AJMALICINE HYDROCHLORIDE
- Product Name
- AJMALICINE HYDROCHLORIDE
- CAS No.
- 4373-34-6
- Chemical Name
- AJMALICINE HYDROCHLORIDE
- Synonyms
- D-YOHIMBINE;AJMALICIN HCL;AJMALICINE HCL;Einecs 224-471-9;RAUBASINE HYDROCHLORIDE;AJMALICINE HYDROCHLORIDE;gamma-yohimbinhydrochloride;gamma-yohimbinehydrochloride;ajmalicine,monohydrochloride;DELTA-YOHIMBINE HYDROCHLORIDE
- CBNumber
- CB6309103
- Molecular Formula
- C21H25ClN2O3
- Formula Weight
- 388.89
- MOL File
- 4373-34-6.mol
AJMALICINE HYDROCHLORIDE Property
- Melting point:
- 275-300 °C
Safety
- Hazard Codes
- Xn
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- RTECS
- AX7890000
- F
- 10-23
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- HBL0000084
- Product name
- AJMALICINE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $713.1
- Updated
- 2021/12/16
AJMALICINE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Ajmalicine (Raubasine) hydrochloride is a potent adrenolytic agent which preferentially blocks α1-adrenoceptor. Ajmalicine hydrochloride is an reversible but non-competitive nicotine receptor full inhibitor, with an IC50 of 72.3 μM. Ajmalicine hydrochloride also can be used as anti-hypertensive, and serpentine, with sedative activity[1][2].
in vivo
Ajmalicine hydrochloride blocking the pressor action of electrical stimulation and is active against sympathetic stimulation[1].
Ajmalicine hydrochloride (0.5-4 mg/kg) induces a marked dose-dependent inhibition against the pressor response to noradrenaline[1].
| Animal Model: | Male Wistar rats (300-350 g)[1] |
| Dosage: | 0.5, 1, 2, and 4 mg/kg |
| Administration: | IV, once |
| Result: | Induced a marked dose-dependent inhibition against the pressor response to noradrenaline. |
IC 50
α1-adrenergic receptor; α2-adrenergic receptor
Purification Methods
This hydrochloride crystallises from MeOH or EtOH. Its solubility is 0.315g/100g of H2O at 100o. [Beilstein 27 III/IV 7928.]
References
[1] Roquebert J, et al. Inhibition of the alpha 1 and alpha 2-adrenoceptor-mediated pressor response in pithed rats by raubasine, tetrahydroalstonine and akuammigine. Eur J Pharmacol. 1984 Oct 30;106(1):203-5. DOI:10.1016/0014-2999(84)90698-8
[2] Pereira DM, et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine. 2010 Jul;17(8-9):646-52. DOI:10.1016/j.phymed.2009.10.008
[3] Demichel P, et al. Effects of raubasine stereoisomers on pre- and postsynaptic alpha-adrenoceptors in the rat vas deferens. Br J Pharmacol. 1984 Oct;83(2):505-10 DOI:10.1111/j.1476-5381.1984.tb16514.x
AJMALICINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from AJMALICINE HYDROCHLORIDE manufacturers
- Product
- AJMALICINE HYDROCHLORIDE 4373-34-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-27