(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

Product Name: (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
CAS No.: 1082066-29-2
Chemical Name: (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Synonyms: 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan.;3-Fluoro-4-(hydroxymethyl)phenylboronic acid Pinacol Ester;2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol;(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol;Benzenemethanol, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB63062872
Molecular Formula: C13H18BFO3
Formula Weight: 252.09
MOL File: 1082066-29-2.mol

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(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: White to off-white Solid

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 4721AJ
Product name: (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Packaging: 1g
Price: $367
Updated: 2021/12/16

Apolloscientific

Product number: PC510176
Product name: 3-Fluoro-4-(hydroxymethyl)phenylboronic acid Pinacol Ester
Packaging: 1g
Price: $978
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6660-3-1G
Product name: 3-Fluoro-4-(hydroxymethyl)phenylboronic acid, pinacol ester
Packaging: 1g
Price: $1159
Updated: 2021/12/16

Alichem

Product number: 1082066292
Product name: (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Packaging: 1g
Price: $400
Updated: 2021/12/16

Acrotein

Product number: UT00392
Product name: (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol
Purity: 97%
Packaging: 5g
Price: $693.98
Updated: 2021/12/16

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(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Chemical Properties,Usage,Production

Synthesis

73183-34-3

188582-62-9

1082066-29-2

3.1.1. Preparation of (2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (934-2) To a stirred solution of 4-bromo-2-fluorobenzyl alcohol (500 mg, 2.44 mmol) in dioxane (5 mL) under nitrogen protection was sequentially added pinacol ester of biboronate (929 mg, 3.66 mmol), [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride dichloromethane complex (198 mg, 0.24 mmol) and potassium acetate (717 mg, 7.32 mmol). The reaction mixture was stirred at 90 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and extracted with ethyl acetate and water by partitioning. The organic layer was separated, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the resulting crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate, 0-20% gradient) to afford the title compound (2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol (934-2) (300 mg, 48% yield) as a yellow oil.

References

[1] Patent: US2018/194762, 2018, A1. Location in patent: Paragraph 0740-0741
[2] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 18, p. 4984 - 4995

(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Preparation Products And Raw materials

Raw materials

Preparation Products

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(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol Suppliers

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1082066-29-2, (2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanolRelated Search:

(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol

3-Fluoro-4-(hydroxymethyl)phenylboronic acid Pinacol Ester

2-fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

Benzenemethanol, 2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan.

1082066-29-2