChIKey
YSDNWNOGHQYWPK-UHFFFAOYSA-N
SMILES
O=C(C1C2C=CC(C1C(NC3=CC=C(C(Cl)=C3)Cl)=O)C2)O
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S720224
Product name
3-(N-(3,4-DICHLOROPHENYL)CARBAMOYL)-5-NORBORNENE-2-CARBOXYLIC ACID
Purity
AldrichCPR
Packaging
50MG
Price
$113
Updated
2025/07/31
Matrix Scientific
Product number
159610
Product name
3-{[(3,4-Dichlorophenyl)amino]carbonyl}bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
Packaging
0.500g
Price
$120
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD136060
Product name
3-{[(3,4-Dichlorophenyl)amino]carbonyl}bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
Packaging
1g
Price
$128
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD136060
Product name
3-{[(3,4-Dichlorophenyl)amino]carbonyl}bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
Packaging
500mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
159610
Product name
3-{[(3,4-Dichlorophenyl)amino]carbonyl}bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
Packaging
1g
Price
$150
Updated
2021/12/16
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MFCD00167693 Chemical Properties,Usage,Production

Uses

CADD522 is a potent inhibitor of RUNX2(runt-related transcription factor-2)-DNA.

Biological Activity

CADD522 is a cell-permeable, bioavailable, non-toxic carbamoyl-bicycloheptene-carboxylate th at inhibits RUNX2-DNA binding, thereby increases RUNX2 stability, upregulates RUNX2 expression levels and downregulates RUNX2 responsive genes transcription. CADD522 inhibits mitochondrial oxidative phosphorylation by decreasing the mitochondrial oxygen consumption rate and ATP production in human breast cancer cells in a RUNX2-independent manner. CADD-522 suppresses in vivo tumor growth and metastasis, and appreciably prolongs the survival rates without the need for surgery or chemotherapy.

in vivo

CADD522 (1, 5 and 20 mg/kg; i.p.; twice a week for 45 days) delays the onset of the tumors and suppresses tumor growth in mice[1].
CADD522 (10 mg/kg; i.p.; twice a week for 11 days) suppresses tumor metastasis and inhibits expression of Ki-67 in mice[1].

Animal Model:Female mice (6-week-old; MMTV-PyMT transgenic model)[1].
Dosage:1, 5 and 20 mg/kg
Administration:Intraperitoneal injection; twice a week for 45 days.
Result:Delayed the onset of the tumors, delayed tumor development and reduced tumor burden in transgenic MMTV-PyMT mice.
Reduced the tumor weight in mice.
Animal Model:Female NOD scid gamma (NSG) mice and nude mice (TNBC-PDX Br-001 model)[1].
Dosage:10 mg/kg
Administration:Intraperitoneal injection; twice a week for 11 days.
Result:Significant decreased tumor volume and markedly inhibited expression of Ki-67.
Inhibited experimental metastasis of BC cells in vivo.(did not significantly decrease body weight or influence the general health of animals).

IC 50

RUNX2: 10 nM ()

MFCD00167693 Preparation Products And Raw materials

Raw materials

Preparation Products

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MFCD00167693 Suppliers

China 42 United Kingdom 1 United States 8 Global 51
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199735-88-1, MFCD00167693Related Search:

CHLOROPHENYLSILANE Dichloromethylphenylsilane Phenylsilane Benzeneruthenium(II) chloride dimer Phenyltrichlorosilane

  • MFCD00167693
  • 3-{[(3,4-dichlorophenyl)amino]carbonyl}bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
  • HY-107999
  • Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid, 3-[[(3,4-dichlorophenyl)amino]carbonyl]-
  • inhibit,MDA-231,Inhibitor,Reactive Oxygen Species,CADD 522,MCF7,MDA-468,breast cancer,CADD522,T47D-RUNX2,CADD-522
  • 3-[(3,4-dichlorophenyl)carbamoyl]bicyclo[2.2.1]hept-5-ene-2-carboxylic acid
  • CADD522, 10 mM in DMSO
  • 3-(N-(3,4-DICHLOROPHENYL)CARBAMOYL)-5-NORBORNENE-2-CARBOXYLIC ACID
  • CADD522 ，S0790
  • 199735-88-1